Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
Smith, Ian, Greenside, Peyton G, Natoli, Ted, Lahr, David L, Wadden, David, Tirosh, Itay, Narayan, Rajiv, Root, David E, Golub, Todd R, Subramanian, Aravind, Doench, John G
Published in PLoS biology (30.11.2017)
Published in PLoS biology (30.11.2017)
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High-throughput Phenotyping of Lung Cancer Somatic Mutations
Berger, Alice H., Brooks, Angela N., Wu, Xiaoyun, Shrestha, Yashaswi, Chouinard, Candace, Piccioni, Federica, Bagul, Mukta, Kamburov, Atanas, Imielinski, Marcin, Hogstrom, Larson, Zhu, Cong, Yang, Xiaoping, Pantel, Sasha, Sakai, Ryo, Watson, Jacqueline, Kaplan, Nathan, Campbell, Joshua D., Singh, Shantanu, Root, David E., Narayan, Rajiv, Natoli, Ted, Lahr, David L., Tirosh, Itay, Tamayo, Pablo, Getz, Gad, Wong, Bang, Doench, John, Subramanian, Aravind, Golub, Todd R., Meyerson, Matthew, Boehm, Jesse S.
Published in Cancer cell (08.08.2016)
Published in Cancer cell (08.08.2016)
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Journal Article
The GCTx format and cmap{Py, R, M, J} packages: resources for optimized storage and integrated traversal of annotated dense matrices
Enache, Oana M, Lahr, David L, Natoli, Ted E, Litichevskiy, Lev, Wadden, David, Flynn, Corey, Gould, Joshua, Asiedu, Jacob K, Narayan, Rajiv, Subramanian, Aravind
Published in Bioinformatics (15.04.2019)
Published in Bioinformatics (15.04.2019)
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Journal Article
High-throughput Phenotyping of Lung Cancer Somatic Mutations
Berger, Alice H., Brooks, Angela N., Wu, Xiaoyun, Shrestha, Yashaswi, Chouinard, Candace, Piccioni, Federica, Bagul, Mukta, Kamburov, Atanas, Imielinski, Marcin, Hogstrom, Larson, Zhu, Cong, Yang, Xiaoping, Pantel, Sasha, Sakai, Ryo, Watson, Jacqueline, Kaplan, Nathan, Campbell, Joshua D., Singh, Shantanu, Root, David E., Narayan, Rajiv, Natoli, Ted, Lahr, David L., Tirosh, Itay, Tamayo, Pablo, Getz, Gad, Wong, Bang, Doench, John, Subramanian, Aravind, Golub, Todd R., Meyerson, Matthew, Boehm, Jesse S.
Published in Cancer cell (11.12.2017)
Published in Cancer cell (11.12.2017)
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A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations
Litichevskiy, Lev, Peckner, Ryan, Abelin, Jennifer G., Asiedu, Jacob K., Creech, Amanda L., Davis, John F., Davison, Desiree, Dunning, Caitlin M., Egertson, Jarrett D., Egri, Shawn, Gould, Joshua, Ko, Tak, Johnson, Sarah A., Lahr, David L., Lam, Daniel, Liu, Zihan, Lyons, Nicholas J., Lu, Xiaodong, MacLean, Brendan X., Mungenast, Alison E., Officer, Adam, Natoli, Ted E., Papanastasiou, Malvina, Patel, Jinal, Sharma, Vagisha, Toder, Courtney, Tubelli, Andrew A., Young, Jennie Z., Carr, Steven A., Golub, Todd R., Subramanian, Aravind, MacCoss, Michael J., Tsai, Li-Huei, Jaffe, Jacob D.
Published in Cell systems (25.04.2018)
Published in Cell systems (25.04.2018)
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Journal Article
A Combinatorial Study of Thin-Film Process Variables Using Microhotplates
Lahr, D.L., Hertz, J.L., Semancik, S.
