E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1
Kwanten, Bert, Deconick, Tine, Walker, Christopher, Wang, Feng, Landesman, Yosef, Daelemans, Dirk
Published in Biomedicine & pharmacotherapy (01.04.2023)
Published in Biomedicine & pharmacotherapy (01.04.2023)
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The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia
Vercruysse, Thomas, De Bie, Jolien, Neggers, Jasper E, Jacquemyn, Maarten, Vanstreels, Els, Schmid-Burgk, Jonathan L, Hornung, Veit, Baloglu, Erkan, Landesman, Yosef, Senapedis, William, Shacham, Sharon, Dagklis, Antonis, Cools, Jan, Daelemans, Dirk
Published in Clinical cancer research (15.05.2017)
Published in Clinical cancer research (15.05.2017)
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Therapeutic Potential of Targeting PAK Signaling
Senapedis, William, Crochiere, Marsha, Baloglu, Erkan, Landesman, Yosef
Published in Anti-cancer agents in medicinal chemistry (01.01.2016)
Published in Anti-cancer agents in medicinal chemistry (01.01.2016)
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Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma
Aboukameel, Amro, Muqbil, Irfana, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Philip, Philip A, Mohammad, Ramzi M, Azmi, Asfar S
Published in Molecular cancer therapeutics (01.01.2017)
Published in Molecular cancer therapeutics (01.01.2017)
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Selinexor decreases HIF-1α via inhibition of CRM1 in human osteosarcoma and hepatoma cells associated with an increased radiosensitivity
von Fallois, Moritz, Kosyna, Friederike Katharina, Mandl, Markus, Landesman, Yosef, Dunst, Jürgen, Depping, Reinhard
Published in Journal of cancer research and clinical oncology (01.07.2021)
Published in Journal of cancer research and clinical oncology (01.07.2021)
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Anti-tumor activity of selinexor in combination with antineoplastic agents in chronic lymphocytic leukemia
Vitale, Candida, Griggio, Valentina, Todaro, Maria, Riganti, Chiara, Jones, Rebecca, Boccellato, Elia, Perutelli, Francesca, Arruga, Francesca, Vaisitti, Tiziana, Efremov, Dimitar G., Deaglio, Silvia, Landesman, Yosef, Bruno, Benedetto, Coscia, Marta
Published in Scientific reports (07.10.2023)
Published in Scientific reports (07.10.2023)
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Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis
Machlus, Kellie R., Wu, Stephen K., Vijey, Prakrith, Soussou, Thomas S., Liu, Zhi-Jian, Shacham, Eran, Unger, T.J., Kashyap, Trinayan, Klebanov, Boris, Sola-Visner, Martha, Crochiere, Marsha, Italiano, Joseph E., Landesman, Yosef
Published in Blood (31.08.2017)
Published in Blood (31.08.2017)
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Targeting XPO1 and PAK4 in 8505C Anaplastic Thyroid Cancer Cells: Putative Implications for Overcoming Lenvatinib Therapy Resistance
Khan, Husain Yar, Ge, James, Nagasaka, Misako, Aboukameel, Amro, Mpilla, Gabriel, Muqbil, Irfana, Szlaczky, Mark, Chaker, Mahmoud, Baloglu, Erkan, Landesman, Yosef, Mohammad, Ramzi M, Azmi, Asfar S, Sukari, Ammar
Published in International journal of molecular sciences (29.12.2019)
Published in International journal of molecular sciences (29.12.2019)
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XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer
Cheng, Yan, Holloway, Michael P, Nguyen, Kevin, McCauley, Dilara, Landesman, Yosef, Kauffman, Michael G, Shacham, Sharon, Altura, Rachel A
Published in Molecular cancer therapeutics (01.03.2014)
Published in Molecular cancer therapeutics (01.03.2014)
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p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma
Qasim, Shawki L., Sierra, Laura, Shuck, Ryan, Kurenbekova, Lyazat, Patel, Tajhal D., Rajapakshe, Kimal, Wulff, Jade, Nakahata, Kengo, Kim, Ha Ram, Landesman, Yosef, Unger, T. J., Coarfa, Cristian, Yustein, Jason T.
