Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states
Lake, Eric W., Muretta, Joseph M., Thompson, Andrew R., Rasmussen, Damien M., Majumdar, Abir, Faber, Erik B., Ruff, Emily F., Thomas, David D., Levinson, Nicholas M.
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2018)
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Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography
Ubah, Obinna C., Lake, Eric W., Gunaratne, Gihan S., Gallant, Joseph P., Fernie, Marie, Robertson, Austin J., Marchant, Jonathan S., Bold, Tyler D., Langlois, Ryan A., Matchett, William E., Thiede, Joshua M., Shi, Ke, Yin, Lulu, Moeller, Nicholas H., Banerjee, Surajit, Ferguson, Laura, Kovaleva, Marina, Porter, Andrew J., Aihara, Hideki, LeBeau, Aaron M., Barelle, Caroline J.
Published in Nature communications (16.12.2021)
Published in Nature communications (16.12.2021)
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Journal Article
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation
Ruff, Emily F, Muretta, Joseph M, Thompson, Andrew R, Lake, Eric W, Cyphers, Soreen, Albanese, Steven K, Hanson, Sonya M, Behr, Julie M, Thomas, David D, Chodera, John D, Levinson, Nicholas M
Published in eLife (21.02.2018)
Published in eLife (21.02.2018)
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Identification and biophysical characterization of a novel domain-swapped camelid antibody specific for fentanyl
Gallant, Joseph P., Hicks, Dustin, Shi, Ke, Moeller, Nicholas H., Hoppe, Brooke, Lake, Eric W., Baehr, Carly, Pravetoni, Marco, Aihara, Hideki, LeBeau, Aaron M.
Published in The Journal of biological chemistry (01.08.2024)
Published in The Journal of biological chemistry (01.08.2024)
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Development of an Engineered Single-Domain Antibody for Targeting MET in Non-Small Cell Lung Cancer
Luo, Natalie Y., Minne, Rachel L., Gallant, Joseph P., Gunaratne, Gihan S., West, Jayden L., Javeri, Saahil, Robertson, Austin J., Lake, Eric W., Engle, Jonathan W., Mixdorf, Jason C., Aluicio-Sarduy, Eduardo, Nickel, Kwang P., Hernandez, Reinier, Kimple, Randall J., Baschnagel, Andrew M., LeBeau, Aaron M.
Published in Bioconjugate chemistry (20.03.2024)
Published in Bioconjugate chemistry (20.03.2024)
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Journal Article
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation
Ruff, Emily F, Muretta, Joseph M, Thompson, Andrew, Lake, Eric W, Cyphers, Soreen, Albanese, Steven K, Hanson, Sonya M, Behr, Julie M, Thomas, David D, Chodera, John D, Levinson, Nicholas M
Published in bioRxiv (18.10.2017)
Published in bioRxiv (18.10.2017)
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