Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells
Hosfield, David J, Weber, Sandra, Li, Nan-Sheng, Suavage, Madline, Joiner, Carstyn F, Hancock, Govinda R, Sullivan, Emily A, Nduwke, Estelle, Han, Ross, Cush, Sydney, Lainé, Muriel, Mader, Sylvie C, Greene, Geoffrey L, Fanning, Sean W
Published in eLife (16.05.2022)
Published in eLife (16.05.2022)
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Lasofoxifene as a potential treatment for aromatase inhibitor-resistant ER-positive breast cancer
Lainé, Muriel, Greene, Marianne E, Kurleto, Justyna D, Bozek, Grazyna, Leng, Tiffany, Huggins, Rosemary J, Komm, Barry S, Greene, Geoffrey L
Published in Breast cancer research : BCR (07.06.2024)
Published in Breast cancer research : BCR (07.06.2024)
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Glucocorticoid Receptor Activation in Lobular Breast Cancer Is Associated with Reduced Cell Proliferation and Promotion of Metastases
Porter, Baylee A, Frerich, Candace, Lainé, Muriel, Clark, Abigail B, Durdana, Ishrat, Lee, Jeon, Taya, Manisha, Sahoo, Sunati, Greene, Geoffrey L, Bennett, Lynda, Conzen, Suzanne D
Published in Cancers (22.09.2023)
Published in Cancers (22.09.2023)
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The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L
Published in eLife (29.11.2018)
Published in eLife (29.11.2018)
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Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer
Lainé, Muriel, Fanning, Sean W, Chang, Ya-Fang, Green, Bradley, Greene, Marianne E, Komm, Barry, Kurleto, Justyna D, Phung, Linda, Greene, Geoffrey L
Published in Breast cancer research : BCR (12.05.2021)
Published in Breast cancer research : BCR (12.05.2021)
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Inducible Nitric Oxide Synthase Mediates Prostaglandin H2 Synthase Nitration and Suppresses Eicosanoid Production
Deeb, Ruba S, Shen, Hao, Gamss, Caryn, Gavrilova, Tatyana, Summers, Barbara D, Kraemer, Rosemary, Hao, Gang, Gross, Steven S, Laine, Muriel, Maeda, Nobuyo, Hajjar, David P, Upmacis, Rita K
Published in The American journal of pathology (01.01.2006)
Published in The American journal of pathology (01.01.2006)
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The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer
Cocce, Kimberly J., Jasper, Jeff S., Desautels, Taylor K., Everett, Logan, Wardell, Suzanne, Westerling, Thomas, Baldi, Robert, Wright, Tricia M., Tavares, Kendall, Yllanes, Alex, Bae, Yeeun, Blitzer, Jeremy T., Logsdon, Craig, Rakiec, Daniel P., Ruddy, David A., Jiang, Tiancong, Broadwater, Gloria, Hyslop, Terry, Hall, Allison, Laine, Muriel, Phung, Linda, Greene, Geoffrey L., Martin, Lesley-Ann, Pancholi, Sunil, Dowsett, Mitch, Detre, Simone, Marks, Jeffrey R., Crawford, Gregory E., Brown, Myles, Norris, John D., Chang, Ching-yi, McDonnell, Donald P.
Published in Cell reports (Cambridge) (22.10.2019)
Published in Cell reports (Cambridge) (22.10.2019)
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The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation
Abot, Anne, Fontaine, Coralie, Buscato, Mélissa, Solinhac, Romain, Flouriot, Gilles, Fabre, Aurélie, Drougard, Anne, Rajan, Shyamala, Laine, Muriel, Milon, Alain, Muller, Isabelle, Henrion, Daniel, Adlanmerini, Marine, Valéra, Marie‐Cécile, Gompel, Anne, Gerard, Céline, Péqueux, Christel, Mestdagt, Mélanie, Raymond‐Letron, Isabelle, Knauf, Claude, Ferriere, François, Valet, Philippe, Gourdy, Pierre, Katzenellenbogen, Benita S, Katzenellenbogen, John A, Lenfant, Françoise, Greene, Geoffrey L, Foidart, Jean‐Michel, Arnal, Jean‐François
Published in EMBO molecular medicine (01.10.2014)
Published in EMBO molecular medicine (01.10.2014)
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Dynamic epi‐transcriptomic landscape mapping with disease progression in estrogen receptor‐positive breast cancer
Keelan, Stephen, Ola, Mihaela, Charmsaz, Sara, Cocchiglia, Sinéad, Ottaviani, Daniela, Hickey, Seán, Purcell, Siobhan, Bane, Fiona, Hegarty, Aisling, Doherty, Ben, Sheehan, Katherine, Hudson, Lance, Cosgrove, Nicola, Roux, Benjamin, Laine, Muriel, Greene, Geoffrey, Varešlija, Damir, Hill, Arnold Konrad, Young, Leonie
Published in Cancer communications (London, England) (01.05.2023)
Published in Cancer communications (London, England) (01.05.2023)
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Journal Article
Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite
Deeb, Ruba S., Hao, Gang, Gross, Steven S., Laineé, Muriel, Qiu, Ju Hua, Resnick, Brad, Barbar, Elisar J., Hajjar, David P., Upmacis, Rita K.
Published in Journal of lipid research (01.05.2006)
Published in Journal of lipid research (01.05.2006)
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Journal Article
RAC3 is a promigratory co-activator of ERα
Walker, Matthew P, Zhang, Maomao, Le, Thien P, Wu, Patricia, Lainé, Muriel, Greene, Geoffrey L
Published in Oncogene (10.01.2011)
Published in Oncogene (10.01.2011)
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Abstract P4-02-07: Lasofoxifene as a potential treatment for aromatase inhibitor resistant ER positive breast cancer
Laine, Muriel, Greene, Marianne E, Leng, Tiffany, Kurleto, Justyna D, Li, Sophia, Komm, Barry, Greene, Geoffrey L
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Abstract 4370: Lasofoxifene alone or in combination with palbociclib as an effective treatment for therapy-resistant ER-positive metastatic breast cancer
Laine, Muriel, Kurleto, Justyna D., Greene, Marianne E., Phung, Linda, Komm, Barry S., Greene, Geoffrey L.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Inducible Nitric Oxide Synthase Mediates Prostaglandin H 2 Synthase Nitration and Suppresses Eicosanoid Production
Deeb, Ruba S., Shen, Hao, Gamss, Caryn, Gavrilova, Tatyana, Summers, Barbara D., Kraemer, Rosemary, Hao, Gang, Gross, Steven S., Lainé, Muriel, Maeda, Nobuyo, Hajjar, David P., Upmacis, Rita K.
Published in The American journal of pathology (2006)
Published in The American journal of pathology (2006)
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Journal Article
Abstract 2472: Effective ER antagonists resist conformational restrictions imposed by somatic mutation but do not correlate with effects on receptor stability in live cells
Hosfield, David, Li, Nan-Sheng, Han, Ross, Laine, Muriel, Weber, Sandra, Sauvage, Madaline, Madar, Sylvie, Greene, Geoffrey, Fanning, Sean
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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