Discovery of Trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as Potent, Orally Bioavailable TGR5 (GPBAR1) Agonists: Structure–Activity Relationships, Lead Optimization, and Chronic In Vivo Efficacy
Phillips, Dean P, Gao, Wenqi, Yang, Yang, Zhang, Guobao, Lerario, Isabelle K, Lau, Thomas L, Jiang, Jiqing, Wang, Xia, Nguyen, Deborah G, Bhat, B. Ganesh, Trotter, Carol, Sullivan, Heather, Welzel, Gustav, Landry, Jannine, Chen, Yali, Joseph, Sean B, Li, Chun, Gordon, W. Perry, Richmond, Wendy, Johnson, Kevin, Bretz, Angela, Bursulaya, Badry, Pan, Shifeng, McNamara, Peter, Seidel, H. Martin
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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