Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
Bian, Zehua, Wang, Qiang, Zhou, Xinyu, Tan, Tao, Park, Ki Ho, Kramer, H Fritz, McDougal, Alan, Laping, Nicholas J, Kumar, Sanjay, Adesanya, T M Ayodele, Sermersheim, Matthew, Yi, Frank, Wang, Xinxin, Wu, Junwei, Gumpper, Kristyn, Jiang, Qiwei, He, Duofen, Lin, Pei-Hui, Li, Haichang, Guan, Fangxia, Zhou, Jingsong, Kohr, Mark J, Zeng, Chunyu, Zhu, Hua, Ma, Jianjie
Published in Nature communications (11.10.2019)
Published in Nature communications (11.10.2019)
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PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome
Grande, Valentina, Ornaghi, Francesca, Comerio, Liliana, Restelli, Elena, Masone, Antonio, Corbelli, Alessandro, Tolomeo, Daniele, Capone, Vanessa, Axten, Jeffrey M, Laping, Nicholas J, Fiordaliso, Fabio, Sallese, Michele, Chiesa, Roberto
Published in Human molecular genetics (15.07.2018)
Published in Human molecular genetics (15.07.2018)
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Journal Article
Development of a Small-Molecule Serum-and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic
SHERK, Andrea B, FRIGO, Daniel E, NORRIS, John D, MCDONNELL, Donald P, SCHNACKENBERG, Christine G, BRAY, Jeffrey D, LAPING, Nicholas J, TRIZNA, Walter, HAMMOND, Marlys, PATTERSON, Jaclyn R, THOMPSON, Scott K, KAZMIN, Dmitri
Published in Cancer research (Chicago, Ill.) (15.09.2008)
Published in Cancer research (Chicago, Ill.) (15.09.2008)
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Journal Article
AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome
Lashinger, Erin S R, Steiginga, Matthew S, Hieble, J Paul, Leon, Lisa A, Gardner, Scott D, Nagilla, Rakesh, Davenport, Elizabeth A, Hoffman, Bryan E, Laping, Nicholas J, Su, Xin
Published in American journal of physiology. Renal physiology (01.09.2008)
Published in American journal of physiology. Renal physiology (01.09.2008)
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Journal Article
Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy
Koren, Shon A, Hamm, Matthew J, Cloyd, Ryan, Fontaine, Sarah N, Chishti, Emad, Lanzillotta, Chiara, Rodriguez-Rivera, Jennifer, Ingram, Alexandria, Bell, Michelle, Galvis-Escobar, Sara M, Zulia, Nicholas, Di Domenico, Fabio, Duong, Duc, Seyfried, Nicholas T, Powell, David, Vandsburger, Moriel, Frolinger, Tal, Hartz, Anika M S, Koren, 3rd, John, Axten, Jeffrey M, Laping, Nicholas J, Abisambra, Jose F
Published in International journal of molecular sciences (26.01.2021)
Published in International journal of molecular sciences (26.01.2021)
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Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria
Wang, Amy, Ziyadeh, Fuad N, Lee, Eun Young, Pyagay, Petr E, Sung, Sun Hee, Sheardown, Steven A, Laping, Nicholas J, Chen, Sheldon
Published in American journal of physiology. Renal physiology (01.11.2007)
Published in American journal of physiology. Renal physiology (01.11.2007)
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Journal Article
A Structural and in Vitro Characterization of Asoprisnil: A Selective Progesterone Receptor Modulator
Madauss, Kevin P, Grygielko, Eugene T, Deng, Su-Jun, Sulpizio, Anthony C, Stanley, Thomas B, Wu, Charlene, Short, Steve A, Thompson, Scott K, Stewart, Eugene L, Laping, Nicholas J, Williams, Shawn P, Bray, Jeffrey D
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2007)
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2007)
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Journal Article
Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis
Grygielko, Eugene T, Martin, William M, Tweed, Christopher, Thornton, Peter, Harling, John, Brooks, David P, Laping, Nicholas J
Published in The Journal of pharmacology and experimental therapeutics (01.06.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2005)
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Journal Article
Tgf-β3-induced palatal fusion is mediated by Alk-5/Smad pathway
Dudas, Marek, Nagy, Andre, Laping, Nicholas J, Moustakas, Aristidis, Kaartinen, Vesa
Published in Developmental biology (01.02.2004)
Published in Developmental biology (01.02.2004)
