Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
Gilan, Omer, Rioja, Inmaculada, Knezevic, Kathy, Bell, Matthew J, Yeung, Miriam M, Harker, Nicola R, Lam, Enid Y N, Chung, Chun-Wa, Bamborough, Paul, Petretich, Massimo, Urh, Marjeta, Atkinson, Stephen J, Bassil, Anna K, Roberts, Emma J, Vassiliadis, Dane, Burr, Marian L, Preston, Alex G S, Wellaway, Christopher, Werner, Thilo, Gray, James R, Michon, Anne-Marie, Gobbetti, Thomas, Kumar, Vinod, Soden, Peter E, Haynes, Andrea, Vappiani, Johanna, Tough, David F, Taylor, Simon, Dawson, Sarah-Jane, Bantscheff, Marcus, Lindon, Matthew, Drewes, Gerard, Demont, Emmanuel H, Daniels, Danette L, Grandi, Paola, Prinjha, Rab K, Dawson, Mark A
Published in Science (American Association for the Advancement of Science) (24.04.2020)
Published in Science (American Association for the Advancement of Science) (24.04.2020)
Get full text
Journal Article
Inhibitory role of peroxisome proliferator‐activated receptor gamma in hepatocarcinogenesis in mice and in vitro
Yu, Jun, Shen, Bo, Chu, Eagle S. H., Teoh, Narci, Cheung, Kin‐Fai, Wu, Chung‐Wah, Wang, Shiyan, Lam, Cleo N. Y., Feng, Hai, Zhao, Junhong, Cheng, Alfred S. L., To, Ka‐Fai, Chan, Henry L. Y., Sung, Joseph J. Y.
Published in Hepatology (Baltimore, Md.) (01.06.2010)
Published in Hepatology (Baltimore, Md.) (01.06.2010)
Get full text
Journal Article
Non-genetic determinants of malignant clonal fitness at single-cell resolution
Fennell, Katie A., Vassiliadis, Dane, Lam, Enid Y. N., Martelotto, Luciano G., Balic, Jesse J., Hollizeck, Sebastian, Weber, Tom S., Semple, Timothy, Wang, Qing, Miles, Denise C., MacPherson, Laura, Chan, Yih-Chih, Guirguis, Andrew A., Kats, Lev M., Wong, Emily S., Dawson, Sarah-Jane, Naik, Shalin H., Dawson, Mark A.
Published in Nature (London) (06.01.2022)
Published in Nature (London) (06.01.2022)
Get full text
Journal Article
Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
Bell, Charles C., Fennell, Katie A., Chan, Yih-Chih, Rambow, Florian, Yeung, Miriam M., Vassiliadis, Dane, Lara, Luis, Yeh, Paul, Martelotto, Luciano G., Rogiers, Aljosja, Kremer, Brandon E., Barbash, Olena, Mohammad, Helai P., Johanson, Timothy M., Burr, Marian L., Dhar, Arindam, Karpinich, Natalie, Tian, Luyi, Tyler, Dean S., MacPherson, Laura, Shi, Junwei, Pinnawala, Nathan, Yew Fong, Chun, Papenfuss, Anthony T., Grimmond, Sean M., Dawson, Sarah-Jane, Allan, Rhys S., Kruger, Ryan G., Vakoc, Christopher R., Goode, David L., Naik, Shalin H., Gilan, Omer, Lam, Enid Y. N., Marine, Jean-Christophe, Prinjha, Rab K., Dawson, Mark A.
Published in Nature communications (20.06.2019)
Published in Nature communications (20.06.2019)
Get full text
Journal Article
Click chemistry enables preclinical evaluation of targeted epigenetic therapies
Tyler, Dean S., Vappiani, Johanna, Cañeque, Tatiana, Lam, Enid Y. N., Ward, Aoife, Gilan, Omer, Chan, Yih-Chih, Hienzsch, Antje, Rutkowska, Anna, Werner, Thilo, Wagner, Anne J., Lugo, Dave, Gregory, Richard, Molina, Cesar Ramirez, Garton, Neil, Wellaway, Christopher R., Jackson, Susan, MacPherson, Laura, Figueiredo, Margarida, Stolzenburg, Sabine, Bell, Charles C., House, Colin, Dawson, Sarah-Jane, Hawkins, Edwin D., Drewes, Gerard, Prinjha, Rab K., Rodriguez, Raphaël, Grandi, Paola, Dawson, Mark A.
Published in Science (American Association for the Advancement of Science) (30.06.2017)
Published in Science (American Association for the Advancement of Science) (30.06.2017)
Get full text
Journal Article
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
Burr, Marian L., Sparbier, Christina E., Chan, Yih-Chih, Williamson, James C., Woods, Katherine, Beavis, Paul A., Lam, Enid Y. N., Henderson, Melissa A., Bell, Charles C., Stolzenburg, Sabine, Gilan, Omer, Bloor, Stuart, Noori, Tahereh, Morgens, David W., Bassik, Michael C., Neeson, Paul J., Behren, Andreas, Darcy, Phillip K., Dawson, Sarah-Jane, Voskoboinik, Ilia, Trapani, Joseph A., Cebon, Jonathan, Lehner, Paul J., Dawson, Mark A.
