Non‐linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix
Budda, Divakar, Gülave, Berfin, Hasselt, J. G. Coen, Lange, Elizabeth C. M.
Published in British journal of pharmacology (01.10.2024)
Published in British journal of pharmacology (01.10.2024)
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Journal Article
The need for mathematical modelling of spatial drug distribution within the brain
Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C M
Published in Fluids and barriers of the CNS (16.05.2019)
Published in Fluids and barriers of the CNS (16.05.2019)
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Journal Article
Utility of CSF in translational neuroscience
de Lange, Elizabeth C. M.
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2013)
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2013)
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Journal Article
A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations
Yamamoto, Yumi, Välitalo, Pyry A., van den Berg, Dirk-Jan, Hartman, Robin, van den Brink, Willem, Wong, Yin Cheong, Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Bakshi, Suruchi, Aranzana-Climent, Vincent, Marchand, Sandrine, Dahyot-Fizelier, Claire, Couet, William, Danhof, Meindert, van Hasselt, Johan G. C., de Lange, Elizabeth C. M.
Published in Pharmaceutical research (01.02.2017)
Published in Pharmaceutical research (01.02.2017)
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Journal Article
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice
Saleh, Mohammed A. A., Gülave, Berfin, Campagne, Olivia, Stewart, Clinton F., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.
Published in Pharmaceutical research (01.11.2023)
Published in Pharmaceutical research (01.11.2023)
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Journal Article
Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model
Saleh, Mohammed A. A., Bloemberg, Julia S., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.
Published in Pharmaceutical research (01.07.2022)
Published in Pharmaceutical research (01.07.2022)
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Journal Article
Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations
Saleh, Mohammed A. A., Loo, Chi Fong, Elassaiss-Schaap, Jeroen, De Lange, Elizabeth C. M.
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2021)
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2021)
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Journal Article
Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis
Danhof, Meindert, de Jongh, Joost, De Lange, Elizabeth C M, Della Pasqua, Oscar, Ploeger, Bart A, Voskuyl, Rob A
Published in Annual review of pharmacology and toxicology (01.01.2007)
Published in Annual review of pharmacology and toxicology (01.01.2007)
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Journal Article
Next-generation biomarker discovery in Alzheimer's disease using metabolomics - from animal to human studies
Hurtado, Marina Ollé, Kohler, Isabelle, de Lange, Elizabeth CM
Published in Bioanalysis (01.09.2018)
Published in Bioanalysis (01.09.2018)
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Journal Article
In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, Graaf, Piet Hein, Danhof, Meindert, Fernández‐Montalván, Amaury, Witt, Gesa, Lange, Elizabeth C M
Published in British journal of pharmacology (01.11.2018)
Published in British journal of pharmacology (01.11.2018)
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Journal Article
Revisiting atenolol as a low passive permeability marker
Chen, Xiaomei, Slättengren, Tim, de Lange, Elizabeth C M, Smith, David E, Hammarlund-Udenaes, Margareta
Published in Fluids and barriers of the CNS (31.10.2017)
Published in Fluids and barriers of the CNS (31.10.2017)
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Journal Article