Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties and biological activity
Blaazer, Antoni R., Lange, Jos H.M., van der Neut, Martina A.W., Mulder, Arie, den Boon, Femke S., Werkman, Taco R., Kruse, Chris G., Wadman, Wytse J.
Published in European journal of medicinal chemistry (01.10.2011)
Published in European journal of medicinal chemistry (01.10.2011)
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Journal Article
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism
Lange, Jos H. M, Coolen, Hein K. A. C, van der Neut, Martina A. W, Borst, Alice J. M, Stork, Bob, Verveer, Peter C, Kruse, Chris G
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Journal Article
Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB1 Cannabinoid Receptor Antagonists
Lange, Jos H. M, van Stuivenberg, Herman H, Coolen, Hein K. A. C, Adolfs, Tiny J. P, McCreary, Andrew C, Keizer, Hiskias G, Wals, Henri C, Veerman, Willem, Borst, Alice J. M, de Looff, Wouter, Verveer, Peter C, Kruse, Chris G
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors
Lange, Jos H.M., Venhorst, Jennifer, van Dongen, Maria J.P., Frankena, Jurjen, Bassissi, Firas, de Bruin, Natasja M.W.J., Besten, Cathaline den, de Beer, Stephanie B.A., Oostenbrink, Chris, Markova, Natalia, Kruse, Chris G.
Published in European journal of medicinal chemistry (01.10.2011)
Published in European journal of medicinal chemistry (01.10.2011)
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Journal Article
A novel atom-efficient, one-pot synthesis of sulfonylguanidines and sulfamoylguanidines
Lange, Jos H.M., Verhoog, Stefan, Sanders, Hans J., van Loevezijn, Arnold, Kruse, Chris G.
Published in Tetrahedron letters (22.06.2011)
Published in Tetrahedron letters (22.06.2011)
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Journal Article
Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, VAN VLIET, Bernard J, WALS, Henri C, KUIL, Gijs D, BORST, Alice J. M, MULDER, Arie, DEN HARTOG, Arnold P, ZILAOUT, Hicham, GOUTIER, Wouter, VAN STUIVENBERG, Herman H
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists
LANGE, Jos H. M, ATTALI, Amos, VAN DER NEUT, Martina A. W, WALS, Henri C, MULDER, Arie, ZILAOUT, Hicham, DUURSMA, Ate, VAN AKEN, Hans H. M, VAN VLIET, Bernard J
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, BORST, Alice J. M, YILDIRIM, Mahmut, VAN STUIVENBERG, Herman H, VAN VLIET, Bernard J, KRUSE, Chris G
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Principal Component Analysis Differentiates the Receptor Binding Profiles of Three Antipsychotic Drug Candidates from Current Antipsychotic Drugs
Lange, Jos H. M, Reinders, Jan-Hendrik, Tolboom, Jeroen T. B. M, Glennon, Jeffrey C, Coolen, Hein K. A. C, Kruse, Chris G
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
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Journal Article
Allosteric Inhibition of the Neuropeptidase Neurolysin
Hines, Christina S., Ray, Kallol, Schmidt, Jack J., Xiong, Fei, Feenstra, Rolf W., Pras-Raves, Mia, de Moes, Jan Peter, Lange, Jos H.M., Melikishvili, Manana, Fried, Michael G., Mortenson, Paul, Charlton, Michael, Patel, Yogendra, Courtney, Stephen M., Kruse, Chris G., Rodgers, David W.
Published in The Journal of biological chemistry (19.12.2014)
Published in The Journal of biological chemistry (19.12.2014)
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Journal Article
Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB1 Cannabinoid Receptor Antagonists
Lange, Jos H. M, Coolen, Hein K. A. C, van Stuivenberg, Herman H, Dijksman, Jessica A. R, Herremans, Arnoud H. J, Ronken, Eric, Keizer, Hiskias G, Tipker, Koos, McCreary, Andrew C, Veerman, Willem, Wals, Henri C, Stork, Bob, Verveer, Peter C, den Hartog, Arnold P, de Jong, Natasja M. J, Adolfs, Tiny J. P, Hoogendoorn, Jan, Kruse, Chris G
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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Journal Article
Optimization of N′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I., Lange, Jos H.M., de Looff, Wouter, Henzen, Remco, de Vries, Jelle, van de Woestijne, Rob P., den Hartog, Arnold P., Verhoog, Stefan, van der Neut, Martina A.W., de Bruin, Natasja M.W.J., Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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Journal Article
An expedient atom-efficient synthesis of the cannabinoid CB1 receptor inverse agonist ibipinabant
Lange, Jos H. M., Sanders, Hans J., van Rheenen, Jeroen
Published in Tetrahedron letters (23.03.2011)
Published in Tetrahedron letters (23.03.2011)
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Journal Article
Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB1 receptor antagonists
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, DEN HARTOG, Arnold P, WALS, Henri C, HOOGENDOORN, Jan, VAN STUIVENBERG, Herman H, VAN VLIET, Bernard J, KRUSE, Chris G
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity
LANGE, Jos H. M, VAN STUIVENBERG, Herman H, VEERMAN, Willem, WALS, Henri C, STORK, Bob, COOLEN, Hein K. A. C, MCCREARY, Andrew C, ADOLFS, Tiny J. P, KRUSE, Chris G
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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