Published in Journal of microelectromechanical systems (01.04.2010)
Published in Journal of microelectromechanical systems (01.04.2010)
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Journal Article
An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries
Mulrooney, Carol A., Lahr, David L., Quintin, Michael J., Youngsaye, Willmen, Moccia, Dennis, Asiedu, Jacob K., Mulligan, Evan L., Akella, Lakshmi B., Marcaurelle, Lisa A., Montgomery, Philip, Bittker, Joshua A., Clemons, Paul A., Brudz, Stephen, Dandapani, Sivaraman, Duvall, Jeremy R., Tolliday, Nicola J., De Souza, Andrea
Published in Journal of computer-aided molecular design (01.05.2013)
Published in Journal of computer-aided molecular design (01.05.2013)
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Journal Article
An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines
de Souza, Andrea, Bittker, Joshua A., Lahr, David L., Brudz, Steve, Chatwin, Simon, Oprea, Tudor I., Waller, Anna, Yang, Jeremy J., Southall, Noel, Guha, Rajarshi, Schürer, Stephan C., Vempati, Uma D., Southern, Mark R., Dawson, Eric S., Clemons, Paul A., Chung, Thomas D.Y.
Published in SLAS discovery (01.06.2014)
Published in SLAS discovery (01.06.2014)
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Fabrication and gas sensing performance of parallel assemblies of metal oxide nanotubes supported by porous aluminum oxide membranes
Artzi-Gerlitz, Reit, Benkstein, Kurt D., Lahr, David L., Hertz, Joshua L., Montgomery, Christopher B., Bonevich, John E., Semancik, Steve, Tarlov, Michael J.
Published in Sensors and actuators. B, Chemical (02.02.2009)
Published in Sensors and actuators. B, Chemical (02.02.2009)
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Journal Article
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Subramanian, Aravind, Narayan, Rajiv, Corsello, Steven M., Peck, David D., Natoli, Ted E., Lu, Xiaodong, Gould, Joshua, Davis, John F., Tubelli, Andrew A., Asiedu, Jacob K., Lahr, David L., Hirschman, Jodi E., Liu, Zihan, Donahue, Melanie, Julian, Bina, Khan, Mariya, Wadden, David, Smith, Ian C., Lam, Daniel, Liberzon, Arthur, Toder, Courtney, Bagul, Mukta, Orzechowski, Marek, Enache, Oana M., Piccioni, Federica, Johnson, Sarah A., Lyons, Nicholas J., Berger, Alice H., Shamji, Alykhan F., Brooks, Angela N., Vrcic, Anita, Flynn, Corey, Rosains, Jacqueline, Takeda, David Y., Hu, Roger, Davison, Desiree, Lamb, Justin, Ardlie, Kristin, Hogstrom, Larson, Greenside, Peyton, Gray, Nathanael S., Clemons, Paul A., Silver, Serena, Wu, Xiaoyun, Zhao, Wen-Ning, Read-Button, Willis, Wu, Xiaohua, Haggarty, Stephen J., Ronco, Lucienne V., Boehm, Jesse S., Schreiber, Stuart L., Doench, John G., Bittker, Joshua A., Root, David E., Wong, Bang, Golub, Todd R.
Published in Cell (30.11.2017)
Published in Cell (30.11.2017)
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An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines
de Souza, Andrea, Bittker, Joshua A, Lahr, David L, Brudz, Steve, Chatwin, Simon, Oprea, Tudor I, Waller, Anna, Yang, Jeremy J, Southall, Noel, Guha, Rajarshi, Schürer, Stephan C, Vempati, Uma D, Southern, Mark R, Dawson, Eric S, Clemons, Paul A, Chung, Thomas D Y
Published in Journal of biomolecular screening (01.06.2014)
Published in Journal of biomolecular screening (01.06.2014)
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Journal Article
Abstract 1224: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers
Centore, Richard C., Soares, Luis M., Vaswani, Rishi G., Ichikawa, Kana, Li, Zhifang, Fan, Hong, Setser, Jeremy, Lahr, David L., Zawadzke, Laura, Chen, Xueying, Barnash, Kimberly D., Muwanguzi, Jordana, Anthony, Neville, Sandoval, Gabriel J., Feldman, Katharine, Adam, Ammar, Huang, David, Schiller, Shawn, Wilson, Kevin, Voigt, Johannes, Hentemann, Martin, Millan, David S., Chan, Ho Man, Bellon, Steven F., Decicco, Carl P., Xu, Lan
