Potential function for the Huntingtin protein as a scaffold for selective autophagy
Ochaba, Joseph, Lukacsovich, Tamás, Csikos, George, Zheng, Shuqiu, Margulis, Julia, Salazar, Lisa, Mao, Kai, Lau, Alice L., Yeung, Sylvia Y., Humbert, Sandrine, Saudou, Frédéric, Klionsky, Daniel J., Finkbeiner, Steven, Zeitlin, Scott O., Marsh, J. Lawrence, Housman, David E., Thompson, Leslie M., Steffan, Joan S.
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
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TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease
Zhao, Xiaobei, Chen, Xu-Qiao, Han, Eugene, Hu, Yue, Paik, Paul, Ding, Zhiyong, Overman, Julia, Lau, Alice L., Shahmoradian, Sarah H., Chiu, Wah, Thompson, Leslie M., Wu, Chengbiao, Mobley, William C.
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2016)
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Calcium Dynamics in Astrocytes During Cell Injury
Wakida, Nicole M., Gomez-Godinez, Veronica, Li, Huayan, Nguyen, Jessica, Kim, Edward K., Dynes, Joseph L., Othy, Shivashankar, Lau, Alice L., Ding, Peng, Shi, Linda, Carmona, Christopher, Thompson, Leslie M., Cahalan, Michael D., Berns, Michael W.
Published in Frontiers in bioengineering and biotechnology (27.08.2020)
Published in Frontiers in bioengineering and biotechnology (27.08.2020)
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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, Alice L, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Mónica, Díaz-Barriga, A Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Kedaigle, Amanda J, Gipson, Theresa A, Yildirim, Ferah, Ng, Christopher W, Milani, Pamela, Housman, David E, Fraenkel, Ernest, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N
Published in Nature neuroscience (01.05.2017)
Published in Nature neuroscience (01.05.2017)
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Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization
Sanchez, Isabella I, Nguyen, Thai B, England, Whitney E, Lim, Ryan G, Vu, Anthony Q, Miramontes, Ricardo, Byrne, Lauren M, Markmiller, Sebastian, Lau, Alice L, Orellana, Iliana, Curtis, Maurice A, Faull, Richard Lewis Maxwell, Yeo, Gene W, Fowler, Christie D, Reidling, Jack C, Wild, Edward J, Spitale, Robert C, Thompson, Leslie M
Published in The Journal of clinical investigation (15.06.2021)
Published in The Journal of clinical investigation (15.06.2021)
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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Thompson, Leslie Michels, Aiken, Charity T, Kaltenbach, Linda S, Agrawal, Namita, Illes, Katalin, Khoshnan, Ali, Martinez-Vincente, Marta, Arrasate, Montserrat, O'Rourke, Jacqueline Gire, Khashwji, Hasan, Lukacsovich, Tamas, Zhu, Ya-Zhen, Lau, Alice L, Massey, Ashish, Hayden, Michael R, Zeitlin, Scott O, Finkbeiner, Steven, Green, Kim N, LaFerla, Frank M, Bates, Gillian, Huang, Lan, Patterson, Paul H, Lo, Donald C, Cuervo, Ana Maria, Marsh, J. Lawrence, Steffan, Joan S
Published in The Journal of cell biology (28.12.2009)
Published in The Journal of cell biology (28.12.2009)
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Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins
Fote, Gianna M, Eapen, Vinay V, Lim, Ryan G, Yu, Clinton, Salazar, Lisa, McClure, Nicolette R, McKnight, Jharrayne, Nguyen, Thai B, Heath, Marie C, Lau, Alice L, Villamil, Mark A, Miramontes, Ricardo, Kratter, Ian H, Finkbeiner, Steven, Reidling, Jack C, Paulo, Joao A, Kaiser, Peter, Huang, Lan, Housman, David E, Thompson, Leslie M, Steffan, Joan S
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
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IKKβ slows Huntington’s disease progression in R6/1 mice
Ochaba, Joseph, Fote, Gianna, Kachemov, Marketta, Thein, Soe, Yeung, Sylvia Y., Lau, Alice L., Hernandez, Sarah, Lim, Ryan G., Casale, Malcolm, Neel, Michael J., Monuki, Edwin S., Reidling, Jack, Housman, David E., Thompson, Leslie M., Steffan, Joan S.
Published in Proceedings of the National Academy of Sciences - PNAS (28.05.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (28.05.2019)
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Journal Article
Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes
Wakida, Nicole M., Lau, Alice L., Nguyen, Jessica, Cruz, Gladys Mae S., Fote, Gianna M., Steffan, Joan S., Thompson, Leslie M., Berns, Michael W.
Published in Journal of Huntington's disease (01.01.2022)
Published in Journal of Huntington's disease (01.01.2022)
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Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models
Franich, Nicholas R., Basso, Manuela, André, Emily A., Ochaba, Joseph, Kumar, Amit, Thein, Soe, Fote, Gianna, Kachemov, Marketta, Lau, Alice L., Yeung, Sylvia Y., Osmand, Alexander, Zeitlin, Scott O., Ratan, Rajiv R., Thompson, Leslie M., Steffan, Joan S.
Published in Journal of Huntington's disease (01.01.2018)
Published in Journal of Huntington's disease (01.01.2018)
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Journal Article
Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization
Sanchez, Isabella I, Nguyen, Thai B, England, Whitney E, Lim, Ryan G, Vu, Anthony Q, Miramontes, Ricardo, Byrne, Lauren M, Markmiller, Sebastian, Lau, Alice L, Orellana, Iliana, Curtis, Maurice A, Faull, Richard Lewis Maxwell, Yeo, Gene W, Fowler, Christie D, Reidling, Jack C, Wild, Edward J, Spitale, Robert C, Thompson, Leslie M
Published in The Journal of clinical investigation (15.06.2021)
Published in The Journal of clinical investigation (15.06.2021)
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Selective radiolabeling of cell surface proteins to a high specific activity
Thompson, James A, Lau, Alice L, Cunningham, Dennis D
Published in Biochemistry (Easton) (10.02.1987)
Published in Biochemistry (Easton) (10.02.1987)
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Aberrant splicing in Huntington's disease via disrupted TDP-43 activity accompanied by altered m6A RNA modification
Nguyen, Thai B, Miramontes, Ricardo, Chillon-Marinas, Carlos, Maimon, Roy, Vazquez-Sanchez, Sonia, Lau, Alice L, McClure, Nicolette R, England, Whitney E, Singha, Monika, Stocksdale, Jennifer T, Jang, Ki-Hong, Jung, Sunhee, McKnight, Jharrayne I, Ho, Leanne N, Faull, Richard L M, Steffan, Joan S, Reidling, Jack C, Jang, Cholsoon, Lee, Gina, Cleveland, Don W, Lagier-Tourenne, Clotilde, Spitale, Robert C, Thompson, Leslie M
Published in bioRxiv : the preprint server for biology (02.11.2023)
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Published in bioRxiv : the preprint server for biology (02.11.2023)
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Protease Nexin-1, an Antithrombin with Neurite Outgrowth Activity, is Reduced in Alzheimer Disease
Wagner, Steven L., Geddes, James W., Cotman, Carl W., Lau, Alice L., Gurwitz, David, Isackson, Paul J., Cunningham, Dennis D.
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.1989)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.1989)
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Inhibitors of urokinase and thrombin in cultured neural cells
Wagner, S L, Lau, A L, Nguyen, A, Mimuro, J, Loskutoff, D J, Isackson, P J, Cunningham, D D
Published in Journal of neurochemistry (01.01.1991)
Published in Journal of neurochemistry (01.01.1991)
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