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Journal Article
Tumor-Specific Efficacy of Transforming Growth Factor-βRI Inhibition in Eker Rats
LAPING, Nicholas J, EVERITT, Jeffrey I, FRAZIER, Kendall S, BURGERT, Mark, PORTIS, Melisa J, CADACIO, Caprice, GOLD, Leslie I, WALKER, Cheryl L
Published in Clinical cancer research (15.05.2007)
Published in Clinical cancer research (15.05.2007)
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Journal Article
Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)
Callahan, James F, Burgess, Joelle L, Fornwald, James A, Gaster, Laramie M, Harling, John D, Harrington, Frank P, Heer, Jag, Kwon, Chet, Lehr, Ruth, Mathur, A, Olson, Barbara A, Weinstock, Joseph, Laping, Nicholas J
Published in Journal of medicinal chemistry (28.02.2002)
Published in Journal of medicinal chemistry (28.02.2002)
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Journal Article
SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motility
Hjelmeland, Mark D, Hjelmeland, Anita B, Sathornsumetee, Sith, Reese, Elizabeth D, Herbstreith, Michael H, Laping, Nicholas J, Friedman, Henry S, Bigner, Darell D, Wang, Xiao-Fan, Rich, Jeremy N
Published in Molecular cancer therapeutics (01.06.2004)
Published in Molecular cancer therapeutics (01.06.2004)
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Journal Article
Enhanced bladder capacity and reduced prostaglandin E2-mediated bladder hyperactivity in EP3 receptor knockout mice
McCafferty, Gerald P, Misajet, Blake A, Laping, Nicholas J, Edwards, Richard M, Thorneloe, Kevin S
Published in American journal of physiology. Renal physiology (01.08.2008)
Published in American journal of physiology. Renal physiology (01.08.2008)
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Journal Article
Effects of the beta 3-adrenergic receptor agonist disodium 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL-316243) on bladder micturition reflex in spontaneously hypertensive rats
Leon, Lisa A, Hoffman, Bryan E, Gardner, Scott D, Laping, Nicholas J, Evans, Christopher, Lashinger, Erin S R, Su, Xin
Published in The Journal of pharmacology and experimental therapeutics (01.07.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2008)
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Journal Article
Effects of Rho-kinase inhibition on myosin light chain phosphorylation and obstruction-induced detrusor overactivity
Marx, James O, Basha, Maureen E, Mohanan, Sunish, Hypolite, Joseph A, Chang, Shaohua, Wein, Alan J, Zderic, Stephen A, Laping, Nicholas J, Chacko, Samuel
Published in International journal of urology (01.03.2014)
Published in International journal of urology (01.03.2014)
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Journal Article
Discovery of 4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): A Potent, Selective, and Orally Active Transforming Growth Factor-β Type I Receptor Inhibitor
Gellibert, Françoise, de Gouville, Anne-Charlotte, Woolven, James, Mathews, Neil, Nguyen, Van-Loc, Bertho-Ruault, Cécile, Patikis, Angela, Grygielko, Eugene T, Laping, Nicholas J, Huet, Stéphane
Published in Journal of medicinal chemistry (06.04.2006)
Published in Journal of medicinal chemistry (06.04.2006)
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Journal Article
Estrogen-induced stromal cell-derived factor-1 (SDF-1/ Cxcl12) expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor α in rat uterine cells and tissues
Glace, Lindsay, Grygielko, Eugene T., Boyle, Ryan, Wang, Qi, Laping, Nicholas J., Sulpizio, Anthony C., Bray, Jeffrey D.
Published in Steroids (01.11.2009)
Published in Steroids (01.11.2009)
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Journal Article
Modulation of bladder function by prostaglandin EP3 receptors in the central nervous system
Su, Xin, Leon, Lisa A, Wu, Charlene W, Morrow, Dwight M, Jaworski, Jon-Paul, Hieble, J Paul, Lashinger, Erin S R, Jin, Jian, Edwards, Richard M, Laping, Nicholas J
Published in American journal of physiology. Renal physiology (01.10.2008)
Published in American journal of physiology. Renal physiology (01.10.2008)
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