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Benjamin, Don, Robay, Dimitri, Hindupur, Sravanth K., Pohlmann, Jens, Colombi, Marco, El-Shemerly, Mahmoud Y., Maira, Sauveur-Michel, Moroni, Christoph, Lane, Heidi A., Hall, Michael N.
Published in Cell reports (Cambridge) (11.12.2018)
Published in Cell reports (Cambridge) (11.12.2018)
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Phase II Randomized Study of Neoadjuvant Everolimus Plus Letrozole Compared With Placebo Plus Letrozole in Patients With Estrogen Receptor–Positive Breast Cancer
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Published in Journal of clinical oncology (01.06.2009)
Published in Journal of clinical oncology (01.06.2009)
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Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral Mammalian Target of Rapamycin Inhibitor Everolimus in Patients With Advanced Solid Tumors
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Published in Journal of clinical oncology (01.04.2008)
Published in Journal of clinical oncology (01.04.2008)
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Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function
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Published in The Journal of neuroscience (21.05.2008)
Published in The Journal of neuroscience (21.05.2008)
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Dose- and Schedule-Dependent Inhibition of the Mammalian Target of Rapamycin Pathway With Everolimus: A Phase I Tumor Pharmacodynamic Study in Patients With Advanced Solid Tumors
TABERNERO, Josep, ROJO, Federico, SHAND, Nicholas, MACARULLA, Teresa, RAMOS, Francisco Javier, DIMITRIJEVIC, Sasa, ZOELLNER, Ulrike, TANG, Pui, STUMM, Michael, LANE, Heidi A, LEBWOHL, David, BASELGA, José, CALVO, Emiliano, BURNS, Howard, JUDSON, Ian, HAZELL, Katharine, MARTINELLI, Erika, Y CAJAL, Santiago Ramon, JONES, Suzanne, VIDAL, Laura
Published in Journal of clinical oncology (01.04.2008)
Published in Journal of clinical oncology (01.04.2008)
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EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesis
Bergès, Raphaël, Tchoghandjian, Aurélie, Sergé, Arnauld, Honoré, Stéphane, Figarella-Branger, Dominique, Bachmann, Felix, Lane, Heidi A, Braguer, Diane
Published in Oncotarget (25.02.2020)
Published in Oncotarget (25.02.2020)
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Young adult outcomes of childhood prophylaxis for severe hemophilia A: results of the Joint Outcome Continuation Study
Warren, Beth Boulden, Thornhill, Dianne, Stein, Jill, Fadell, Michael, Ingram, J. David, Funk, Sharon, Norton, Kristi L., Lane, Heidi D., Bennett, Carolyn M., Dunn, Amy, Recht, Michael, Shapiro, Amy, Manco-Johnson, Marilyn J.
Published in Blood advances (09.06.2020)
Published in Blood advances (09.06.2020)
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Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
Brachmann, Saskia M, Hofmann, Irmgard, Schnell, Christian, Fritsch, Christine, Wee, Susan, Lane, Heidi, Wang, Shaowen, Garcia-Echeverria, Carlos, Maira, Sauveur-Michel
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2009)
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The fibroblast growth factor receptor inhibitor, derazantinib, has strong efficacy in human gastric tumor models and synergizes with paclitaxel in vivo
McSheehy, Paul M J, Forster-Gross, Nicole, El Shemerly, Mahmoud, Bachmann, Felix, Roceri, Mila, Hermann, Norbert, Spickermann, Jochen, Kellenberger, Laurenz, Lane, Heidi A
Published in Anti-cancer drugs (01.04.2023)
Published in Anti-cancer drugs (01.04.2023)
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Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition
Breuleux, Madlaina, Klopfenstein, Matthieu, Stephan, Christine, Doughty, Cheryl A, Barys, Louise, Maira, Saveur-Michel, Kwiatkowski, David, Lane, Heidi A
Published in Molecular cancer therapeutics (01.04.2009)
Published in Molecular cancer therapeutics (01.04.2009)
