Toward Therapy of Human Prion Diseases
Aguzzi, Adriano, Lakkaraju, Asvin K.K, Frontzek, Karl
Published in Annual review of pharmacology and toxicology (06.01.2018)
Published in Annual review of pharmacology and toxicology (06.01.2018)
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Journal Article
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6
Küffer, Alexander, Lakkaraju, Asvin K. K., Mogha, Amit, Petersen, Sarah C., Airich, Kristina, Doucerain, Cédric, Marpakwar, Rajlakshmi, Bakirci, Pamela, Senatore, Assunta, Monnard, Arnaud, Schiavi, Carmen, Nuvolone, Mario, Grosshans, Bianka, Hornemann, Simone, Bassilana, Frederic, Monk, Kelly R., Aguzzi, Adriano
Published in Nature (London) (25.08.2016)
Published in Nature (London) (25.08.2016)
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Journal Article
Glial activation in prion diseases is selectively triggered by neuronal PrPSc
Lakkaraju, Asvin K. K., Sorce, Silvia, Senatore, Assunta, Nuvolone, Mario, Guo, Jingjing, Schwarz, Petra, Moos, Rita, Pelczar, Pawel, Aguzzi, Adriano
Published in Brain pathology (Zurich, Switzerland) (01.09.2022)
Published in Brain pathology (Zurich, Switzerland) (01.09.2022)
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Journal Article
Soluble dimeric prion protein ligand activates Adgrg6 receptor but does not rescue early signs of demyelination in PrP-deficient mice
Henzi, Anna, Senatore, Assunta, Lakkaraju, Asvin K K, Scheckel, Claudia, Mühle, Jonas, Reimann, Regina, Sorce, Silvia, Schertler, Gebhard, Toyka, Klaus V, Aguzzi, Adriano
Published in PloS one (12.11.2020)
Published in PloS one (12.11.2020)
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Journal Article
Loss of PIKfyve drives the spongiform degeneration in prion diseases
Lakkaraju, Asvin K K, Frontzek, Karl, Lemes, Emina, Herrmann, Uli, Losa, Marco, Marpakwar, Rajlakshmi, Aguzzi, Adriano
Published in EMBO molecular medicine (07.09.2021)
Published in EMBO molecular medicine (07.09.2021)
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Journal Article
GPR56/ADGRG1 regulates development and maintenance of peripheral myelin
Ackerman, Sarah D, Luo, Rong, Poitelon, Yannick, Mogha, Amit, Harty, Breanne L, D'Rozario, Mitchell, Sanchez, Nicholas E, Lakkaraju, Asvin K K, Gamble, Paul, Li, Jun, Qu, Jun, MacEwan, Matthew R, Ray, Wilson Zachary, Aguzzi, Adriano, Feltri, M Laura, Piao, Xianhua, Monk, Kelly R
Published in The Journal of experimental medicine (05.03.2018)
Published in The Journal of experimental medicine (05.03.2018)
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Journal Article
Palmitoylated calnexin is a key component of the ribosome-translocon complex
Lakkaraju, Asvin KK, Abrami, Laurence, Lemmin, Thomas, Blaskovic, Sanja, Kunz, Béatrice, Kihara, Akio, Dal Peraro, Matteo, van der Goot, Françoise Gisou
Published in The EMBO journal (04.04.2012)
Published in The EMBO journal (04.04.2012)
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Journal Article
Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation
Lakkaraju, Asvin K K, Thankappan, Ratheeshkumar, Mary, Camille, Garrison, Jennifer L, Taunton, Jack, Strub, Katharina
Published in Molecular biology of the cell (15.07.2012)
Published in Molecular biology of the cell (15.07.2012)
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Journal Article
Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity
Goniotaki, Despoina, Lakkaraju, Asvin K K, Shrivastava, Amulya N, Bakirci, Pamela, Sorce, Silvia, Senatore, Assunta, Marpakwar, Rajlakshmi, Hornemann, Simone, Gasparini, Fabrizio, Triller, Antoine, Aguzzi, Adriano
Published in PLoS pathogens (01.11.2017)
