Search Results - "Lam, Polo C.-H." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae

3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae

by Verma, Astha, Wong, Dawn M., Islam, Rafique, Tong, Fan, Ghavami, Maryam, Mutunga, James M., Slebodnick, Carla, Li, Jianyong, Viayna, Elisabet, Lam, Polo C.-H., Totrov, Maxim M., Bloomquist, Jeffrey R., Carlier, Paul R.
Published in Bioorganic & medicinal chemistry (15.03.2015)

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Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

by Dong, Maoqing, Xu, Xiequn, Ball, Alicja M, Makhoul, Joshua A, Lam, Polo C-H, Pinon, Delia I, Orry, Andrew, Sexton, Patrick M, Abagyan, Ruben, Miller, Laurence J
Published in The FASEB journal (01.12.2012)

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Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron)

Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron)

by Wong, Dawn M, Li, Jianyong, Chen, Qiao-Hong, Han, Qian, Mutunga, James M, Wysinski, Ania, Anderson, Troy D, Ding, Haizhen, Carpenetti, Tiffany L, Verma, Astha, Islam, Rafique, Paulson, Sally L, Lam, Polo C-H, Totrov, Maxim, Bloomquist, Jeffrey R, Carlier, Paul R
Published in PloS one (01.10.2012)

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Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer’s BACE1 inhibitors

Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer’s BACE1 inhibitors

by Monceaux, Christopher J, Hirata-Fukae, Chiho, Lam, Polo C.-H, Totrov, Maxim M, Matsuoka, Yasuji, Carlier, Paul R
Published in Bioorganic & medicinal chemistry letters (01.07.2011)

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Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor

Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor

by Gao, Fan, Harikumar, Kaleeckal G, Dong, Maoqing, Lam, Polo C-H, Sexton, Patrick M, Christopoulos, Arthur, Bordner, Andrew, Abagyan, Ruben, Miller, Laurence J
Published in Molecular pharmacology (01.08.2009)

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Ligand-biased ensemble receptor docking (LigBEnD): a hybrid ligand/receptor structure-based approach

Ligand-biased ensemble receptor docking (LigBEnD): a hybrid ligand/receptor structure-based approach

by Lam, Polo C.-H., Abagyan, Ruben, Totrov, Maxim
Published in Journal of computer-aided molecular design (01.01.2018)

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Elucidation of the Molecular Basis of Cholecystokinin Peptide Docking to Its Receptor Using Site-Specific Intrinsic Photoaffinity Labeling and Molecular Modeling

Elucidation of the Molecular Basis of Cholecystokinin Peptide Docking to Its Receptor Using Site-Specific Intrinsic Photoaffinity Labeling and Molecular Modeling

by Dong, Maoqing, Lam, Polo C.-H, Pinon, Delia I, Abagyan, Ruben, Miller, Laurence J
Published in Biochemistry (Easton) (16.06.2009)

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Secretin Occupies a Single Protomer of the Homodimeric Secretin Receptor Complex: INSIGHTS FROM PHOTOAFFINITY LABELING STUDIES USING DUAL SITES OF COVALENT ATTACHMENT

Secretin Occupies a Single Protomer of the Homodimeric Secretin Receptor Complex: INSIGHTS FROM PHOTOAFFINITY LABELING STUDIES USING DUAL SITES OF COVALENT ATTACHMENT

by Dong, Maoqing, Lam, Polo C.-H, Pinon, Delia I, Orry, Andrew, Sexton, Patrick M, Abagyan, Ruben, Miller, Laurence J
Published in The Journal of biological chemistry (26.03.2010)

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Spatial Approximation between Secretin Residue Five and the Third Extracellular Loop of Its Receptor Provides New Insight into the Molecular Basis of Natural Agonist Binding

