Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration
Tang, Seng Chuan, Lagas, Jurjen S., Lankheet, Nienke A.G., Poller, Birk, Hillebrand, Michel J., Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.
Published in International journal of cancer (01.01.2012)
Published in International journal of cancer (01.01.2012)
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Journal Article
Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care
Lankheet, Nienke A G, Knapen, Lotte M, Schellens, Jan H M, Beijnen, Jos H, Steeghs, Neeltje, Huitema, Alwin D R
Published in Therapeutic drug monitoring (01.06.2014)
Published in Therapeutic drug monitoring (01.06.2014)
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Journal Article
The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand–foot syndrome
Lankheet, Nienke A. G., Huitema, Alwin D. R., Mallo, Henk, Adriaansz, Sandra, Haanen, John B. A. G., Schellens, Jan H. M., Beijnen, Jos H., Blank, Christian U.
Published in European journal of clinical pharmacology (01.12.2013)
Published in European journal of clinical pharmacology (01.12.2013)
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Journal Article
Quantification of sunitinib and N-desethyl sunitinib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry: validation and application in routine therapeutic drug monitoring
Lankheet, Nienke A G, Steeghs, N, Rosing, H, Schellens, J H M, Beijnen, J H, Huitema, A D R
Published in Therapeutic drug monitoring (01.04.2013)
Published in Therapeutic drug monitoring (01.04.2013)
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Journal Article
Erlotinib and pantoprazole: a relevant interaction or not?
Ter Heine, Rob, Fanggiday, James C., Lankheet, Nienke A. G., Beijnen, Jos H., Van Der Westerlaken, Monique M. L., Staaks, Gerald H. A., Malingré, Mirte M.
Published in British journal of clinical pharmacology (01.12.2010)
Published in British journal of clinical pharmacology (01.12.2010)
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Journal Article
Determination of Sunitinib and Its Active Metabolite N-Desethylsunitinib in Sweat of a Patient
Lankheet, Nienke A.G., Blank, Christian U., Mallo, Henk, Adriaansz, Sandra, Rosing, Hilde, Schellens, Jan H.M., Huitema, Alwin D.R., Beijnen, Jos H.
Published in Journal of analytical toxicology (01.10.2011)
Published in Journal of analytical toxicology (01.10.2011)
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Journal Article
Dose recommendations for anticancer drugs in patients with renal or hepatic impairment
Krens, Stefanie D, Lassche, Gerben, Jansman, Frank G A, Desar, Ingrid M E, Lankheet, Nienke A G, Burger, David M, van Herpen, Carla M L, van Erp, Nielka P
Published in The lancet oncology (01.04.2019)
Published in The lancet oncology (01.04.2019)
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Journal Article
The QT interval prolongation potential of anticancer and supportive drugs: a comprehensive overview
Giraud, Eline L, Ferrier, Kaylee R M, Lankheet, Nienke A G, Desar, Ingrid M E, Steeghs, Neeltje, Beukema, Rypko J, van Erp, Nielka P, Smolders, Elise J
Published in The lancet oncology (01.09.2022)
Published in The lancet oncology (01.09.2022)
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Relatively mild symptoms after chronic overdose with a double-dose encorafenib: a case report
Mian, Paola, Meussen, Elvera, Piersma, Djura, Lankheet, Nienke A G
Published in Anti-cancer drugs (01.06.2021)
Published in Anti-cancer drugs (01.06.2021)
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Optimizing the dose in cancer patients treated with imatinib, sunitinib and pazopanib
Lankheet, Nienke A. G., Desar, Ingrid M. E., Mulder, Sasja F., Burger, David M., Kweekel, Dinemarie M., Herpen, Carla M. L., Graaf, Winette T. A., Erp, Nielka P.
Published in British journal of clinical pharmacology (01.10.2017)
Published in British journal of clinical pharmacology (01.10.2017)
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Journal Article
P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib
Tang, Seng Chuan, Lankheet, Nienke A G, Poller, Birk, Wagenaar, Els, Beijnen, Jos H, Schinkel, Alfred H
Published in The Journal of pharmacology and experimental therapeutics (01.04.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2012)
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Journal Article
Relatively mild symptoms after an olanzapine intoxication in a 2-year-old girl with excessively high serum levels
Lankheet, Nienke A G, Padberg, Roos D, de Kluiver, Evelyne M, Wilhelm, Abraham J, van Woensel, Job B M, Beijnen, Jos H, Huitema, Alwin D R
Published in Journal of child and adolescent psychopharmacology (01.02.2011)
Published in Journal of child and adolescent psychopharmacology (01.02.2011)
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Journal Article
Concentrations of Erlotinib in Tumor Tissue and Plasma in Non–Small-Cell Lung Cancer Patients After Neoadjuvant Therapy
Lankheet, Nienke A.G, Schaake, Eva E, Burgers, Sjaak A, van Pel, Renée, Beijnen, Jos H, Huitema, Alwin D.R, Klomp, Houke
Published in Clinical lung cancer (01.07.2015)
Published in Clinical lung cancer (01.07.2015)
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Phase 1 Study of Combination Treatment with PTK 787/ZK 222584 and Cetuximab for Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics Analysis
Langenberg, Marlies H.G., Witteveen, Petronella O., Lankheet, Nienke A.G., Roodhart, Jeanine M.L., Rosing, Hilde, van den Heuvel, Ingeborg J.G.M., Beijnen, Jos H., Voest, Emile E.
Published in Neoplasia (New York, N.Y.) (01.02.2010)
Published in Neoplasia (New York, N.Y.) (01.02.2010)
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Journal Article
Use of the Child-Pugh score in anticancer drug dosing decision making: proceed with caution – Authors' reply
Krens, Stefanie D, Lassche, Gerben, Jansman, Frank G A, Desar, Ingrid M E, Lankheet, Nienke A G, Burger, David M, van Herpen, Carla M L, van Erp, Nielka P
Published in The lancet oncology (01.06.2019)
Published in The lancet oncology (01.06.2019)
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Dasatinib in combination with fludarabine in patients with refractory chronic lymphocytic leukemia: A multicenter phase 2 study
Kater, Arnon P, Spiering, Marjolein, Liu, Roberto D, Doreen te Raa, G, Slinger, E, Tonino, Sanne H, Beckers, Marielle M, Daenen, Simon, Doorduijn, Jeanette K, Lankheet, Nienke A.G, Luijks, Dieuwertje M, Eldering, Eric, van Oers, Marinus H.J
Published in Leukemia research (01.01.2014)
Published in Leukemia research (01.01.2014)
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Journal Article
Phase 1 Study of Combination Treatment with PTK 787/ZK 222584 and Cetuximab for Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics Analysis1
Langenberg, Marlies HG, Witteveen, Petronella O, Lankheet, Nienke AG, Roodhart, Jeanine ML, Rosing, Hilde, van den Heuvel, Ingeborg JGM, Beijnen, Jos H, Voest, Emile E
Published in Neoplasia (New York, N.Y.) (01.02.2010)
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Published in Neoplasia (New York, N.Y.) (01.02.2010)
Journal Article
Relatively mild symptoms after an olanzapine intoxication in a 2-year-old girl with excessively high serum levels
Lankheet, Nienke A G, Padberg, Roos D, de Kluiver, Evelyne M, Wilhelm, Abraham J, van Woensel, Job B M, Beijnen, Jos H, Huitema, Alwin D R
Published in Journal of child and adolescent psychopharmacology (01.02.2011)
Published in Journal of child and adolescent psychopharmacology (01.02.2011)
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