Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study
WILLETT, Christopher G, DUDA, Dan G, SHELLITO, Paul, CZITO, Brian G, WONG, Terence Z, PAULSON, Erik, POLESKI, Martin, VUJASKOVIC, Zeljko, BENTLEY, Rex, CHEN, Helen X, CLARK, Jeffrey W, JAIN, Rakesh K, DI TOMASO, Emmanuelle, BOUCHER, Yves, ANCUKIEWICZ, Marek, SAHANI, Dushyant V, LAHDENRANTA, Johanna, CHUNG, Daniel C, FISCHMAN, Alan J, LAUWERS, Gregory Y
Published in Journal of clinical oncology (20.06.2009)
Published in Journal of clinical oncology (20.06.2009)
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A Vascular Normalization Index as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients
SORENSEN, A. Gregory, BATCHELOR, Tracy T, DI TOMASO, Emmanuelle, DUDA, Dan G, JAIN, Rakesh K, ZHANG, Wei-Ting, CHEN, Poe-Jou, YEO, Priscilla, MEIYUN WANG, JENNINGS, Dominique, WEN, Patrick Y, LAHDENRANTA, Johanna, ANCUKIEWICZ, Marek
Published in Cancer research (Chicago, Ill.) (01.07.2009)
Published in Cancer research (Chicago, Ill.) (01.07.2009)
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Efficacy, Safety, and Potential Biomarkers of Sunitinib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study
ZHU, Andrew X, SAHANI, Dushyant V, BHARGAVA, Pankaj, MEYERHARDT, Jeffrey, CLARK, Jeffrey W, KWAK, Eunice L, HEZEL, Aram F, MIKSAD, Rebecca, ABRAMS, Thomas A, ENZINGER, Peter C, FUCHS, Charles S, RYAN, David P, DUDA, Dan G, JAIN, Rakesh K, DI TOMASO, Emmanuelle, ANCUKIEWICZ, Marek, CATALANO, Onofrio A, SINDHWANI, Vivek, BLASZKOWSKY, Lawrence S, YOON, Sam S, LAHDENRANTA, Johanna
Published in Journal of clinical oncology (20.06.2009)
Published in Journal of clinical oncology (20.06.2009)
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Journal Article
Edema Control by Cediranib, a Vascular Endothelial Growth Factor Receptor–Targeted Kinase Inhibitor, Prolongs Survival Despite Persistent Brain Tumor Growth in Mice
KAMOUN, Walid S, LEY, Carsten D, FUKUMURA, Dai, SORENSEN, A. Gregory, JAIN, Rakesh K, FARRAR, Christian T, DUYVERMAN, Annique M, LAHDENRANTA, Johanna, LACORRE, Delphine A, BATCHELOR, Tracy T, DI TOMASO, Emmanuelle, DUDA, Dan G, MUNN, Lance L
Published in Journal of clinical oncology (20.05.2009)
Published in Journal of clinical oncology (20.05.2009)
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Journal Article
Endothelial Nitric Oxide Synthase Mediates Lymphangiogenesis and Lymphatic Metastasis
LAHDENRANTA, Johanna, HAGENDOORN, Jeroen, PADERA, Timothy P, HOSHIDA, Tohru, NELSON, Gregory, KASHIWAGI, Satoshi, JAIN, Rakesh K, FUKUMURA, Dai
Published in Cancer research (Chicago, Ill.) (01.04.2009)
Published in Cancer research (Chicago, Ill.) (01.04.2009)
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Journal Article
Anti-Vascular Endothelial Growth Factor Therapies as a Novel Therapeutic Approach to Treating Neurofibromatosis-Related Tumors
HON KIT WONG, LAHDENRANTA, Johanna, KAMOUN, Walid S, CHAN, Annie W, MCCLATCHEY, Andrea I, PLOTKIN, Scott R, JAIN, Rakesh K, DI TOMASO, Emmanuelle
Published in Cancer research (Chicago, Ill.) (01.05.2010)
Published in Cancer research (Chicago, Ill.) (01.05.2010)
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Journal Article
HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B
Kirouac, Daniel C, Du, Jinyan, Lahdenranta, Johanna, Onsum, Matthew D, Nielsen, Ulrik B, Schoeberl, Birgit, McDonagh, Charlotte F
Published in PLoS computational biology (01.04.2016)
Published in PLoS computational biology (01.04.2016)
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Journal Article
BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism
Hurov, Kristen, Lahdenranta, Johanna, Upadhyaya, Punit, Haines, Eric, Cohen, Heather, Repash, Elizabeth, Kanakia, Drasti, Ma, Jun, Kristensson, Julia, You, Fanglei, Campbell, Carly, Witty, David, Kelly, Mike, Blakemore, Stephen, Jeffrey, Phil, McDonnell, Kevin, Brandish, Philip, Keen, Nicholas
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Targeted Induction of Lung Endothelial Cell Apoptosis Causes Emphysema-like Changes in the Mouse
