The potential of PARP as a therapeutic target across pediatric solid malignancies
Keller, Kaylee M, Koetsier, Joost, Schild, Linda, Amo-Addae, Vicky, Eising, Selma, van den Handel, Kim, Ober, Kimberley, Koopmans, Bianca, Essing, Anke, van den Boogaard, Marlinde L, Langenberg, Karin P S, Jäger, Natalie, Kool, Marcel, Pfister, Stefan, Dolman, M Emmy M, Molenaar, Jan J, van Hooff, Sander R
Published in BMC cancer (05.04.2023)
Published in BMC cancer (05.04.2023)
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Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
Calandrini, Camilla, van Hooff, Sander R., Paassen, Irene, Ayyildiz, Dilara, Derakhshan, Sepide, Dolman, M. Emmy M., Langenberg, Karin P.S., van de Ven, Marieke, de Heus, Cecilia, Liv, Nalan, Kool, Marcel, de Krijger, Ronald R., Tytgat, Godelieve A.M., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., Drost, Jarno
Published in Cell reports (Cambridge) (24.08.2021)
Published in Cell reports (Cambridge) (24.08.2021)
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The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets
van Tilburg, Cornelis M, Pfaff, Elke, Pajtler, Kristian W, Langenberg, Karin P S, Fiesel, Petra, Jones, Barbara C, Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D, Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, von Stackelberg, Arend, Kulozik, Andreas E, Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan-Henning, Fleischhack, Gudrun, Tippelt, Stephan, von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M, von Bueren, André O, Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert, Westermann, Frank, Fischer, Matthias, Eggert, Angelika, Burkhardt, Birgit, Wößmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Frühwald, Michael C, Schneider, Dominik T, Brecht, Ines B, Ketteler, Petra, Fulda, Simone, Koscielniak, Ewa, Meister, Michael T, Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Øra, Ingrid, Hutter, Caroline, Gerber, Nicolas U, Lohi, Olli, Kazanowska, Bernarda, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C Michel, Milde, Till, Jäger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix, von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T W, Molenaar, Jan J, Capper, David, Pfister, Stefan M, Witt, Olaf
Published in Cancer discovery (01.11.2021)
Published in Cancer discovery (01.11.2021)
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Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
Meister, Michael T, Groot Koerkamp, Marian J A, de Souza, Terezinha, Breunis, Willemijn B, Frazer‐Mendelewska, Ewa, Brok, Mariël, DeMartino, Jeff, Manders, Freek, Calandrini, Camilla, Kerstens, Hinri H D, Janse, Alex, Dolman, M Emmy M, Eising, Selma, Langenberg, Karin P S, van Tuil, Marc, Knops, Rutger R G, van Scheltinga, Sheila Terwisscha, Hiemcke‐Jiwa, Laura S, Flucke, Uta, Merks, Johannes H M, van Noesel, Max M, Tops, Bastiaan B J, Hehir‐Kwa, Jayne Y, Kemmeren, Patrick, Molenaar, Jan J, van de Wetering, Marc, van Boxtel, Ruben, Drost, Jarno, Holstege, Frank C P
Published in EMBO molecular medicine (10.10.2022)
Published in EMBO molecular medicine (10.10.2022)
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Myeloproliferative Neoplasm Driven by ETV6-ABL1 in an Adolescent with Recent History of Burkitt Leukemia
Renzi, Samuele, Algawahmed, Fatimah, Davidson, Scott, Langenberg, Karin P S, Fuligni, Fabio, Ali, Salah, Anderson, Nathaniel, Brunga, Ledia, Bartram, Jack, Abdelhaleem, Mohamed, Naqvi, Ahmed, Beimnet, Kassa, Schuh, Andre, Tierens, Anne, Malkin, David, Shlien, Adam, Shago, Mary, Villani, Anita
