Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities
Lapek, John D, Greninger, Patricia, Morris, Robert, Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Benes, Cyril H, Haas, Wilhelm
Published in Nature biotechnology (01.10.2017)
Published in Nature biotechnology (01.10.2017)
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Journal Article
Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer
Singh, Vishal, Yeoh, Beng San, Chassaing, Benoit, Xiao, Xia, Saha, Piu, Aguilera Olvera, Rodrigo, Lapek, John D., Zhang, Limin, Wang, Wei-Bei, Hao, Sijie, Flythe, Michael D., Gonzalez, David J., Cani, Patrice D., Conejo-Garcia, Jose R., Xiong, Na, Kennett, Mary J., Joe, Bina, Patterson, Andrew D., Gewirtz, Andrew T., Vijay-Kumar, Matam
Published in Cell (18.10.2018)
Published in Cell (18.10.2018)
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Journal Article
Reversible lysine-targeted probes reveal residence time-based kinase selectivity
Yang, Tangpo, Cuesta, Adolfo, Wan, Xiaobo, Craven, Gregory B., Hirakawa, Brad, Khamphavong, Penney, May, Jeffrey R., Kath, John C., Lapek, John D., Niessen, Sherry, Burlingame, Alma L., Carelli, Jordan D., Taunton, Jack
Published in Nature chemical biology (01.09.2022)
Published in Nature chemical biology (01.09.2022)
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Journal Article
Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
Askarian, Fatemeh, Lapek, Jr, John D, Dongre, Mitesh, Tsai, Chih-Ming, Kumaraswamy, Monika, Kousha, Armin, Valderrama, J Andrés, Ludviksen, Judith A, Cavanagh, Jorunn P, Uchiyama, Satoshi, Mollnes, Tom E, Gonzalez, David J, Wai, Sun N, Nizet, Victor, Johannessen, Mona
Published in Frontiers in microbiology (20.02.2018)
Published in Frontiers in microbiology (20.02.2018)
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Journal Article
Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr
Lapek, John D., Lewinski, Mary K., Wozniak, Jacob M., Guatelli, John, Gonzalez, David J.
Published in Molecular & cellular proteomics (01.08.2017)
Published in Molecular & cellular proteomics (01.08.2017)
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Journal Article
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation
Nicolay, Brandon N, Danielian, Paul S, Kottakis, Filippos, Lapek, Jr, John D, Sanidas, Ioannis, Miles, Wayne O, Dehnad, Mantre, Tschöp, Katrin, Gierut, Jessica J, Manning, Amity L, Morris, Robert, Haigis, Kevin, Bardeesy, Nabeel, Lees, Jacqueline A, Haas, Wilhelm, Dyson, Nicholas J
Published in Genes & development (01.09.2015)
Published in Genes & development (01.09.2015)
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Journal Article
Biomimetic Virulomics for Capture and Identification of Cell-Type Specific Effector Proteins
Lapek, John D, Fang, Ronnie H, Wei, Xiaoli, Li, Pengyang, Wang, Bo, Zhang, Liangfang, Gonzalez, David J
Published in ACS nano (26.12.2017)
Published in ACS nano (26.12.2017)
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Journal Article
Essential metabolism for a minimal cell
Breuer, Marian, Earnest, Tyler M, Merryman, Chuck, Wise, Kim S, Sun, Lijie, Lynott, Michaela R, Hutchison, Clyde A, Smith, Hamilton O, Lapek, John D, Gonzalez, David J, de Crécy-Lagard, Valérie, Haas, Drago, Hanson, Andrew D, Labhsetwar, Piyush, Glass, John I, Luthey-Schulten, Zaida
Published in eLife (18.01.2019)
Published in eLife (18.01.2019)
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Journal Article
Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance
Formentini, Laura, Ryan, Alexander J., Gálvez-Santisteban, Manuel, Carter, Leslie, Taub, Pam, Lapek, John D., Gonzalez, David J., Villarreal, Francisco, Ciaraldi, Theodore P., Cuezva, José M., Henry, Robert R.