Published in Nature (London) (07.09.2017)
Published in Nature (London) (07.09.2017)
Get full text
Journal Article
Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer
Cheung, Kin‐Fai, Lam, Cleo N. Y., Wu, Kaichun, Ng, Enders K. O., Chong, Wilson W. S., Cheng, Alfred S. L., To, Ka‐Fai, Fan, Daiming, Sung, Joseph J. Y., Yu, Jun
Published in Cancer (15.02.2012)
Published in Cancer (15.02.2012)
Get full text
Journal Article
HBO1 is required for the maintenance of leukaemia stem cells
MacPherson, Laura, Anokye, Juliana, Yeung, Miriam M., Lam, Enid Y. N., Chan, Yih-Chih, Weng, Chen-Fang, Yeh, Paul, Knezevic, Kathy, Butler, Miriam S., Hoegl, Annabelle, Chan, Kah-Lok, Burr, Marian L., Gearing, Linden J., Willson, Tracy, Liu, Joy, Choi, Jarny, Yang, Yuqing, Bilardi, Rebecca A., Falk, Hendrik, Nguyen, Nghi, Stupple, Paul A., Peat, Thomas S., Zhang, Ming, de Silva, Melanie, Carrasco-Pozo, Catalina, Avery, Vicky M., Khoo, Poh Sim, Dolezal, Olan, Dennis, Matthew L., Nuttall, Stewart, Surjadi, Regina, Newman, Janet, Ren, Bin, Leaver, David J., Sun, Yuxin, Baell, Jonathan B., Dovey, Oliver, Vassiliou, George S., Grebien, Florian, Dawson, Sarah-Jane, Street, Ian P., Monahan, Brendon J., Burns, Christopher J., Choudhary, Chunaram, Blewitt, Marnie E., Voss, Anne K., Thomas, Tim, Dawson, Mark A.
Published in Nature (London) (09.01.2020)
Published in Nature (London) (09.01.2020)
Get full text
Journal Article
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia
Gilan, Omer, Talarmain, Laure, Bell, Charles C., Neville, Daniel, Knezevic, Kathy, Ferguson, Daniel T., Boudes, Marion, Chan, Yih-Chih, Davidovich, Chen, Lam, Enid Y. N., Dawson, Mark A.
Published in Nature structural & molecular biology (01.10.2023)
Published in Nature structural & molecular biology (01.10.2023)
Get full text
Journal Article
Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
Sparbier, Christina E., Gillespie, Andrea, Gomez, Juliana, Kumari, Nishi, Motazedian, Ali, Chan, Kah Lok, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Popp, Sarah, Gough, Daniel J., Eckersley-Maslin, Melanie A., Dawson, Sarah-Jane, Lehner, Paul J., Sutherland, Kate D., Ernst, Patricia, McGeehan, Gerard M., Lam, Enid Y. N., Burr, Marian L., Dawson, Mark A.
Published in Nature cell biology (01.02.2023)
Published in Nature cell biology (01.02.2023)
Get full text
Journal Article
CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity
Watt, April C, Cejas, Paloma, DeCristo, Molly J, Metzger-Filho, Otto, Lam, Enid Y N, Qiu, Xintao, BrinJones, Haley, Kesten, Nikolas, Coulson, Rhiannon, Font-Tello, Alba, Lim, Klothilda, Vadhi, Raga, Daniels, Veerle W, Montero, Joan, Taing, Len, Meyer, Clifford A, Gilan, Omer, Bell, Charles C, Korthauer, Keegan D, Giambartolomei, Claudia, Pasaniuc, Bogdan, Seo, Ji-Heui, Freedman, Matthew L, Ma, Cynthia, Ellis, Matthew J, Krop, Ian, Winer, Eric, Letai, Anthony, Brown, Myles, Dawson, Mark A, Long, Henry W, Zhao, Jean J, Goel, Shom
Published in Nature cancer (01.01.2021)
Published in Nature cancer (01.01.2021)
Get more information
Journal Article
Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation
Evans, Gloria E., Ph.D, Martínez-Conejero, José A., Ph.D, Phillipson, Gregory T.M., M.B., Ch.B, Simón, Carlos, M.D., Ph.D, McNoe, Les A., M.Sc, Sykes, Peter H., M.B., Ch.B, Horcajadas, José A., Ph.D, Lam, Enid Y.N., Ph.D, Print, Cristin G., Ph.D, Sin, Iris L., Ph.D, Evans, John J., Ph.D
Published in Fertility and sterility (01.06.2012)
Published in Fertility and sterility (01.06.2012)
Get full text
Journal Article
PPARγ is essential for protection against nonalcoholic steatohepatitis
Wu, C W, Chu, E S H, Lam, C N Y, Cheng, A S L, Lee, C W, Wong, V W S, Sung, J J Y, Yu, J
Published in Gene therapy (01.06.2010)
Published in Gene therapy (01.06.2010)
Get full text
Journal Article
The Prostate Health Index in predicting initial prostate biopsy outcomes in Asian men with prostate-specific antigen levels of 4–10 ng/mL
Ng, C. F., Chiu, Peter K. F., Lam, N. Y., Lam, H. C., Lee, Kim W. M., Hou, Simon S. M.