Published in PLoS pathogens (01.11.2017)
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Journal Article
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation
Avar, Merve, Heinzer, Daniel, Thackray, Alana M, Liu, Yingjun, Hruska‐Plochan, Marian, Sellitto, Stefano, Schaper, Elke, Pease, Daniel P, Yin, Jiang‐An, Lakkaraju, Asvin KK, Emmenegger, Marc, Losa, Marco, Chincisan, Andra, Hornemann, Simone, Polymenidou, Magdalini, Bujdoso, Raymond, Aguzzi, Adriano
Published in The EMBO journal (01.12.2022)
Published in The EMBO journal (01.12.2022)
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Journal Article
SRP Keeps Polypeptides Translocation-Competent by Slowing Translation to Match Limiting ER-Targeting Sites
Lakkaraju, Asvin K.K., Mary, Camille, Scherrer, Anne, Johnson, Arthur E., Strub, Katharina
Published in Cell (02.05.2008)
Published in Cell (02.05.2008)
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Journal Article
Glial activation in prion diseases is selectively triggered by neuronal PrP Sc
Lakkaraju, Asvin K K, Sorce, Silvia, Senatore, Assunta, Nuvolone, Mario, Guo, Jingjing, Schwarz, Petra, Moos, Rita, Pelczar, Pawel, Aguzzi, Adriano
Published in Brain pathology (Zurich, Switzerland) (01.09.2022)
Published in Brain pathology (Zurich, Switzerland) (01.09.2022)
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Journal Article
Calreticulin mutations affect its chaperone function and perturb the glycoproteome
Schürch, Patrick M, Malinovska, Liliana, Hleihil, Mohammad, Losa, Marco, Hofstetter, Mara C, Wildschut, Mattheus H E, Lysenko, Veronika, Lakkaraju, Asvin K K, Maat, Christina A, Benke, Dietmar, Aguzzi, Adriano, Wollscheid, Bernd, Picotti, Paola, Theocharides, Alexandre P A
Published in Cell reports (Cambridge) (22.11.2022)
Published in Cell reports (Cambridge) (22.11.2022)
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Journal Article
Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency
Theocharides, Alexandre P.A., Lundberg, Pontus, Lakkaraju, Asvin K.K., Lysenko, Veronika, Myburgh, Renier, Aguzzi, Adriano, Skoda, Radek C., Manz, Markus G.
Published in Blood (23.06.2016)
Published in Blood (23.06.2016)
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Journal Article
Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP
Dametto, Paolo, Lakkaraju, Asvin K K, Bridel, Claire, Villiger, Lukas, O'Connor, Tracy, Herrmann, Uli S, Pelczar, Pawel, Rülicke, Thomas, McHugh, Donal, Adili, Arlind, Aguzzi, Adriano
Published in PloS one (06.02.2015)
Published in PloS one (06.02.2015)
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Journal Article
Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein
Mary, Camille, Scherrer, Anne, Huck, Laurent, Lakkaraju, Asvin K K, Thomas, Yves, Johnson, Arthur E, Strub, Katharina
Published in RNA (Cambridge) (01.05.2010)
Published in RNA (Cambridge) (01.05.2010)
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Journal Article
Characterization of APOBEC3G binding to 7SL RNA
Bach, Daniel, Peddi, Shyam, Mangeat, Bastien, Lakkaraju, Asvin, Strub, Katharina, Trono, Didier
Published in Retrovirology (02.07.2008)
Published in Retrovirology (02.07.2008)
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Journal Article
Inefficient targeting to the endoplasmic reticulum by the signal recognition particle elicits selective defects in post-ER membrane trafficking
Lakkaraju, Asvin K.K., Luyet, Pierre-Philippe, Parone, Philippe, Falguières, Thomas, Strub, Katharina
Published in Experimental cell research (15.02.2007)
Published in Experimental cell research (15.02.2007)
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Journal Article