The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production
Laughlin, Steven K., Clark, Michael P., Djung, Jane F., Golebiowski, Adam, Brugel, Todd A., Sabat, Mark, Bookland, Roger G., Laufersweiler, Matthew J., VanRens, John C., Townes, Jennifer A., De, Biswanath, Hsieh, Lily C., Xu, Susan C., Walter, Richard L., Mekel, Marlene J., Janusz, Michael J.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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Journal Article
Development of New Carboxylic Acid-Based MMP Inhibitors Derived from Functionalized Propargylglycines
Natchus, Michael G, Bookland, Roger G, Laufersweiler, Matthew J, Pikul, Staszek, Almstead, Neil G, De, Biswanath, Janusz, Michael J, Hsieh, Lily C, Gu, Fei, Pokross, Matthew E, Patel, Vikram S, Garver, Susan M, Peng, Sean X, Branch, Todd M, King, Selane L, Baker, Timothy R, Foltz, David J, Mieling, Glen E
Published in Journal of medicinal chemistry (29.03.2001)
Published in Journal of medicinal chemistry (29.03.2001)
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Journal Article
The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)
Sabat, Mark, VanRens, John C., Laufersweiler, Matthew J., Brugel, Todd A., Maier, Jennifer, Golebiowski, Adam, De, Biswanath, Easwaran, Vijayasurian, Hsieh, Lily C., Walter, Richard L., Mekel, Marlene J., Evdokimov, Artem, Janusz, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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Journal Article
Development of Orally Bioavailable Bicyclic Pyrazolones as Inhibitors of Tumor Necrosis Factor-α Production
Clark, Michael P, Laughlin, Steven K, Laufersweiler, Matthew J, Bookland, Roger G, Brugel, Todd A, Golebiowski, Adam, Sabat, Mark P, Townes, Jennifer A, VanRens, John C, Djung, Jane F, Natchus, Michael G, De, Biswanath, Hsieh, Lily C, Xu, Susan C, Walter, Rick L, Mekel, Marlene J, Heitmeyer, Sandra A, Brown, Kimberly K, Juergens, Karen, Taiwo, Yetunde O, Janusz, Michael J
Published in Journal of medicinal chemistry (20.05.2004)
Published in Journal of medicinal chemistry (20.05.2004)
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Journal Article
The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold
Tullis, Joshua S., Laufersweiler, Matthew J., VanRens, John C., Natchus, Michael G., Bookland, Roger G., Almstead, Neil G., Pikul, Stanislaw, De, Biswanath, Hsieh, Lily C., Janusz, Michael J., Branch, Todd M., Peng, Sean X., Jin, Yingkun Y., Hudlicky, Tomas, Oppong, Kofi
Published in Bioorganic & medicinal chemistry letters (06.08.2001)
Published in Bioorganic & medicinal chemistry letters (06.08.2001)
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Journal Article
Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3)
Clark, Michael P., George, Kelly M., Bookland, Roger G., Chen, Jack, Laughlin, Steven K., Thakur, Kumar D., Lee, Wenlin, Davis, Jan R., Cabrera, Ed J., Brugel, Todd A., VanRens, John C., Laufersweiler, Matthew J., Maier, Jennifer A., Sabat, Mark P., Golebiowski, Adam, Easwaran, Vijay, Webster, Mark E., De, Biswanath, Zhang, George
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Journal Article
Synthesis of novel pyrimido[4,5-c]pyridazines and 1,2-dihydro-3a,7,9,9b-tetraaza-cyclopenta[a]naphthalen-3-ones as potent inhibitors of lymphocyte specific kinase (lck)
VanRens, John C., Sabat, Mark, Brugel, Todd A., Maier, Jennifer, Laufersweiler, Matthew J., Golebiowski, Adam, Berberich, Steve, De, Biswanath
Published in Heterocycles (01.10.2006)
Published in Heterocycles (01.10.2006)
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Journal Article
The development of novel 1,2-dihydro-pyrimido[4,5- c]pyridazine based inhibitors of lymphocyte specific kinase (Lck)
Sabat, Mark, VanRens, John C., Brugel, Todd A., Maier, Jennifer, Laufersweiler, Matthew J., Golebiowski, Adam, De, Biswanath, Easwaran, Vijayasurian, Hsieh, Lily C., Rosegen, Jeff, Berberich, Steve, Suchanek, Eric, Janusz, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Journal Article