Published in Current oncology (Toronto) (21.06.2023)
Published in Current oncology (Toronto) (21.06.2023)
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Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm
Bakhuizen, Jette J, Hopman, Saskia M J, Bosscha, Machteld I, Dommering, Charlotte J, van den Heuvel-Eibrink, Marry M, Hol, Janna A, Kester, Lennart A, Koudijs, Marco J, Langenberg, Karin P S, Loeffen, Jan L C, van der Lugt, Jasper, Moll, Annette C, van Noesel, Max M, Smetsers, Stephanie E, de Vos-Kerkhof, Evelien, Merks, Johannes H M, Kuiper, Roland P, Jongmans, Marjolijn C J
Published in JAMA network open (01.02.2023)
Published in JAMA network open (01.02.2023)
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Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
Kildisiute, Gerda, Kholosy, Waleed M, Young, Matthew D, Roberts, Kenny, Elmentaite, Rasa, van Hooff, Sander R, Pacyna, Clarissa N, Khabirova, Eleonora, Piapi, Alice, Thevanesan, Christine, Bugallo-Blanco, Eva, Burke, Christina, Mamanova, Lira, Keller, Kaylee M, Langenberg-Ververgaert, Karin P S, Lijnzaad, Philip, Margaritis, Thanasis, Holstege, Frank C P, Tas, Michelle L, Wijnen, Marc H W A, van Noesel, Max M, Del Valle, Ignacio, Barone, Giuseppe, van der Linden, Reinier, Duncan, Catriona, Anderson, John, Achermann, John C, Haniffa, Muzlifah, Teichmann, Sarah A, Rampling, Dyanne, Sebire, Neil J, He, Xiaoling, de Krijger, Ronald R, Barker, Roger A, Meyer, Kerstin B, Bayraktar, Omer, Straathof, Karin, Molenaar, Jan J, Behjati, Sam
Published in Science advances (05.02.2021)
Published in Science advances (05.02.2021)
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Case series on clinical applications of liquid biopsy in pediatric solid tumors: towards improved diagnostics and disease monitoring
Gelineau, Nina U, van Barneveld, Astrid, Samim, Atia, Van Zogchel, Lieke, Lak, Nathalie, Tas, Michelle L, Matser, Yvette, Mavinkurve-Groothuis, Annelies M C, van Grotel, Martine, Zsiros, Jószef, van Eijkelenburg, Natasha K A, Knops, Rutger R G, van Ewijk, Roelof, Langenberg, Karin P S, Krijger, Ronald De, Hiemcke-Jiwa, Laura S, Van Paemel, Ruben, Cornelli, Lotte, De Preter, Katleen, De Wilde, Bram, Van Der Schoot, Ellen, Tytgat, Godelieve
Published in Frontiers in oncology (17.08.2023)
Published in Frontiers in oncology (17.08.2023)
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Non‐rhabdomyosarcoma soft tissue sarcomas diagnosed in patients at a young age. An overview of clinical, pathological, and molecular findings
Renzi, Samuele, Cullinan, Noelle, Cohen‐Gogo, Sarah, Langenberg‐Ververgaert, Karin, Michaeli, Orli, Alkendi, Jalila, Kanwar, Nisha, Lo, Winnie, Villani, Anita, Shlien, Adam, Malkin, David, Ryan, Anne L., Gallinger, Bailey, Ingley, Katrina, Hopyan, Sevan, Gupta, Abha, Chami, Rose
Published in Pediatric blood & cancer (01.08.2021)
Published in Pediatric blood & cancer (01.08.2021)
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Oncogenic and immunological targets for matched therapy of pediatric blood cancer patients: Dutch iTHER study experience
Boer, Judith M., Ilan, Uri, Boeree, Aurélie, Langenberg, Karin P. S., Koster, Jan, Koudijs, Marco J., Hehir‐Kwa, Jayne Y., Nierkens, Stefan, Rossi, Corinne, Molenaar, Jan J., Goemans, Bianca F., Boer, Monique L., Zwaan, C. Michel
Published in HemaSphere (01.07.2024)
Published in HemaSphere (01.07.2024)
