Abstract 593: DCC-3084, a brain penetrant RAF dimer inhibitor, broadly inhibits BRAF class I, II, and III alterations leading to growth inhibition of intracranially implanted tumors in preclinical models
Al-Ani, Gada, Bulfer, Stacie L., Zwicker, Jefferey D., Crawley, Chase K., Elliot, Kristin M., Javed, Salim, Groer, Qi, Hood, Molly M., Large, Joshua W., Luther, Kylie, Romero, Yeni K., Stanley, Forrest A., Tanner, Daniel C., Telikepalli, Hanumaiah, Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 1640: DP-9024, an investigational small molecule modulator of the Integrated Stress Response kinase PERK, causes B-cell cancer growth inhibition as single agent and in combination with standard-of-care agents
Al-Ani, Gada, Groer, Qi, Rudeen, Aaron J., Elliott, Kristin M., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 1639: DP-9149, an investigational small molecule modulator of the Integrated Stress Response kinase GCN2, pre-clinically causes solid tumor growth inhibition as a single agent and regression in combination with standard of care agents
Al-Ani, Gada, Groer, Qi, Elliott, Kristin M., Rudeen, Aaron J., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javid, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 4938: DP-9024, an investigational small molecule modulator of the integrated stress response kinase GCN2, synergizes with asparaginase therapy in leukemic tumors
Al-Ani, Gada, Elliott, Kristin M., Groer, Qi, Rudeen, Aaron J., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 1613: Dimerization-induced activation of the integrated stress response kinase PERK by an investigational small molecule modulator, DP-9024
Al-Ani, Gada, Rudeen, Aaron J., Groer, Qi, Elliott, Kristin M., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javid, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 4033: Pan-exon mutant KIT inhibitor DCC-3009 demonstrates tumor regressions in preclinical gastrointestinal stromal tumor models
Smith, Bryan D., Vogeti, Subha, Caldwell, Timothy M., Telikepalli, Hanumaiah, Ahn, Yu Mi, Al-Ani, Gada, Bulfer, Stacie L., Greenwood, Andrew, Heiniger, Cale L., Large, Joshua W., Leary, Cynthia B., Lu, Wei-Ping, Luther, Kylie, Patt, William C., Petty, Max D., Romero, Yeni K., Stanley, Forrest A., Stoltz, Kristen L., Tanner, Daniel C., Yang, Sihyung, Zhan, Yu, Bourdonnec, Bertrand Le, Flynn, Daniel L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 4045: DCC-3084, a RAF dimer inhibitor, broadly inhibits BRAF class I, II, III, BRAF fusions, and RAS-driven solid tumors leading to tumor regression in preclinical models
Bulfer, Stacie L., Bourdonnec, Bertrand Le, Zwicker, Jeffery D., Ahn, Yu Mi, Al-Ani, Gada, Al-Hashimi, Hikmat, Crawley, Chase, Elliott, Kristin M., Faisal, Saqib, Harned, Andrew M., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Kennedy, Michael, Large, Joshua W., Leary, Cynthia B., Lu, Wei-Ping, Luther, Kylie, Petty, Max D., Picard, Hunter R., Proto, Justin T., Romero, Yeni K., Stanley, Forrest A., Stoltz, Kristen L., Tanner, Daniel C., Telikepalli, Hanumaiah, Timson, Mary J., Vogeti, Lakshminarayana, Vogeti, Subha, Yang, Sihyung, Zhong, Lexy H., Smith, Bryan D., Flynn, Daniel L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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