Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation
Samelko, Lauryn, Landgraeber, Stefan, McAllister, Kyron, Jacobs, Joshua, Hallab, Nadim James
Published in PloS one (28.07.2016)
Published in PloS one (28.07.2016)
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Journal Article
Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms
Caicedo, Marco S., Samelko, Lauryn, McAllister, Kyron, Jacobs, Joshua J., Hallab, Nadim J.
Published in Journal of orthopaedic research (01.10.2013)
Published in Journal of orthopaedic research (01.10.2013)
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Journal Article
Do Battlefield Injury-acquired Indwelling Metal Fragments Induce Metal Immunogenicity?
Samelko, Lauryn, Petfield, Joseph, McAllister, Kyron, Hsu, Joseph, Hawkinson, Michael, Jacobs, Joshua J, Hallab, Nadim J
Published in Clinical orthopaedics and related research (01.04.2020)
Published in Clinical orthopaedics and related research (01.04.2020)
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Journal Article
Establishing clinically meaningful ranges of metal hypersensitivity in orthopaedic patients using COVID-19 vaccine-induced adaptive immune responses from fully vaccinated adults
Caicedo, Marco S., Flores, Vianey, Siapno, Rochelle, Crosby, Michael, Samelko, Lauryn A., Jacobs, Joshua J., Hallab, Nadim J.
Published in Journal of orthopaedics (01.02.2024)
Published in Journal of orthopaedics (01.02.2024)
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Journal Article
COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively
Caicedo, Marco S, Flores, Vianey, Padilla, Alicia, Lauryn, Samelko, Jacobs, Joshua J, Hallab, Nadim J
Published in Journal of orthopaedic surgery and research (30.06.2021)
Published in Journal of orthopaedic surgery and research (30.06.2021)
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Journal Article
The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants
Hallab, Nadim James, Samelko, Lauryn, Hammond, Dennis
Published in Aesthetic surgery journal (31.01.2019)
Published in Aesthetic surgery journal (31.01.2019)
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Journal Article
Particulate Debris Released From Breast Implant Surfaces Is Highly Dependent on Implant Type
Hallab, Nadim James, Samelko, Lauryn, Hammond, Dennis
Published in Aesthetic surgery journal (14.06.2021)
Published in Aesthetic surgery journal (14.06.2021)
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Journal Article
Translational characterization of macrophage responses to stable and non-stable CoCrMo wear and corrosion debris generated in-situ for total hip replacement
Ebinger, Kathrin, Samelko, Lauryn, Radice, Simona, Hallab, Nadim J., Wimmer, Markus A.
Published in Biotribology (Oxford) (01.12.2023)
Published in Biotribology (Oxford) (01.12.2023)
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Journal Article
TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles: PATHOGEN RECEPTOR DEPENDENT IMMUNE REACTIVITY TO IMPLANT PARTICLES
Samelko, Lauryn, Landgraeber, Stefan, McAllister, Kyron, Jacobs, Joshua, Hallab, Nadim J.
Published in Journal of orthopaedic research (01.05.2017)
Published in Journal of orthopaedic research (01.05.2017)
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Journal Article
Do Battlefield Injury-acquired Indwelling Metal Fragments Induce Metal Immunogenicity?
Samelko, Lauryn, Petfield, Joseph, McAllister, Kyron, Hsu, Joseph, Hawkinson, Michael, Jacobs, Joshua J, Hallab, Nadim J
Published in Clinical orthopaedics and related research (05.09.2019)
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Published in Clinical orthopaedics and related research (05.09.2019)
Journal Article
Cobalt-Alloy Implant Debris Induce HIF-1[alpha] Hypoxia Associated Responses: A Mechanism for Metal-Specific Orthopedic Implant Failure
Samelko, Lauryn, Caicedo, Marco S, Lim, Seung-Jae, Della-Valle, Craig, Jacobs, Joshua, Hallab, Nadim J
Published in PloS one (20.06.2013)
Published in PloS one (20.06.2013)
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Journal Article
CoCrMo alloy vs . UHMWPE Particulate Implant Debris Induces Sex Dependent Aseptic Osteolysis Responses In Vivo using a Murine Model
Landgraeber, Stefan, Samelko, Lauryn, McAllister, Kyron, Putz, Sebastian, Jacobs, Joshua J, Hallab, Nadim James
Published in The open orthopaedics journal (30.03.2018)
Published in The open orthopaedics journal (30.03.2018)
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Journal Article
Methotrexate mitgates UHMWPE-induced inflammatory osteolysis in murine calvaria model, more than anti-TNF or anti-IL-1R treatments: Implications for extending implant lifetimes
Lauryn, Samelko, Kyron, Mcallister, Joshua, Jacobs, Nadim, Hallab
Published in Frontiers in bioengineering and biotechnology (2016)
Published in Frontiers in bioengineering and biotechnology (2016)
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Journal Article
Implant debris particle size affects serum protein adsorption which may contribute to particle size-based bioreactivity differences
Reddy, Anand, Caicedo, Marco S, Samelko, Lauryn, Jacobs, Joshua J, Hallab, Nadim James
Published in Journal of long-term effects of medical implants (2014)
Published in Journal of long-term effects of medical implants (2014)
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Journal Article
Innate inflammatory cytokine response in periprosthetic tissue of failed metal-on-metal is significantly greater than failed metal-on-polyethylene THA implants
Lauryn, Samelko, Kyron, Mcallister, Robert, Urban, Deborah, Hall, Joshua, Jacobs, Nadim, Hallab
Published in Frontiers in bioengineering and biotechnology (2016)
Published in Frontiers in bioengineering and biotechnology (2016)
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Journal Article