Design and synthesis of multipotent 3-aminomethylindoles and 7-azaindoles with enhanced protein phosphatase 2A-activating profile and neuroprotection
Lajarín-Cuesta, Rocío, Arribas, Raquel L., Nanclares, Carmen, García-Frutos, Eva M., Gandía, Luis, de los Ríos, Cristóbal
Published in European journal of medicinal chemistry (05.09.2018)
Published in European journal of medicinal chemistry (05.09.2018)
Get full text
Journal Article
Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists
Espadinha, Margarida, Dourado, Jorge, Lajarin‐Cuesta, Rocio, Herrera‐Arozamena, Clara, Gonçalves, Lidia M. D., Rodríguez‐Franco, María Isabel, de los Rios, Cristobal, Santos, Maria M. M.
Published in ChemMedChem (06.04.2017)
Published in ChemMedChem (06.04.2017)
Get full text
Journal Article
In Silico Prediction of the Toxic Potential of Neuroprotective Bifunctional Molecules Based on Chiral N‑Propargyl-1,2-amino Alcohol Derivatives
Ramos, Eva, Lajarín-Cuesta, Rocío, Arribas, Raquel L, García-Frutos, Eva M, González-Lafuente, Laura, Egea, Javier, de los Ríos, Cristóbal, Romero, Alejandro
Published in Chemical research in toxicology (17.05.2021)
Published in Chemical research in toxicology (17.05.2021)
Get full text
Journal Article
Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity
Silva, Daniel, Chioua, Mourad, Samadi, Abdelouahid, Agostinho, Paula, Garção, Pedro, Lajarín-Cuesta, Rocío, de los Ríos, Cristobal, Iriepa, Isabel, Moraleda, Ignacio, Gonzalez-Lafuente, Laura, Mendes, Eduarda, Pérez, Concepción, Rodríguez-Franco, María Isabel, Marco-Contelles, José, Carmo Carreiras, M
Published in ACS chemical neuroscience (17.04.2013)
Published in ACS chemical neuroscience (17.04.2013)
Get full text
Journal Article
Substituent effect of N-benzylated gramine derivatives that prevent the PP2A inhibition and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease
Gonzalez, Dorleta, Arribas, Raquel L., Viejo, Lucia, Lajarin-Cuesta, Rocio, de los Rios, Cristobal
Published in Bioorganic & medicinal chemistry (15.05.2018)
Published in Bioorganic & medicinal chemistry (15.05.2018)
Get full text
Journal Article
Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration
Martínez-Sanz, Francisco J, Lajarín-Cuesta, Rocío, Moreno-Ortega, Ana J, González-Lafuente, Laura, Fernández-Morales, Jose C, López-Arribas, Raquel, Cano-Abad, María F, Ríos, Cristóbal de los
Published in ACS chemical neuroscience (16.09.2015)
Published in ACS chemical neuroscience (16.09.2015)
Get full text
Journal Article
PP2A Ligand ITH12246 Protects against Memory Impairment and Focal Cerebral Ischemia in Mice
Lorrio, Silvia, Romero, Alejandro, González-Lafuente, Laura, Lajarín-Cuesta, Rocío, Martínez-Sanz, Francisco J, Estrada, Martín, Samadi, Abdelouahid, Marco-Contelles, Jose, Rodríguez-Franco, María Isabel, Villarroya, Mercedes, López, Manuela G, de los Ríos, Cristóbal
Published in ACS chemical neuroscience (18.09.2013)
Published in ACS chemical neuroscience (18.09.2013)
Get full text
Journal Article
Substituent effect of N-benzylated gramine derivatives that prevent the PP2A inhibition and dissipate the neuronal Ca 2+ overload, as a multitarget strategy for the treatment of Alzheimer's disease
Gonzalez, Dorleta, Arribas, Raquel L, Viejo, Lucia, Lajarin-Cuesta, Rocio, de Los Rios, Cristobal
Published in Bioorganic & medicinal chemistry (15.05.2018)
Get full text
Published in Bioorganic & medicinal chemistry (15.05.2018)
Journal Article
Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na+/Ca2+ exchanger