Published in International urology and nephrology (01.04.2014)
Published in International urology and nephrology (01.04.2014)
Get full text
Journal Article
An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
Burr, Marian L., Sparbier, Christina E., Chan, Kah Lok, Chan, Yih-Chih, Kersbergen, Ariena, Lam, Enid Y.N., Azidis-Yates, Elizabeth, Vassiliadis, Dane, Bell, Charles C., Gilan, Omer, Jackson, Susan, Tan, Lavinia, Wong, Stephen Q., Hollizeck, Sebastian, Michalak, Ewa M., Siddle, Hannah V., McCabe, Michael T., Prinjha, Rab K., Guerra, Glen R., Solomon, Benjamin J., Sandhu, Shahneen, Dawson, Sarah-Jane, Beavis, Paul A., Tothill, Richard W., Cullinane, Carleen, Lehner, Paul J., Sutherland, Kate D., Dawson, Mark A.
Published in Cancer cell (14.10.2019)
Published in Cancer cell (14.10.2019)
Get full text
Journal Article
BET inhibitor resistance emerges from leukaemia stem cells
Fong, Chun Yew, Gilan, Omer, Lam, Enid Y. N., Rubin, Alan F., Ftouni, Sarah, Tyler, Dean, Stanley, Kym, Sinha, Devbarna, Yeh, Paul, Morison, Jessica, Giotopoulos, George, Lugo, Dave, Jeffrey, Philip, Lee, Stanley Chun-Wei, Carpenter, Christopher, Gregory, Richard, Ramsay, Robert G., Lane, Steven W., Abdel-Wahab, Omar, Kouzarides, Tony, Johnstone, Ricky W., Dawson, Sarah-Jane, Huntly, Brian J. P., Prinjha, Rab K., Papenfuss, Anthony T., Dawson, Mark A.
Published in Nature (London) (24.09.2015)
Published in Nature (London) (24.09.2015)
Get full text
Journal Article
Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis
Savitski, Mikhail M., Zinn, Nico, Faelth-Savitski, Maria, Poeckel, Daniel, Gade, Stephan, Becher, Isabelle, Muelbaier, Marcel, Wagner, Anne J., Strohmer, Katrin, Werner, Thilo, Melchert, Stephanie, Petretich, Massimo, Rutkowska, Anna, Vappiani, Johanna, Franken, Holger, Steidel, Michael, Sweetman, Gavain M., Gilan, Omer, Lam, Enid Y.N., Dawson, Mark A., Prinjha, Rab K., Grandi, Paola, Bergamini, Giovanna, Bantscheff, Marcus
Published in Cell (22.03.2018)
Published in Cell (22.03.2018)
Get full text
Journal Article
Spatio-temporal changes of marine macrobenthic community in sub-tropical waters upon recovery from eutrophication. II. Life-history traits and feeding guilds of polychaete community
Cheung, S.G., Lam, N.W.Y., Wu, R.S.S., Shin, P.K.S.
Published in Marine pollution bulletin (01.02.2008)
Published in Marine pollution bulletin (01.02.2008)
Get full text
Journal Article
Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma
Agarwal, Rishu, Chan, Yih-Chih, Tam, Constantine S., Hunter, Tane, Vassiliadis, Dane, Teh, Charis E., Thijssen, Rachel, Yeh, Paul, Wong, Stephen Q., Ftouni, Sarah, Lam, Enid Y. N., Anderson, Mary Ann, Pott, Christiane, Gilan, Omer, Bell, Charles C., Knezevic, Kathy, Blombery, Piers, Rayeroux, Kathleen, Zordan, Adrian, Li, Jason, Huang, David C. S., Wall, Meaghan, Seymour, John F., Gray, Daniel H. D., Roberts, Andrew W., Dawson, Mark A., Dawson, Sarah-Jane
Published in Nature medicine (01.01.2019)
Published in Nature medicine (01.01.2019)
Get full text
Journal Article
Spatio-temporal changes of marine macrobenthic community in sub-tropical waters upon recovery from eutrophication. I. Sediment quality and community structure
Shin, P.K.S., Lam, N.W.Y., Wu, R.S.S., Qian, P.Y., Cheung, S.G.
Published in Marine pollution bulletin (01.02.2008)
Published in Marine pollution bulletin (01.02.2008)
Get full text
Journal Article