Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation
Przybyla, Laralynne, Lakins, Johnathon N., Weaver, Valerie M.
Published in Cell stem cell (06.10.2016)
Published in Cell stem cell (06.10.2016)
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Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells
Muncie, Jonathon M., Ayad, Nadia M.E., Lakins, Johnathon N., Xue, Xufeng, Fu, Jianping, Weaver, Valerie M.
Published in Developmental cell (21.12.2020)
Published in Developmental cell (21.12.2020)
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Journal Article
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression
Maller, Ori, Drain, Allison P., Barrett, Alexander S., Borgquist, Signe, Ruffell, Brian, Zakharevich, Igor, Pham, Thanh T., Gruosso, Tina, Kuasne, Hellen, Lakins, Johnathon N., Acerbi, Irene, Barnes, J. Matthew, Nemkov, Travis, Chauhan, Aastha, Gruenberg, Jessica, Nasir, Aqsa, Bjarnadottir, Olof, Werb, Zena, Kabos, Peter, Chen, Yunn-Yi, Hwang, E. Shelley, Park, Morag, Coussens, Lisa M., Nelson, Andrew C., Hansen, Kirk C., Weaver, Valerie M.
Published in Nature materials (01.04.2021)
Published in Nature materials (01.04.2021)
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Journal Article
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, Kandice R., Yu, Hongmei, Kass, Laura, Lakins, Johnathon N., Egeblad, Mikala, Erler, Janine T., Fong, Sheri F.T., Csiszar, Katalin, Giaccia, Amato, Weninger, Wolfgang, Yamauchi, Mitsuo, Gasser, David L., Weaver, Valerie M.
Published in Cell (25.11.2009)
Published in Cell (25.11.2009)
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A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer
Stashko, Connor, Hayward, Mary-Kate, Northey, Jason J., Pearson, Neil, Ironside, Alastair J., Lakins, Johnathon N., Oria, Roger, Goyette, Marie-Anne, Mayo, Lakyn, Russnes, Hege G., Hwang, E. Shelley, Kutys, Matthew L., Polyak, Kornelia, Weaver, Valerie M.
Published in Nature communications (15.06.2023)
Published in Nature communications (15.06.2023)
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Journal Article
β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
Weaver, Valerie M, Lelièvre, Sophie, Lakins, Johnathon N, Chrenek, Micah A, Jones, Jonathan C.R, Giancotti, Filippo, Werb, Zena, Bissell, Mina J
Published in Cancer cell (01.09.2002)
Published in Cancer cell (01.09.2002)
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Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels
Lakins, Johnathon N, Chin, Andrew R, Weaver, Valerie M
Published in Methods in molecular biology (Clifton, N.J.) (2012)
Published in Methods in molecular biology (Clifton, N.J.) (2012)
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Controlled modelling of human epiblast and amnion development using stem cells
Zheng, Yi, Xue, Xufeng, Shao, Yue, Wang, Sicong, Esfahani, Sajedeh Nasr, Li, Zida, Muncie, Jonathon M., Lakins, Johnathon N., Weaver, Valerie M., Gumucio, Deborah L., Fu, Jianping
Published in Nature (London) (01.09.2019)
Published in Nature (London) (01.09.2019)
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Journal Article
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
Laklai, Hanane, Miroshnikova, Yekaterina A, Pickup, Michael W, Collisson, Eric A, Kim, Grace E, Barrett, Alex S, Hill, Ryan C, Lakins, Johnathon N, Schlaepfer, David D, Mouw, Janna K, LeBleu, Valerie S, Roy, Nilotpal, Novitskiy, Sergey V, Johansen, Julia S, Poli, Valeria, Kalluri, Raghu, Iacobuzio-Donahue, Christine A, Wood, Laura D, Hebrok, Matthias, Hansen, Kirk, Moses, Harold L, Weaver, Valerie M
Published in Nature medicine (01.05.2016)
Published in Nature medicine (01.05.2016)
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Journal Article
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression