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Outcome of Children and Adolescents With Relapsed/Refractory/Progressive Malignancies Treated With Molecularly Informed Targeted Drugs in the Pediatric Precision Oncology Registry INFORM
Heipertz, Anna-Elisa, Pajtler, Kristian W, Pfaff, Elke, Schramm, Kathrin, Blattner-Johnson, Mirjam, Milde, Till, Jones, Barbara C, Zuliani, Cecilia, Hutter, Caroline, Lohi, Olli, Kattamis, Antonis, Dachowska-Kalwak, Iwona, Nilsson, Anna, Gerber, Nicolas U, Langenberg, Karin P S, Goemans, Bianca, Zwaan, C Michel, Molenaar, Jan J, Jäger, Natalie, Dirksen, Uta, Witt, Ruth, Pfister, Stefan M, Jones, David T W, Kopp-Schneider, Annette, Witt, Olaf, van Tilburg, Cornelis M
Published in JCO precision oncology (01.01.2023)
Published in JCO precision oncology (01.01.2023)
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mRNA Expression Level of ALK in Neuroblastoma Is Associated with Histological Subtype, ALK Mutations and ALK Immunohistochemical Protein Expression
Bruinsma, Rixt S., Fiocco, Marta F., de Leng, Wendy W. J., Kester, Lennart A., Langenberg, Karin P. S., Tytgat, Godelieve A. M., van Noesel, Max M., Wijnen, Marc H. W. A., van der Steeg, Alida F. W., de Krijger, Ronald R.
Published in Journal of Molecular Pathology (01.08.2024)
Published in Journal of Molecular Pathology (01.08.2024)
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GMP Synthetase Stimulates Histone H2B Deubiquitylation by the Epigenetic Silencer USP7
van der Knaap, Jan A., Kumar, B.R. Prashanth, Moshkin, Yuri M., Langenberg, Karin, Krijgsveld, Jeroen, Heck, Albert J.R., Karch, François, Verrijzer, C. Peter
Published in Molecular cell (04.03.2005)
Published in Molecular cell (04.03.2005)
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Biosynthetic Enzyme GMP Synthetase Cooperates with Ubiquitin-Specific Protease 7 in Transcriptional Regulation of Ecdysteroid Target Genes
van der Knaap, Jan A., Kozhevnikova, Elena, Langenberg, Karin, Moshkin, Yuri M., Verrijzer, C. Peter
Published in Molecular and Cellular Biology (01.02.2010)
Published in Molecular and Cellular Biology (01.02.2010)
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MYCN Amplified Relapse Following Resolution of MYCN Nonamplified 4S Neuroblastoma With Placental Involvement: A Case Report and Review of the Literature
Langenberg-Ververgaert, Karin P S, Renzi, Samuele, Chung, Catherine T, Shago, Mary, Lo, Winnie, Davidson, Scott, Villani, Anita, Baruchel, Sylvain, Irwin, Meredith S, Morgenstern, Daniel A
Published in Journal of pediatric hematology/oncology (01.07.2019)
Published in Journal of pediatric hematology/oncology (01.07.2019)
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Chemotherapy-Colchicine Interaction in a Child with Familial Mediterranean Fever and Hodgkin Lymphoma
Langenberg-Ververgaert, Karin P S, Laxer, Ronald M, Punnett, Angela S, Dupuis, L Lee, Finkelstein, Yaron, Abla, Oussama
Published in Mediterranean journal of hematology and infectious diseases (01.03.2018)
Published in Mediterranean journal of hematology and infectious diseases (01.03.2018)
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The Transcriptional Coactivator SAYP Is a Trithorax Group Signature Subunit of the PBAP Chromatin Remodeling Complex
Chalkley, Gillian E., Moshkin, Yuri M., Langenberg, Karin, Bezstarosti, Karel, Blastyak, Andras, Gyurkovics, Henrik, Demmers, Jeroen A. A., Verrijzer, C. Peter
Published in Molecular and Cellular Biology (01.05.2008)
Published in Molecular and Cellular Biology (01.05.2008)
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