Glycosylation stabilizes hERG channels on the plasma membrane by decreasing proteolytic susceptibility
Lamothe, Shawn M, Hulbert, Maggie, Guo, Jun, Li, Wentao, Yang, Tonghua, Zhang, Shetuan
Published in The FASEB journal (01.04.2018)
Published in The FASEB journal (01.04.2018)
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Journal Article
Reducing agents facilitate membrane patch seal integrity and longevity
Das, Damayantee, Wong, Anson, Friedman, Timothy N, Kerr, Bradley J, Kurata, Harley T, Lamothe, Shawn M
Published in Channels (Austin, Tex.) (01.12.2024)
Published in Channels (Austin, Tex.) (01.12.2024)
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Journal Article
Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels
Lamothe, Shawn M, Sharmin, Nazlee, Silver, Grace, Satou, Motoyasu, Hao, Yubin, Tateno, Toru, Baronas, Victoria A, Kurata, Harley T
Published in eLife (09.11.2020)
Published in eLife (09.11.2020)
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Journal Article
Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2
Wang, Tingzhong, Hogan-Cann, Andrew, Kang, Yudi, Cui, Zhi, Guo, Jun, Yang, Tonghua, Lamothe, Shawn M, Li, Wentao, Ma, Aiqun, Fisher, John T, Zhang, Shetuan
Published in Molecular pharmacology (01.06.2014)
Published in Molecular pharmacology (01.06.2014)
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Journal Article
Febrile temperature facilitates hERG/IKr degradation through an altered K+ dependence
Zhao, Yan, MSc, Wang, Tingzhong, PhD, Guo, Jun, BM, Yang, Tonghua, BM, Li, Wentao, BSc, Koichopolos, Jennifer, BSc, Lamothe, Shawn M., MSc, Kang, Yudi, MSc, Ma, Aiqun, MD, Zhang, Shetuan, PhD
Published in Heart rhythm (01.10.2016)
Published in Heart rhythm (01.10.2016)
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Journal Article
Competition between Slc7a5 and LMAN2 for modulation of Kv1.2 gating
Das, Damayantee, Lamothe, Shawn M., Baronas, Victoria A., Kurata, Harley T.
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article
Modulation of heteromeric Kv1 channels by transmembrane lectins and redox
Wong, Anson, Lamothe, Shawn M., Baronas, Victoria A., Kurata, Harley T.
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article
Unmasking subtype-dependent susceptibility to C-type inactivation in mammalian Kv1 channels
Baronas, Victoria A., Wong, Anson, Das, Damayantee, Lamothe, Shawn M., Kurata, Harley T.
Published in Biophysical journal (16.07.2024)
Published in Biophysical journal (16.07.2024)
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Journal Article
Modulation of Kv1.2 redox-sensitive gating by the transmembrane lectin LMAN2
Lamothe, Shawn M., Das, Damayantee, Wong, Anson, Hao, Yubin, Baronas, Victoria A., Kurata, Harley T.
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
Kalyaanamoorthy, Subha, Lamothe, Shawn M, Hou, Xiaoqing, Moon, Tae Chul, Kurata, Harley T, Houghton, Michael, Barakat, Khaled H
Published in Scientific reports (01.10.2020)
Published in Scientific reports (01.10.2020)
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Journal Article
Anti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression
Szendrey, John, Lamothe, Shawn M, Vanner, Stephanie, Guo, Jun, Yang, Tonghua, Li, Wentao, Davis, Jordan, Joneja, Mala, Baranchuk, Adrian, Zhang, Shetuan
Published in Cardiovascular research (01.08.2019)
Published in Cardiovascular research (01.08.2019)
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Journal Article
Endoplasmic reticulum stress in the dorsal root ganglia regulates large‐conductance potassium channels and contributes to pain in a model of multiple sclerosis
Yousuf, Muhammad Saad, Samtleben, Samira, Lamothe, Shawn M., Friedman, Timothy N., Catuneanu, Ana, Thorburn, Kevin, Desai, Mansi, Tenorio, Gustavo, Schenk, Geert J., Ballanyi, Klaus, Kurata, Harley T., Simmen, Thomas, Kerr, Bradley J.
Published in The FASEB journal (01.09.2020)
Published in The FASEB journal (01.09.2020)
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Journal Article
The N terminus and transmembrane segment S1 of Kv1.5 can coassemble with the rest of the channel independently of the S1–S2 linkage
Lamothe, Shawn M., Hogan-Cann, Aja E., Li, Wentao, Guo, Jun, Yang, Tonghua, Tschirhart, Jared N., Zhang, Shetuan
Published in The Journal of biological chemistry (05.10.2018)
Published in The Journal of biological chemistry (05.10.2018)
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Journal Article
Hypoxia reduces mature hERG channels through calpain up-regulation
Lamothe, Shawn M, Song, WonJu, Guo, Jun, Li, Wentao, Yang, Tonghua, Baranchuk, Adrian, Graham, Charles H, Zhang, Shetuan
Published in The FASEB journal (01.11.2017)
Published in The FASEB journal (01.11.2017)
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Journal Article
Differential Regulation of Human Ether-à-Go-Go-Related Gene (hERG) Current and Expression by Activation of Protein Kinase C
Sutherland-Deveen, Morgan E, Wang, Tingzhong, Lamothe, Shawn M, Tschirhart, Jared N, Guo, Jun, Li, Wentao, Yang, Tonghua, Du, Yuan, Zhang, Shetuan
Published in Molecular pharmacology (01.07.2019)
Published in Molecular pharmacology (01.07.2019)
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Journal Article
Pore- and voltage sensor-targeted KCNQ openers have distinct state-dependent actions
Wang, Caroline K, Lamothe, Shawn M, Wang, Alice W, Yang, Runying Y, Kurata, Harley T
Published in The Journal of general physiology (03.12.2018)
Published in The Journal of general physiology (03.12.2018)
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Journal Article