Mouw, Janna K, Yui, Yoshihiro, Damiano, Laura, Bainer, Russell O, Lakins, Johnathon N, Acerbi, Irene, Ou, Guanqing, Wijekoon, Amanda C, Levental, Kandice R, Gilbert, Penney M, Hwang, E Shelley, Chen, Yunn-Yi, Weaver, Valerie M
Published in Nature medicine (01.04.2014)
Published in Nature medicine (01.04.2014)
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Journal Article
Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini
Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M
Published in Journal of cell science (15.10.2023)
Published in Journal of cell science (15.10.2023)
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Journal Article
Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer
Drain, Allison P, Zahir, Nastaran, Northey, Jason J, Zhang, Hui, Huang, Po-Jui, Maller, Ori, Lakins, Johnathon N, Yu, Xinmiao, Leight, Jennifer L, Alston-Mills, Brenda P, Hwang, E Shelley, Chen, Yunn-Yi, Park, Catherine C, Weaver, Valerie M
Published in The Journal of experimental medicine (03.05.2021)
Published in The Journal of experimental medicine (03.05.2021)
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Journal Article
Tensional homeostasis and the malignant phenotype
Paszek, Matthew J., Zahir, Nastaran, Johnson, Kandice R., Lakins, Johnathon N., Rozenberg, Gabriela I., Gefen, Amit, Reinhart-King, Cynthia A., Margulies, Susan S., Dembo, Micah, Boettiger, David, Hammer, Daniel A., Weaver, Valerie M.
Published in Cancer cell (01.09.2005)
Published in Cancer cell (01.09.2005)
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Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
Laklai, Hanane, Miroshnikova, Yekaterina A., Pickup, Michael W., Collisson, Eric A., Kim, Grace E., Barrett, Alex S., Hill, Ryan C., Lakins, Johnathon N., Schlaepfer, David D., Mouw, Janna K., LeBleu, Valerie S., Roy, Nilotpal, Novitskiy, Sergey V., Johansen, Julia S., Poli, Valeria, Kalluri, Raghu, Iacobuzio-Donahue, Christine A., Wood, Laura D., Hebrok, Matthias, Hansen, Kirk, Moses, Harold L., Weaver, Valerie M.
Published in Nature medicine (01.03.2024)
Published in Nature medicine (01.03.2024)
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Journal Article
Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
Muncie, Jonathon M, Falcón-Banchs, Roberto, Lakins, Johnathon N, Sohn, Lydia L, Weaver, Valerie M
Published in Journal of visualized experiments (28.09.2019)
Published in Journal of visualized experiments (28.09.2019)
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Journal Article
alpha 6 beta 4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF- Kappa B-dependent resistance to apoptosis in 3D mammary acini
Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M
Published in Journal of cell science (15.10.2007)
Published in Journal of cell science (15.10.2007)
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Journal Article
α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini
Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M
Published in Journal of cell science (15.10.2007)
Published in Journal of cell science (15.10.2007)
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Journal Article
HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype
Gilbert, Penney M, Mouw, Janna K, Unger, Meredith A, Lakins, Johnathon N, Gbegnon, Mawuse K, Clemmer, Virginia B, Benezra, Miriam, Licht, Jonathan D, Boudreau, Nancy J, Tsai, Kelvin K C, Welm, Alana L, Feldman, Michael D, Weber, Barbara L, Weaver, Valerie M
Published in The Journal of clinical investigation (01.05.2010)
Published in The Journal of clinical investigation (01.05.2010)
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Journal Article
Evidence That Clusterin Has Discrete Chaperone and Ligand Binding Sites
Lakins, Johnathon N, Poon, Stephen, Easterbrook-Smith, Simon B, Carver, John A, Tenniswood, Martin P. R, Wilson, Mark R
Published in Biochemistry (Easton) (08.01.2002)
Published in Biochemistry (Easton) (08.01.2002)
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