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Identifying Optimal Biologic Doses of Everolimus (RAD001) in Patients With Cancer Based on the Modeling of Preclinical and Clinical Pharmacokinetic and Pharmacodynamic Data
TANAKA, Chiaki, O'REILLY, Terence, HATTENBERGER, Marc, THOMAS, George, LANE, Heidi A, KOVARIK, John M, SHAND, Nicholas, HAZELL, Katharine, JUDSON, Ian, RAYMOND, Eric, ZUMSTEIN-MECKER, Sabine, STEPHAN, Christine, BOULAY, Anne
Published in Journal of clinical oncology (01.04.2008)
Published in Journal of clinical oncology (01.04.2008)
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mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor
Lane, Heidi A, Wood, Jeanette M, McSheehy, Paul M J, Allegrini, Peter R, Boulay, Anne, Brueggen, Joseph, Littlewood-Evans, Amanda, Maira, Sauveur-Michel, Martiny-Baron, Georg, Schnell, Christian R, Sini, Patrizia, O'Reilly, Terence
Published in Clinical cancer research (01.03.2009)
Published in Clinical cancer research (01.03.2009)
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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
O'REILLY, Kathryn E, ROJO, Fredi, BASELGA, Jose, ROSEN, Neal, SHE, Qing-Bai, SOLIT, David, MILLS, Gordon B, SMITH, Debra, LANE, Heidi, HOFMANN, Francesco, HICKLIN, Daniel J, LUDWIG, Dale L
Published in Cancer research (Chicago, Ill.) (01.02.2006)
Published in Cancer research (Chicago, Ill.) (01.02.2006)
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Derazantinib, a fibroblast growth factor receptor inhibitor, inhibits colony-stimulating factor receptor-1 in macrophages and tumor cells and in combination with a murine programmed cell death ligand-1-antibody activates the immune environment of murine syngeneic tumor models
El Shemerly, Mahmoud, Zanini, Elisa, Lecoultre, Marc, Walker, Paul R, Kellenberger, Laurenz, Lane, Heidi A, McSheehy, Paul M J
Published in Anti-cancer drugs (01.10.2023)
Published in Anti-cancer drugs (01.10.2023)
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The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation
Beuvink, Iwan, Boulay, Anne, Fumagalli, Stefano, Zilbermann, Frederic, Ruetz, Stephan, O’Reilly, Terence, Natt, Francois, Hall, Jonathan, Lane, Heidi A., Thomas, George
Published in Cell (25.03.2005)
Published in Cell (25.03.2005)
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Dual Inhibition of mTOR and Estrogen Receptor Signaling In vitro Induces Cell Death in Models of Breast Cancer
Boulay, Anne, Rudloff, Joelle, Ye, Jingjing, Zumstein-Mecker, Sabine, O'Reilly, Terence, Evans, Dean B, Chen, Shiuan, Lane, Heidi A
Published in Clinical cancer research (15.07.2005)
Published in Clinical cancer research (15.07.2005)
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Dual TTK/PLK1 inhibition has potent anticancer activity in TNBC as monotherapy and in combination
Zanini, Elisa, Forster-Gross, Nicole, Bachmann, Felix, Brüngger, Adrian, McSheehy, Paul, Litherland, Karine, Burger, Karin, Groner, Anna C, Roceri, Mila, Bury, Luc, Stieger, Martin, Willemsen-Seegers, Nicole, de Man, Jos, Vu-Pham, Diep, van Riel, Helma W E, Zaman, Guido J R, Buijsman, Rogier C, Kellenberger, Laurenz, Lane, Heidi A
Published in Frontiers in oncology (09.08.2024)
Published in Frontiers in oncology (09.08.2024)
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Phase 1/2a trial of intravenous BAL101553, a novel controller of the spindle assembly checkpoint, in advanced solid tumours
Kristeleit, Rebecca, Evans, Jeffry, Molife, L. Rhoda, Tunariu, Nina, Shaw, Heather, Slater, Sarah, Haris, Noor R. Md, Brown, Nicholas F., Forster, Martin D., Diamantis, Nikolaos, Rulach, Robert, Greystoke, Alastair, Asghar, Uzma, Rata, Mihaela, Anderson, Stephanie, Bachmann, Felix, Hannah, Alison, Kaindl, Thomas, Lane, Heidi A., Larger, Patrice J., Schmitt-Hoffmann, Anne, Engelhardt, Marc, Tzankov, Alexandar, Plummer, Ruth, Lopez, Juanita
Published in British journal of cancer (27.10.2020)
Published in British journal of cancer (27.10.2020)
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