Published in Diabetologia (01.10.2017)
Published in Diabetologia (01.10.2017)
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Journal Article
Group B Streptococcus Biofilm Regulatory Protein A Contributes to Bacterial Physiology and Innate Immune Resistance
Patras, Kathryn A, Derieux, Jaclyn, Al-Bassam, Mahmoud M, Adiletta, Nichole, Vrbanac, Alison, Lapek, John D, Zengler, Karsten, Gonzalez, David J, Nizet, Victor
Published in The Journal of infectious diseases (05.10.2018)
Published in The Journal of infectious diseases (05.10.2018)
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Journal Article
Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry
Lapek, John D., Jiang, Zhenze, Wozniak, Jacob M., Arutyunova, Elena, Wang, Steven C, Lemieux, M. Joanne, Gonzalez, David J., O'Donoghue, Anthony J.
Published in Molecular & cellular proteomics (01.05.2019)
Published in Molecular & cellular proteomics (01.05.2019)
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Journal Article
Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes
Sundar, Isaac K, Chung, Sangwoon, Hwang, Jae-Woong, Lapek, Jr, John D, Bulger, Michael, Friedman, Alan E, Yao, Hongwei, Davie, James R, Rahman, Irfan
Published in PloS one (01.02.2012)
Published in PloS one (01.02.2012)
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Journal Article
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function
Lin, Ying, Wozniak, Jacob M., Grimsey, Neil J., Girada, Sravan, Patwardhan, Anand, Molinar-Inglis, Olivia, Smith, Thomas H., Lapek, John D., Gonzalez, David J., Trejo, JoAnn
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2020)
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Journal Article
Phosphoproteomic analysis of thrombin- and p38 MAPK-regulated signaling networks in endothelial cells
Molinar-Inglis, Olivia, Wozniak, Jacob M., Grimsey, Neil J., Orduña-Castillo, Lennis B., Cheng, Norton, Lin, Ying, Gonzalez Ramirez, Monica L., Birch, Cierra A., Lapek, John D., Gonzalez, David J., Trejo, JoAnn
Published in The Journal of biological chemistry (01.04.2022)
Published in The Journal of biological chemistry (01.04.2022)
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Journal Article
Functional analysis of NsrR, a nitric oxide‐sensing Rrf2 repressor in Neisseria gonorrhoeae
Isabella, Vincent M., Lapek Jr, John D., Kennedy, Edward M., Clark, Virginia L.
Published in Molecular microbiology (01.01.2009)
Published in Molecular microbiology (01.01.2009)
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Journal Article
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling
Grimsey, Neil J., Narala, Rachan, Rada, Cara C., Mehta, Sohum, Stephens, Bryan S., Kufareva, Irina, Lapek, John, Gonzalez, David J., Handel, Tracy M., Zhang, Jin, Trejo, JoAnn
Published in Cell reports (Cambridge) (18.09.2018)
Published in Cell reports (Cambridge) (18.09.2018)
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Journal Article
PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib
Ding, Xia, Zhu, Zhou, Lapek, John, McMillan, Elizabeth A., Zhang, Alexander, Chung, Chi-Yeh, Dubbury, Sara, Lapira, Jennifer, Firdaus, Sarah, Kang, Xiaolin, Gao, Jingjin, Oyer, Jon, Chionis, John, Rollins, Robert A., Li, Lianjie, Niessen, Sherry, Bagrodia, Shubha, Zhang, Lianglin, VanArsdale, Todd
Published in Scientific reports (21.07.2022)
Published in Scientific reports (21.07.2022)
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Journal Article
Reversible lysine-targeted probes reveal residence time-based kinase selectivity
Yang, Tangpo, Cuesta, Adolfo, Wan, Xiaobo, Craven, Gregory B., Hirakawa, Brad, Khamphavong, Penney, May, Jeffrey R., Kath, John C., Lapek, John D., Niessen, Sherry, Burlingame, Alma L., Carelli, Jordan D., Taunton, Jack
Published in Nature chemical biology (01.09.2022)
Published in Nature chemical biology (01.09.2022)
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