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract A013: Leukemic stem cell differentiation visible at single-cell resolution in AML patients treated with BRG1/BRM inhibitor FHD-286
Elliott, GiNell, Wan, Jessica, Horrigan, Kim, Collins, Mike, Thomsen, Astrid, Gartin, Ashley K, Adam, Ammar, Lahr, David L, Sandoval, Gabriel, Agresta, Sameul, Piel, Jessica, Hentemann, Martin
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
888 Synergistic efficacy of the BRM/BRG1 ATPase inhibitor, FHD-286, and anti-PD-1 antibody in mouse syngeneic tumor models
Ichikawa, Kana, Ammar, Adam, Hsin-Jung, Wu, Lahr, David, Xu, Lan, Antonakos, Brandon, Johannessen, Liv, Bellon, Steven, Kruger, Ryan, Centore, Richard, Hentemann, Martin
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article
Abstract A064: Establishing the cellular and molecular impacts of the dual BRM/BRG1 inhibitor FHD-286 on pre-clinical models of non-small cell lung cancer (NSCLC)
Wilson, Molly M., Adam, Ammar, Amaral, Victoria, Mikse, Oliver, Elliott, GiNell, Lahr, David L., Gartin, Ashley K., Wan, Jessica, Johannessen, Liv, Ichikawa, Kana, Feldman, Katharine, Piel, Jessica, Sandoval, Gabriel J., Centore, Richard C., Bellon, Steven F., Hentemann, Martin
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Abstract A053: The dual BRG1/BRM (SMARCA4/2) inhibitor FHD-286 induces functional differentiation and splicing defects in preclinical models of acute myeloid leukemia (AML)
Gartin, Ashley K., Mayhew, David N., Lahr, David L., Elliott, GiNell, Gandevia, Heena, Wilson, Molly M., Centore, Richard, Collins, Mike, Thomsen, Astrid, Piel, Jessica, Sandoval, Gabriel J., Hentemann, Martin
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract A058: Investigating the molecular role of BRD9 in synovial sarcoma
Topal, Salih, Dominici, Claudia, Collins, Michael, Lahr, David L, Zhou, Qianhe, Uzan, Flore, Mayhew, David, Adam, Ammar, Garbitt-Amaral, Victoria, Antonakos, Brandon, Mikse, Oliver, Ahmad, Hafiz, Parikh, Salonee, Lin, Mei Yun, Wu, Hsin-Jung, Sandoval, Gabriel, Soares, Luis M. M., Muwanguzi, Jordana, Chen, Huawei, Yang, Zhaoxia, Lowe, Jason T., Netherton, Matt, Zawadzke, Laura, Voigt, Johannes, Huang, Liyue, Ruppel, Sabine, Chan, Ho Man, Kruger, Ryan, Millan, David S., Innis, Scott, Bellon, Steven F.
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract A049: Investigation of FHD-609, a potent degrader of BRD9, in preclinical models of acute myeloid leukemia (AML)
Dominici, Claudia, Mayhew, David, Adam, Ammar, Uzan, Flore, Garbitt-Amaral, Victoria, Mikse, Oliver, Antonakos, Brandon, Ahmad, Hafiz, Parikh, Salonee, Lin, Mei Yun, Sandoval, Gabriel, Lahr, David, Wu, Hsin-Jung, Xu, Mengni, Brennan, Sean, Soares, Luis M. M., Muwanguzi, Jordana, Chen, Huawei, Yang, Zhaoxia, Lowe, Jason T, Netherton, Matt, Zawadzke, Laura, Voigt, Johannes, Huang, Liyue, Ruppel, Sabine, Chan, Ho Man, Kruger, Ryan, Milan, David S, Innis, Scott, Zhou, Qianhe, Bellon, Steven F
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract LB190: Modulation of SPI1 transcriptional program contributes to the preclinical anti-tumor activity of SMARCA4/SMARCA2 ATPase inhibitors in AML
Sandoval, Gabriel J., Feldman, Katharine, Topal, Sal, Adam, Ammar, Wu, Hsin-Jung, Sappal, Darshan, Soares, Luis M., Lahr, David L., Xu, Lan, Vaswani, Rishi G., Muwanguzi, Jordana, Huang, Liyue, Piel, Jessica, Collins, Mike, Chan, Ho Man, Thomenius, Michael J., Bellon, Steven F., Kruger, Ryan G., Decicco, Carl P., Centore, Richard C., Hentemann, Martin
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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