Spatial Approximation between Secretin Residue Five and the Third Extracellular Loop of Its Receptor Provides New Insight into the Molecular Basis of Natural Agonist Binding

by Dong, Maoqing, Lam, Polo C-H, Pinon, Delia I, Sexton, Patrick M, Abagyan, Ruben, Miller, Laurence J
Published in Molecular pharmacology (01.08.2008)

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Hybrid receptor structure/ligand-based docking and activity prediction in ICM: development and evaluation in D3R Grand Challenge 3

Hybrid receptor structure/ligand-based docking and activity prediction in ICM: development and evaluation in D3R Grand Challenge 3

by Lam, Polo C.-H., Abagyan, Ruben, Totrov, Maxim
Published in Journal of computer-aided molecular design (01.01.2019)

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Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor

Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor

by Dong, Maoqing, Lam, Polo C-H, Gao, Fan, Hosohata, Keiko, Pinon, Delia I, Sexton, Patrick M, Abagyan, Ruben, Miller, Laurence J
Published in Molecular pharmacology (01.08.2007)

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Enantioselective Synthesis of “Quaternary” 1,4-Benzodiazepin-2-one Scaffolds via Memory of Chirality

Enantioselective Synthesis of “Quaternary” 1,4-Benzodiazepin-2-one Scaffolds via Memory of Chirality

by Carlier, Paul R, Zhao, Hongwu, DeGuzman, Joe, Lam, Polo C.-H
Published in Journal of the American Chemical Society (24.09.2003)

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Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex

Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex

by Desai, Aditya J, Lam, Polo C. H, Orry, Andrew, Abagyan, Ruben, Christopoulos, Arthur, Sexton, Patrick M, Miller, Laurence J
Published in Journal of medicinal chemistry (24.12.2015)

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Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling

Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling

by Miller, Laurence J., Chen, Quan, Lam, Polo C.-H., Pinon, Delia I., Sexton, Patrick M., Abagyan, Ruben, Dong, Maoqing
Published in The Journal of biological chemistry (06.05.2011)

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Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor

Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor

by Dong, Maoqing, Lam, Polo C.-H., Orry, Andrew, Sexton, Patrick M., Christopoulos, Arthur, Abagyan, Ruben, Miller, Laurence J.
Published in The Journal of biological chemistry (04.03.2016)

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Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore

Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore

by Dong, Maoqing, Lam, Polo C.-H., Pinon, Delia I., Hosohata, Keiko, Orry, Andrew, Sexton, Patrick M., Abagyan, Ruben, Miller, Laurence J.
Published in The Journal of biological chemistry (08.07.2011)

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Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding

Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding

by Dong, Maoqing, Vattelana, Ashton M, Lam, Polo C-H, Orry, Andrew J, Abagyan, Ruben, Christopoulos, Arthur, Sexton, Patrick M, Haines, David R, Miller, Laurence J
Published in Molecular pharmacology (01.01.2015)

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Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase

by Hartsel, Joshua A., Wong, Dawn M., Mutunga, James M., Ma, Ming, Anderson, Troy D., Wysinski, Ania, Islam, Rafique, Wong, Eric A., Paulson, Sally L., Li, Jianyong, Lam, Polo C.H., Totrov, Maxim M., Bloomquist, Jeffrey R., Carlier, Paul R.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)

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Catalytic Asymmetric Synthesis of Protected Tryptophan Regioisomers

Catalytic Asymmetric Synthesis of Protected Tryptophan Regioisomers

by Carlier, Paul R, Lam, Polo C.-H, Wong, Dawn M
Published in Journal of organic chemistry (23.08.2002)

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Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae

Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae

by Carlier, Paul R., Anderson, Troy D., Wong, Dawn M., Hsu, Danny C., Hartsel, Joshua, Ma, Ming, Wong, Eric A., Choudhury, Ranginee, Lam, Polo C.-H., Totrov, Maxim M., Bloomquist, Jeffrey R.
Published in Chemico-biological interactions (25.09.2008)

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