Discovery of AMG 853, a CRTH2 and DP Dual Antagonist
Liu, Jiwen, Li, An-Rong, Wang, Yingcai, Johnson, Mike G, Su, Yongli, Shen, Wang, Wang, Xuemei, Lively, Sarah, Brown, Matthew, Lai, SuJen, Gonzalez Lopez De Turiso, Felix, Xu, Qingge, Van Lengerich, Bettina, Schmitt, Mike, Fu, Zice, Sun, Ying, Lawlis, Shanna, Seitz, Lisa, Danao, Jay, Wait, Jill, Ye, Qiuping, Tang, Hua Lucy, Grillo, Mark, Collins, Tassie L, Sullivan, Timothy J, Medina, Julio C
Published in ACS medicinal chemistry letters (12.05.2011)
Published in ACS medicinal chemistry letters (12.05.2011)
Get full text
Journal Article
Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes
Du, Xiaohui, Kim, Yong-Jae, Lai, SuJen, Chen, Xi, Lizarzaburu, Mike, Turcotte, Simon, Fu, Zice, Liu, Qingxiang, Zhang, Ying, Motani, Alykhan, Oda, Kozo, Okuyama, Ryo, Nara, Futoshi, Murakoshi, Michiko, Fu, Angela, Reagan, Jeff D., Fan, Peter, Xiong, Yumei, Shen, Wang, Li, Leping, Houze, Jonathan, Medina, Julio C.
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Get full text
Journal Article
Identification of aminopiperidine benzamides as MCHr1 antagonists
Vasudevan, Anil, Verzal, Mary K., Wodka, Derek, Souers, Andrew J., Blackburn, Christopher, Che, Jennifer Lee, Lai, Sujen, Brodjian, Sevan, Falls, Doug H., Dayton, Brian D., Govek, Elizabeth, Daniels, Tom, Geddes, Brad, Marsh, Kennan C., Hernandez, Lisa E., Collins, Christine A., Kym, Philip R.
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Get full text
Journal Article
Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists
Vasudevan, Anil, LaMarche, Matthew J., Blackburn, Christopher, Che, Jennifer Lee, Luchaco-Cullis, Courtney A., Lai, Sujen, Marsilje, Thomas H., Patane, Michael A., Souers, Andrew J., Wodka, Derek, Geddes, Bradley, Chen, Sumiao, Brodjian, Seven, Falls, Doug H., Dayton, Brian D., Bush, Eugene, Brune, Michael, Shapiro, Robin D., Marsh, Kennan C., Hernandez, Lisa E., Sham, Hing L., Collins, Christine A., Kym, Philip R.
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
Get full text
Journal Article
Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction
Chen, Xiaoqi, Kopecky, David J, Mihalic, Jeff, Jeffries, Shawn, Min, Xiaoshan, Heath, Julie, Deignan, Jeff, Lai, SuJen, Fu, Zice, Guimaraes, Cristiano, Shen, Shanling, Li, Shyun, Johnstone, Sheree, Thibault, Stephen, Xu, Haoda, Cardozo, Mario, Shen, Wang, Walker, Nigel, Kayser, Frank, Wang, Zhulun
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
Get full text
Journal Article
Abstract LB-A20: True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy
Kulkarni, Meghana M, Dwight, Timothy, Marino, Kristen, Allen, Bryce K, Taimi, Mohammed, Bastos, Cecilia, Lai, Sujen, Koh, Cheryl, Samant, Ramya, Tesar, Bethany, Huang, Huang, Chamberlain, Brian, Rice, James M, Tan, Dazhi, Lin, Zhixiong, Shechter, Sharon, Li, Stella, Sparks, Sam, Soutter, Holly, Swann, Steven, Sherman, Woody, Winter, Christopher
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
Get full text
Journal Article
Synthesis of benzimidazoles from 1,1-dibromoethenes
Shen, Wang, Kohn, Todd, Fu, Zice, Jiao, XianYun, Lai, Sujen, Schmitt, Michael
Published in Tetrahedron letters (15.12.2008)
Published in Tetrahedron letters (15.12.2008)
Get full text
Journal Article
PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 14.11.2023
Get full text
Year of Publication 14.11.2023
Patent
5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties
Kohn, Todd J, Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E, Kraser, Christopher F, Hinklin, Ronald J, Boys, Mark L, Medina, Julio C, Houze, Jonathan, Dransfield, Paul, Coward, Peter
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
Get full text
Journal Article
PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 20.06.2022
Get full text
Year of Publication 20.06.2022
Patent
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394
Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
Get full text
Journal Article
PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 08.06.2021
Get full text
Year of Publication 08.06.2021
Patent
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators
Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
Get full text
Journal Article
Aminopyrazole–Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies
Yu, Ming, Lizarzaburu, Mike, Motani, Alykhan, Fu, Zice, Du, Xiaohui, Liu, Jiwen (Jim), Jiao, Xianyun, Lai, SuJen, Fan, Peter, Fu, Angela, Liu, Qingxiang, Murakoshi, Michiko, Nara, Futoshi, Oda, Kozo, Okuyama, Ryo, Reagan, Jeff D, Watanabe, Nobuaki, Yamazaki, Mami, Xiong, Yumei, Zhang, Ying, Zhuang, Run, Lin, Daniel C.-H, Houze, Jonathan B, Medina, Julio C, Li, Leping
Published in ACS medicinal chemistry letters (12.09.2013)
Published in ACS medicinal chemistry letters (12.09.2013)
Get full text
Journal Article
Corrigendum to “Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes” [Bioorg. Med. Chem. Lett. 22 (2012) 6218–6223]
Du, Xiaohui, Kim, Yong-Jae, Lai, SuJen, Chen, Xi, Lizarzaburu, Mike, Turcotte, Simon, Fu, Zice, Liu, Qingxiang, Zhang, Ying, Motani, Alykhan, Oda, Kozo, Okuyama, Ryo, Nara, Futoshi, Murakoshi, Michiko, Fu, Angela, Reagan, Jeff D., Fan, Peter, Xiong, Yumei, Shen, Wang, Li, Leping, Houze, Jonathan, Medina, Julio C.
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Get full text
Journal Article
PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 04.06.2020
Get full text
Year of Publication 04.06.2020
Patent
PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 29.05.2019
Get full text
Year of Publication 29.05.2019
Patent
PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 04.06.2018
Get full text
Year of Publication 04.06.2018
Patent
Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists
Blackburn, Christopher, LaMarche, Matthew J., Brown, James, Che, Jennifer Lee, Cullis, Courtney A., Lai, Sujen, Maguire, Martin, Marsilje, Thomas, Geddes, Bradley, Govek, Elizabeth, Kadambi, Vivek, Doherty, Colleen, Dayton, Brian, Brodjian, Sevan, Marsh, Kennan C., Collins, Christine A., Kym, Philip R.
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
Get full text
Journal Article
Tandem Chain Extension−Aldol Reaction: Syn Selectivity with a Zinc Enolate
Lai, Sujen, Zercher, Charles K, Jasinski, Jerry P, Reid, Seth N, Staples, Richard J
Published in Organic letters (27.12.2001)
Published in Organic letters (27.12.2001)
Get full text
Journal Article