Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of anaplastic lymphoma kinase and c-Ros oncogene 1
Yamazaki, Shinji, Lam, Justine L, Zou, Helen Y, Wang, Hui, Smeal, Tod, Vicini, Paolo
Published in The Journal of pharmacology and experimental therapeutics (01.10.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2014)
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Journal Article
Mechanistic understanding of translational pharmacokinetic-pharmacodynamic relationships in nonclinical tumor models: a case study of orally available novel inhibitors of anaplastic lymphoma kinase
Yamazaki, Shinji, Lam, Justine L, Zou, Helen Y, Wang, Hui, Smeal, Tod, Vicini, Paolo
Published in Drug metabolism and disposition (01.01.2015)
Published in Drug metabolism and disposition (01.01.2015)
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Journal Article
Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin
Varma, Manthena V S, Lin, Jian, Bi, Yi-An, Rotter, Charles J, Fahmi, Odette A, Lam, Justine L, El-Kattan, Ayman F, Goosen, Theunis C, Lai, Yurong
Published in Drug metabolism and disposition (01.05.2013)
Published in Drug metabolism and disposition (01.05.2013)
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Journal Article
IN VITRO AND IN VIVO CORRELATION OF HEPATIC TRANSPORTER EFFECTS ON ERYTHROMYCIN METABOLISM: CHARACTERIZING THE IMPORTANCE OF TRANSPORTER-ENZYME INTERPLAY
Lam, Justine L, Okochi, Hideaki, Huang, Yong, Benet, Leslie Z
Published in Drug metabolism and disposition (01.08.2006)
Published in Drug metabolism and disposition (01.08.2006)
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Journal Article
Elucidating the Effect of Final-Day Dosing of Rifampin in Induction Studies on Hepatic Drug Disposition and Metabolism
Lam, Justine L, Shugarts, Sarah B, Okochi, Hideaki, Benet, Leslie Z
Published in The Journal of pharmacology and experimental therapeutics (01.11.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2006)
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Journal Article
Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
Johnson, Ted W., Richardson, Paul F., Bailey, Simon, Brooun, Alexei, Burke, Benjamin J., Collins, Michael R., Cui, J. Jean, Deal, Judith G., Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D., He, Mingying, Hoffman, Jacqui, Hoffman, Robert L., Huang, Qinhua, Kania, Robert S., Kath, John C., Lam, Hieu, Lam, Justine L., Le, Phuong T., Lingardo, Laura, Liu, Wei, McTigue, Michele, Palmer, Cynthia L., Sach, Neal W., Smeal, Tod, Smith, Graham L., Stewart, Albert E., Timofeevski, Sergei, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y., Edwards, Martin P.
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Journal Article
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models
Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod
Published in Cancer cell (13.07.2015)
Published in Cancer cell (13.07.2015)
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Journal Article
Metabolism, Excretion, and Pharmacokinetics of Lorlatinib (PF-06463922) and Evaluation of the Impact of Radiolabel Position and Other Factors on Comparability of Data Across 2 ADME Studies
Stypinski, Daria, Fostvedt, Luke, Lam, Justine L, Vaz, Alfin, Johnson, Theodore R, Boerma, Jan S, Pithavala, Yazdi K
Published in Journal of clinical pharmacology (01.09.2020)
Published in Journal of clinical pharmacology (01.09.2020)
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Journal Article
Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction
Yanochko, Gina M, Vitsky, Allison, Heyen, Jonathan R, Hirakawa, Brad, Lam, Justine L, May, Jeff, Nichols, Tim, Sace, Frederick, Trajkovic, Dusko, Blasi, Eileen
Published in Toxicological sciences (01.10.2013)
Published in Toxicological sciences (01.10.2013)
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Journal Article
Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier
Rohner, Allison, Spilker, Mary E, Lam, Justine L, Pascual, Bernadette, Bartkowski, Darian, Li, Qing John, Yang, Amy H, Stevens, Greg, Xu, Meirong, Wells, Peter A, Planken, Simon, Nair, Sajiv, Sun, Shaoxian
Published in Molecular cancer therapeutics (01.01.2012)
Published in Molecular cancer therapeutics (01.01.2012)
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Journal Article
Abstract 130: PF-06463922, a novel next generation ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models
Friboulet, Luc, Zou, Helen, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Mahmood, Sidra, Lifshits, Eugene, Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
PF-06463922, an ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models
Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K, Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod
Published in Cancer cell (02.07.2015)
Published in Cancer cell (02.07.2015)
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Journal Article
Abstract PR10: Is CNS availability for oncology a no-brainer? Discovery of PF-06463922, a novel small molecule inhibitor of ALK/ROS1 with preclinical brain availability and broad spectrum potency against ALK-resistant mutations
Johnson, Ted W., Bailey, Simon, Burke, Benjamin J., Collins, Michael R., Cui, J. Jean, Deal, Judy, Deng, Ya-Li, Edwards, Martin P., He, Mingying, Hoffman, Jacqui, Hoffman, Robert L., Huang, Qinhua, Kania, Robert S., Le, Phuong, McTigue, Michele, Palmer, Cynthia L., Richardson, Paul F., Sach, Neal W., Smith, Graham L., Engstrom, Lars, Hu, Wenyue, Lam, Hieu, Lam, Justine L., Smeal, Tod, Zou, Helen Y.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
Discovery of (10R)‑7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H‑8,4-(metheno)pyrazolo[4,3‑h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
Johnson, Ted W, Richardson, Paul F, Bailey, Simon, Brooun, Alexei, Burke, Benjamin J, Collins, Michael R, Cui, J. Jean, Deal, Judith G, Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D, He, Mingying, Hoffman, Jacqui, Hoffman, Robert L, Huang, Qinhua, Kania, Robert S, Kath, John C, Lam, Hieu, Lam, Justine L, Le, Phuong T, Lingardo, Laura, Liu, Wei, McTigue, Michele, Palmer, Cynthia L, Sach, Neal W, Smeal, Tod, Smith, Graham L, Stewart, Albert E, Timofeevski, Sergei, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y, Edwards, Martin P
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Journal Article
Discovery and Pharmacokinetic–Pharmacodynamic Evaluation of an Orally Available Novel Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase and c‐Ros Oncogene 1
Yamazaki, Shinji, Lam, Justine L, Johnson, Ted W
Published in Practical Medicinal Chemistry with Macrocycles (18.08.2017)
Published in Practical Medicinal Chemistry with Macrocycles (18.08.2017)
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