Martínez-Sanz, Francisco J., Lajarín-Cuesta, Rocío, González-Lafuente, Laura, Moreno-Ortega, Ana J., Punzón, Eva, Cano-Abad, María F., de los Ríos, Cristóbal
Published in European journal of medicinal chemistry (15.02.2016)
Published in European journal of medicinal chemistry (15.02.2016)
Get full text
Journal Article
Gramine Derivatives Targeting Ca2+ Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases
Lajarín-Cuesta, Rocío, Nanclares, Carmen, Arranz-Tagarro, Juan-Alberto, González-Lafuente, Laura, Arribas, Raquel L, Araujo de Brito, Monique, Gandía, Luis, de los Ríos, Cristóbal
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
Get full text
Journal Article
Gramine Derivatives Targeting Ca(2+) Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases
Lajarín-Cuesta, Rocío, Nanclares, Carmen, Arranz-Tagarro, Juan-Alberto, González-Lafuente, Laura, Arribas, Raquel L, Araujo de Brito, Monique, Gandía, Luis, de Los Ríos, Cristóbal
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
Get full text
Journal Article
Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger
Martínez-Sanz, Francisco J, Lajarín-Cuesta, Rocío, González-Lafuente, Laura, Moreno-Ortega, Ana J, Punzón, Eva, Cano-Abad, María F, de los Ríos, Cristóbal
Published in European journal of medicinal chemistry (15.02.2016)
Published in European journal of medicinal chemistry (15.02.2016)
Get full text
Journal Article
Gramine Derivatives Targeting Ca 2+ Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases
Lajarín-Cuesta, Rocío, Nanclares, Carmen, Arranz-Tagarro, Juan-Alberto, González-Lafuente, Laura, Arribas, Raquel L., Araujo de Brito, Monique, Gandía, Luis, de los Ríos, Cristóbal
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
Get full text
Journal Article
Nuevos derivados de (1H-Indol-3-Ilmetil) Dimetilamina con actividad bloqueador de los canales de Ca2+ dependientes de voltaje, preferentemente NO-L, y su aplicación en el tratamiento de enfermedades del sistema nervioso
LAJARIN CUESTA, Rocío, GANDIA JUAN, Luis, ARRANZ TAGARRO, Juan Alberto, GARCIA GARCIA, Antonio, PEREZ DE NANCLARES, Carmen, DE LOS RIOS SALGADO, Cristóbal
Year of Publication 16.08.2017
Get full text
Year of Publication 16.08.2017
Patent
Derivados de 5-arilpirido [2,3-e][1,4]tiazepinona con actividad bloqueante del intercambiador sodio/calcio mitocondrial
LAJARIN CUESTA, Rocío, MORENO ORTEGA, Ana José, MARTINEZ SANZ, Francisco Javier, CANO ABAD, María Francisca, ARRANZ TAGARRO, Juan Alberto, GARCIA GARCIA, Antonio, DE LOS RIOS SALGADO, Cristóbal
Year of Publication 02.04.2018
Get full text
Year of Publication 02.04.2018
Patent
Nuevos derivados de (1H-Indol-3-Ilmetil) Dimetilamina con actividad bloqueador de los canales de Ca2+ dependientes de voltaje, preferentemente NO-L, y su aplicación en el tratamiento de enfermedades del sistema nervioso
LAJARIN CUESTA, Rocío, DE lOS RIOS SALGADO, Cristóbal, GANDIA JUAN, Luis, ARRANZ TAGARRO, Juan Alberto, GARCIA GARCIA, Antonio, PEREZ DE NANCLARES, Carmen
Year of Publication 15.11.2016
Get full text
Year of Publication 15.11.2016
Patent
Derivados de 5-arilpirido [2,3-e][1,4]tiazepinona con actividad bloqueante del intercambiador sodio/calcio mitocondrial
LAJARIN CUESTA, Rocío, MORENO ORTEGA, Ana José, MARTINEZ SANZ, Francisco Javier, CANO ABAD, María Francisca, ARRANZ TAGARRO, Juan Alberto, GARCIA GARCIA, Antonio, DE LOS RIOS SALGADO, Cristóbal
Year of Publication 15.06.2017
Get full text
Year of Publication 15.06.2017
Patent