Giordano, Ricardo J., Lahdenranta, Johanna, Zhen, Lijie, Chukwueke, Ugonma, Petrache, Irina, Langley, Robert R., Fidler, Isaiah J., Pasqualini, Renata, Tuder, Rubin M., Arap, Wadih
Published in The Journal of biological chemistry (24.10.2008)
Published in The Journal of biological chemistry (24.10.2008)
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Journal Article
826 Establishing the preclinical/translational PK/PD relationship for BT7480, a nectin-4/CD137 Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)
Mistry, Hitesh, Ortega, Fernando, Lahdenranta, Johanna, Upadhyaya, Punit, Hurov, Kristen, Jeffrey, Phil, Chassagnole, Christophe
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist
Upadhyaya, Punit, Lahdenranta, Johanna, Hurov, Kristen, Battula, Sailaja, Dods, Rachel, Haines, Eric, Kleyman, Marianna, Kristensson, Julia, Kublin, Jessica, Lani, Rachid, Ma, Jun, Mudd, Gemma, Repash, Elizabeth, Van Rietschoten, Katerine, Stephen, Tom, You, Fanglei, Harrison, Helen, Chen, Liuhong, McDonnell, Kevin, Brandish, Philip, Keen, Nicholas
Published in Journal for immunotherapy of cancer (01.01.2021)
Published in Journal for immunotherapy of cancer (01.01.2021)
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Journal Article
888 An integrative approach to optimize a synthetic EphA2/CD137 agonist: balancing potency, physiochemical properties, and pharmacokinetics to achieve robust anti-tumor activity
Upadhyaya, Punit, Mudd, Gemma, Hurov, Kristen, Lahdenranta, Johanna, Repash, Elizabeth, Kristensson, Julia, McDonnell, Kevin, Brandish, Philip, Jeffrey, Phil, Keen, Nicholas
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948)
Raut, Chandrajit P, Boucher, Yves, Duda, Dan G, Morgan, Jeffrey A, Quek, Richard, Ancukiewicz, Marek, Lahdenranta, Johanna, Eder, J Paul, Demetri, George D, Jain, Rakesh K
Published in PloS one (07.02.2012)
Published in PloS one (07.02.2012)
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Journal Article
CD13/APN is activated by angiogenic signals and is essential for capillary tube formation
Bhagwat, Shripad V., Lahdenranta, Johanna, Giordano, Ricardo, Arap, Wadih, Pasqualini, Renata, Shapiro, Linda H.
Published in Blood (01.02.2001)
Published in Blood (01.02.2001)
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Journal Article
2 Quantitation of CD137 and Nectin-4 expression across multiple tumor types to support indication selection for BT7480, a Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)
Cohen, Heather, Campbell, Carly, Hurov, Kristen, Lahdenranta, Johanna, Gelb, Tara, Galbraith, David, Rozelle, Dan, Nagy, Mate, Au, Qingyan, Parnell, Erinn, Brandish, Phil, Hazard, Sebastien, Smethurst, Dominic, Keen, Nicholas, Blakemore, Stephen
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
700 EphA2/CD137 Bicycle tumor-targeted immune cell agonists (TICAsTM) induce tumor regressions, immunogenic memory, and reprogramming of the tumor immune microenvironment
Hurov, Kristen, lahdenranta, Johanna, Mudd, Gemma, Upadhyaya, Punit, Repash, Elizabeth, Ma, Jun, Kristensson, Julia, Kleyman, Marianna, Kublin, Jessica, Chen, Liuhong, Haines, Eric, Battula, Sailaja, McDonnell, Kevin, Brandish, Philip, Keen, Nicholas
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11
Cardó-Vila, Marina, Zurita, Amado J, Giordano, Ricardo J, Sun, Jessica, Rangel, Roberto, Guzman-Rojas, Liliana, Anobom, Cristiane D, Valente, Ana P, Almeida, Fábio C L, Lahdenranta, Johanna, Kolonin, Mikhail G, Arap, Wadih, Pasqualini, Renata
Published in PloS one (20.10.2008)
Published in PloS one (20.10.2008)
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Journal Article
An Anti-Angiogenic State in Mice and Humans with Retinal Photoreceptor Cell Degeneration
Lahdenranta, Johanna, Pasqualini, Renata, Schlingemann, Reinier O., Hagedorn, Martin, Stallcup, William B., Bucana, Corazon D., Sidman, Richard L., Arap, Wadih
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2001)
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