Development of N-4,6-pyrimidine- N-alkyl- N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase
Maier, Jennifer A., Brugel, Todd A., Sabat, Mark, Golebiowski, Adam, Laufersweiler, Matthew J., VanRens, John C., Hopkins, Corey R., De, Biswanath, Hsieh, Lily C., Brown, Kimberly K., Easwaran, Vijayasurian, Janusz, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Journal Article
Development of N-2,4-pyrimidine-N-phenyl-N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1
Brugel, Todd A., Maier, Jennifer A., Clark, Michael P., Sabat, Mark, Golebiowski, Adam, Bookland, Roger G., Laufersweiler, Matthew J., Laughlin, Steven K., VanRens, John C., De, Biswanath, Hsieh, Lily C., Mekel, Marlene J., Janusz, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production
Sabat, Mark, VanRens, John C., Clark, Michael P., Brugel, Todd A., Maier, Jennifer, Bookland, Roger G., Laufersweiler, Matthew J., Laughlin, Steven K., Golebiowski, Adam, De, Biswanath, Hsieh, Lily C., Walter, Richard L., Mekel, Marlene J., Janusz, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Journal Article
The development of monocyclic pyrazolone based cytokine synthesis inhibitors
Golebiowski, Adam, Townes, Jennifer A., Laufersweiler, Matthew J., Brugel, Todd A., Clark, Michael P., Clark, Cynthia M., Djung, Jane F., Laughlin, Steven K., Sabat, Mark P., Bookland, Roger G., VanRens, John C., De, Biswanath, Hsieh, Lily C., Janusz, Michael J., Walter, Richard L., Webster, Mark E., Mekel, Marlene J.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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Journal Article
Development of N-2,4-pyrimidine-N-phenyl-N′-alkyl ureas as orally active inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 2
Maier, Jennifer A., Brugel, Todd A., Clark, Michael P., Sabat, Mark, Golebiowski, Adam, Bookland, Roger G., Laufersweiler, Matthew J., Laughlin, Steven K., VanRens, John C., De, Biswanath, Hsieh, Lily C., Brown, Kimberly K., Juergens, Karen, Walter, Richard L., Janusz, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
The development of novel inhibitors of tumor necrosis factor-α (TNF-α) production based on substituted [5,5]-bicyclic pyrazolones
Laufersweiler, Matthew J, Brugel, Todd A, Clark, Michael P, Golebiowski, Adam, Bookland, Roger G, Laughlin, Steven K, Sabat, Mark P, Townes, Jennifer A, VanRens, John C, De, Biswanath, Hsieh, Lily C, Heitmeyer, Sandra A, Juergens, Karen, Brown, Kimberly K, Mekel, Marlene J, Walter, Richard L, Janusz, Michael J
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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Journal Article
The development of new bicyclic pyrazole-based cytokine synthesis inhibitors
Townes, Jennifer A., Golebiowski, Adam, Clark, Michael P., Laufersweiler, Matthew J., Brugel, Todd A., Sabat, Mark, Bookland, Roger G., Laughlin, Steve K., VanRens, John C., De, Biswanath, Hsieh, Lily C., Xu, Susan C., Janusz, Michael J., Walter, Richard L.
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
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Journal Article
Convergent synthesis of 2,3-bisarylpyrazolones through cyclization of bisacylated pyrazolidines and hydrazines
Brugel, Todd A., Hudlicky, Tomas, Clark, Michael P., Golebiowski, Adam, Sabat, Mark, Endoma, Mary Ann A., Bui, Vu, Adams, David, Laufersweiler, Matthew J., Maier, Jennifer A., Bookland, Roger G., De, Biswanath
Published in Tetrahedron letters (08.05.2006)
Published in Tetrahedron letters (08.05.2006)
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Journal Article
Corrigendum to “Development of N-2,4-pyrimidine- N-phenyl- N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1” [Bioorg. Med. Chem. Lett. 16 (2006) 3510–3513]
Brugel, Todd A., Maier, Jennifer A., Clark, Michael P., Sabat, Mark, Golebiowski, Adam, Bookland, Roger G., Laufersweiler, Matthew J., Laughlin, Steven K., VanRens, John C., De, Biswanath, Hsieh, Lily C., Mekel, Marlene J., Janusz, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Journal Article