Published in Oncogene (11.02.2021)
Published in Oncogene (11.02.2021)
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Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer
Chen, Ying, Camacho, Sandra Catalina, Silvers, Thomas R, Razak, Albiruni R A, Gabrail, Nashat Y, Gerecitano, John F, Kalir, Eva, Pereira, Elena, Evans, Brad R, Ramus, Susan J, Huang, Fei, Priedigkeit, Nolan, Rodriguez, Estefania, Donovan, Michael, Khan, Faisal, Kalir, Tamara, Sebra, Robert, Uzilov, Andrew, Chen, Rong, Sinha, Rileen, Halpert, Richard, Billaud, Jean-Noel, Shacham, Sharon, McCauley, Dilara, Landesman, Yosef, Rashal, Tami, Kauffman, Michael, Mirza, Mansoor R, Mau-Sørensen, Morten, Dottino, Peter, Martignetti, John A
Published in Clinical cancer research (15.03.2017)
Published in Clinical cancer research (15.03.2017)
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Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias
Walker, Christopher J., Oaks, Joshua J., Santhanam, Ramasamy, Neviani, Paolo, Harb, Jason G., Ferenchak, Gregory, Ellis, Justin J., Landesman, Yosef, Eisfeld, Ann-Kathrin, Gabrail, Nash Y., Smith, Carrie L., Caligiuri, Michael A., Hokland, Peter, Roy, Denis Claude, Reid, Alistair, Milojkovic, Dragana, Goldman, John M., Apperley, Jane, Garzon, Ramiro, Marcucci, Guido, Shacham, Sharon, Kauffman, Michael G., Perrotti, Danilo
Published in Blood (24.10.2013)
Published in Blood (24.10.2013)
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Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas
Jeitany, Maya, Prabhu, Aishvaryaa, Dakle, Pushkar, Pathak, Elina, Madan, Vikas, Kanojia, Deepika, Mukundan, Vineeth, Jiang, Yan Yi, Landesman, Yosef, Tam, Wai Leong, Kappei, Dennis, Koeffler, H. Phillip
Published in Cellular and molecular life sciences : CMLS (01.02.2021)
Published in Cellular and molecular life sciences : CMLS (01.02.2021)
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Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer
Sexton, Rachel, Mahdi, Zaid, Chaudhury, Rahman, Beydoun, Rafic, Aboukameel, Amro, Khan, Husain Y, Baloglu, Erkan, Senapedis, William, Landesman, Yosef, Tesfaye, Anteneh, Kim, Steve, Philip, Philip A, Azmi, Asfar S
Published in International journal of molecular sciences (28.09.2019)
Published in International journal of molecular sciences (28.09.2019)
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Selinexor, bortezomib, and dexamethasone (SVD) in heavily treated relapsed refractory multiple myeloma
Mouhieddine, Tarek H., Parekh, Samir, Cho, Hearn Jay, Richter, Joshua, DeCastro, Andrew, Shah, Jatin, Landesman, Yosef, Chari, Ajai, Jagannath, Sundar, Madduri, Deepu
Published in Annals of hematology (01.12.2021)
Published in Annals of hematology (01.12.2021)
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Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T-cell Effector Function in Mice: Implications for Combination with Immunotherapy
Tyler, Paul M, Servos, Mariah M, de Vries, Romy C, Klebanov, Boris, Kashyap, Trinayan, Sacham, Sharon, Landesman, Yosef, Dougan, Michael, Dougan, Stephanie K
Published in Molecular cancer therapeutics (01.03.2017)
Published in Molecular cancer therapeutics (01.03.2017)
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XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)
Gravina, Giovanni Luca, Tortoreto, Monica, Mancini, Andrea, Addis, Alessandro, Di Cesare, Ernesto, Lenzi, Andrea, Landesman, Yosef, McCauley, Dilara, Kauffman, Michael, Shacham, Sharon, Zaffaroni, Nadia, Festuccia, Claudio
Published in Journal of hematology and oncology (05.10.2014)
Published in Journal of hematology and oncology (05.10.2014)
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The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors
Farren, Matthew R, Hennessey, Rebecca C, Shakya, Reena, Elnaggar, Omar, Young, Gregory, Kendra, Kari, Landesman, Yosef, Elloul, Sivan, Crochiere, Marsha, Klebanov, Boris, Kashyap, Trinayan, Burd, Christin E, Lesinski, Gregory B
Published in Molecular cancer therapeutics (01.03.2017)
Published in Molecular cancer therapeutics (01.03.2017)
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Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma
Muz, Barbara, Azab, Feda, de la Puente, Pilar, Landesman, Yosef, Azab, Abdel Kareem
Published in Translational oncology (01.08.2017)
Published in Translational oncology (01.08.2017)
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