CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models
Anil, Tharappel M, Harish, Chandrashekaran, Lakshmi, Mudigere N, Harsha, Krishnareddy, Onkaramurthy, Mallappa, Sathish Kumar, Venkatesh, Shree, Nitya, Geetha, Venkatachalaiah, Balamurali, Gundalmandikal V, Gopala, Aralakuppe S, Madhusudhan Reddy, Bobbili, Govind, Madabosse K, Anup, Mammen O, Moolemath, Yoganand, Venkataranganna, Marikunte V, Jagannath, Madanahalli R, Somesh, Baggavalli P
Published in Cardiovascular diabetology (25.01.2014)
Published in Cardiovascular diabetology (25.01.2014)
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Journal Article
Inhibition of neutral sphingomyelinases in skeletal muscle attenuates fatty-acid induced defects in metabolism and stress
Verma, Mahesh Kumar, Yateesh, Aggunda Nagaraju, Neelima, Korrapati, Pawar, Niketa, Sandhya, Kandoor, Poornima, Jayaram, Lakshmi, Mudigere N, Yogeshwari, Sivakumaran, Pallavi, Puttrevana M, Oommen, Anup M, Somesh, Baggavalli P, Jagannath, Madanahalli R
Published in SpringerPlus (20.05.2014)
Published in SpringerPlus (20.05.2014)
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Journal Article
Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats
Gowda, Nagesh, Dandu, Anilkumar, Singh, Jaideep, Biswas, Sanghamitra, Raghav, Vijaya, Lakshmi, Mudigere N, Shilpa, Pavagada C, Sunil, Venkategowda, Reddy, Ashokkumar, Sadasivuni, Manojkumar, Aparna, Kumaraswamy, Verma, Mahesh Kumar, Moolemath, Yoganand, Anup, Mammen O, Venkataranganna, Marikunte V, Somesh, Baggavalli P, Jagannath, Madanahalli R
Published in BMC pharmacology & toxicology (21.05.2013)
Published in BMC pharmacology & toxicology (21.05.2013)
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Journal Article
CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models
Sadasivuni, Manoj Kumar, Reddy, Bobbili Madhusudhan, Singh, Jaideep, Anup, Mammen O, Sunil, Venkategowda, Lakshmi, Mudigere N, Yogeshwari, Sivakumaran, Chacko, Suni K, Pooja, Talanki Lokesh, Dandu, Anilkumar, Harish, Chandrashekaran, Gopala, Aralakuppe S, Pratibha, Shivakumar, Naveenkumar, Baisani S, Pallavi, Puttrevana M, Verma, Mahesh Kumar, Moolemath, Yoganand, Somesh, Baggavalli P, Venkataranganna, Marikunte V, Jagannath, Madanahalli R
Published in Diabetology and metabolic syndrome (12.08.2014)
Published in Diabetology and metabolic syndrome (12.08.2014)
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Journal Article
A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits
Anil, Tharappel M, Dandu, Anilkumar, Harsha, KrishnaReddy, Singh, Jaideep, Shree, Nitya, Kumar, Venkatesh Satish, Lakshmi, Mudigere N, Sunil, Venkategowda, Harish, Chandrashekaran, Balamurali, Gundalmandikal V, Naveen Kumar, Baisani S, Gopala, Aralakuppe S, Pratibha, Shivakumar, Sadasivuni, ManojKumar, Anup, Mammen O, Moolemath, Yoganand, Venkataranganna, Marikunte V, Jagannath, Madanahalli R, Somesh, Baggavalli P
Published in BMC pharmacology & toxicology (07.08.2014)
Published in BMC pharmacology & toxicology (07.08.2014)
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Journal Article
A novel 11[beta]-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits
Anil, Tharappel M, Dandu, Anilkumar, Harsha, KrishnaReddy, Singh, Jaideep, Shree, Nitya, Kumar, Venkatesh Satish, Lakshmi, Mudigere N, Sunil, Venkategowda, Harish, Chandrashekaran, Balamurali, Gundalmandikal V, Naveen Kumar, Baisani S, Gopala, Aralakuppe S, Pratibha, Shivakumar, Sadasivuni, ManojKumar, Anup, Mammen O, Moolemath, Yoganand, Venkataranganna, Marikunte V, Jagannath, Madanahalli R, Somesh, Baggavalli P
Published in BMC pharmacology & toxicology (07.08.2014)
Published in BMC pharmacology & toxicology (07.08.2014)
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Journal Article