Development of an ectopic huLiver model for Plasmodium liver stage infection
Samayoa-Reyes, Gabriela, Flaherty, Siobhan M, Wickham, Kristina S, Viera-Morilla, Sara, Strauch, Pamela M, Roth, Alison, Padrón, Laura, Jackson, Conner M, Meireles, Patricia, Calvo, David, Roobsoong, Wanlapa, Kangwanrangsan, Niwat, Sattabongkot, Jetsumon, Reichard, Gregory, Lafuente-Monasterio, Maria José, Rochford, Rosemary
Published in PloS one (16.03.2023)
Published in PloS one (16.03.2023)
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Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum
Ross, Leila Saxby, Lafuente-Monasterio, Maria José, Sakata-Kato, Tomoyo, Mandt, Rebecca E. K, Gamo, Francisco Javier, Wirth, Dyann F, Lukens, Amanda K
Published in ACS infectious diseases (13.04.2018)
Published in ACS infectious diseases (13.04.2018)
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A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.
Published in Nature communications (06.03.2017)
Published in Nature communications (06.03.2017)
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Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice
Zhan, Wenhu, Zhang, Hao, Ginn, John, Leung, Annie, Liu, Yi J., Michino, Mayako, Toita, Akinori, Okamoto, Rei, Wong, Tzu‐Tshin, Imaeda, Toshihiro, Hara, Ryoma, Yukawa, Takafumi, Chelebieva, Sevil, Tumwebaze, Patrick K., Lafuente‐Monasterio, Maria Jose, Martinez‐Martinez, Maria Santos, Vendome, Jeremie, Beuming, Thijs, Sato, Kenjiro, Aso, Kazuyoshi, Rosenthal, Philip J., Cooper, Roland A., Meinke, Peter T., Nathan, Carl F., Kirkman, Laura A., Lin, Gang
Published in Angewandte Chemie International Edition (19.04.2021)
Published in Angewandte Chemie International Edition (19.04.2021)
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In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model
Mandt, Rebecca E K, Lafuente-Monasterio, Maria Jose, Sakata-Kato, Tomoyo, Luth, Madeline R, Segura, Delfina, Pablos-Tanarro, Alba, Viera, Sara, Magan, Noemi, Ottilie, Sabine, Winzeler, Elizabeth A, Lukens, Amanda K, Gamo, Francisco Javier, Wirth, Dyann F
Published in Science translational medicine (04.12.2019)
Published in Science translational medicine (04.12.2019)
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A broad analysis of resistance development in the malaria parasite
Corey, Victoria C., Lukens, Amanda K., Istvan, Eva S., Lee, Marcus C. S., Franco, Virginia, Magistrado, Pamela, Coburn-Flynn, Olivia, Sakata-Kato, Tomoyo, Fuchs, Olivia, Gnädig, Nina F., Goldgof, Greg, Linares, Maria, Gomez-Lorenzo, Maria G., De Cózar, Cristina, Lafuente-Monasterio, Maria Jose, Prats, Sara, Meister, Stephan, Tanaseichuk, Olga, Wree, Melanie, Zhou, Yingyao, Willis, Paul A., Gamo, Francisco-Javier, Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.
Published in Nature communications (15.06.2016)
Published in Nature communications (15.06.2016)
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In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth
Ross, Leila S., Gamo, Francisco Javier, Lafuente-Monasterio, Maria José, Singh, Onkar M.P., Rowland, Paul, Wiegand, Roger C., Wirth, Dyann F.
Published in The Journal of biological chemistry (27.06.2014)
Published in The Journal of biological chemistry (27.06.2014)
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Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance
Mandt, Rebecca EK, Luth, Madeline R, Tye, Mark A, Mazitschek, Ralph, Ottilie, Sabine, Winzeler, Elizabeth A, Lafuente-Monasterio, Maria Jose, Gamo, Francisco Javier, Wirth, Dyann F, Lukens, Amanda K
Published in eLife (22.09.2023)
Published in eLife (22.09.2023)
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Novel Antitubercular 6‑Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies
Wilson, Colin R, Gessner, Richard K, Moosa, Atica, Seldon, Ronnett, Warner, Digby F, Mizrahi, Valerie, Soares de Melo, Candice, Simelane, Sandile B, Nchinda, Aloysius, Abay, Efrem, Taylor, Dale, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Boshoff, Helena I. M, Barry, Clifton E, Sirgel, Frederick A, van Helden, Paul, Harris, C. John, Gordon, Richard, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Boesche, Markus, Drewes, Gerard, Sanz, Olalla, Santos, Gracia, Rebollo-Lopez, Maria José, Urones, Beatriz, Selenski, Carolyn, Lafuente-Monasterio, Maria Jose, Axtman, Matthew, Lelièvre, Joël, Ballell, Lluis, Mueller, Rudolf, Street, Leslie J, Ghorpade, Sandeep R, Chibale, Kelly
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases
Matthews, Krista A, Senagbe, Kossi M, Nötzel, Christopher, Gonzales, Christopher A, Tong, Xinran, Rijo-Ferreira, Filipa, Bhanu, Natarajan V, Miguel-Blanco, Celia, Lafuente-Monasterio, Maria Jose, Garcia, Benjamin A, Kafsack, Björn F. C, Martinez, Elisabeth D
Published in ACS infectious diseases (08.05.2020)
Published in ACS infectious diseases (08.05.2020)
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Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L, White, John, Shackleford, David M, Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T, Garcia-Pérez, Adolfo, Fernandez, Jorge, Gamo, Francisco Javier, Waterson, David, Burrows, Jeremy N, Palmer, Michael J, Charman, Susan A, Rathod, Pradipsinh K, Phillips, Margaret A
Published in ACS omega (31.08.2018)
Published in ACS omega (31.08.2018)
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Journal Article
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice
Zhan, Wenhu, Zhang, Hao, Ginn, John, Leung, Annie, Liu, Yi J., Michino, Mayako, Toita, Akinori, Okamoto, Rei, Wong, Tzu‐Tshin, Imaeda, Toshihiro, Hara, Ryoma, Yukawa, Takafumi, Chelebieva, Sevil, Tumwebaze, Patrick K., Lafuente‐Monasterio, Maria Jose, Martinez‐Martinez, Maria Santos, Vendome, Jeremie, Beuming, Thijs, Sato, Kenjiro, Aso, Kazuyoshi, Rosenthal, Philip J., Cooper, Roland A., Meinke, Peter T., Nathan, Carl F., Kirkman, Laura A., Lin, Gang
Published in Angewandte Chemie (19.04.2021)
Published in Angewandte Chemie (19.04.2021)
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Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
Paquet, Tanya, Le Manach, Claire, Cabrera, Diego González, Younis, Yassir, Henrich, Philipp P, Abraham, Tara S, Lee, Marcus C S, Basak, Rajshekhar, Ghidelli-Disse, Sonja, Lafuente-Monasterio, María José, Bantscheff, Marcus, Ruecker, Andrea, Blagborough, Andrew M, Zakutansky, Sara E, Zeeman, Anne-Marie, White, Karen L, Shackleford, David M, Mannila, Janne, Morizzi, Julia, Scheurer, Christian, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Reader, Janette, Botha, Mariette, Dechering, Koen J, Sauerwein, Robert W, Tungtaeng, Anchalee, Vanachayangkul, Pattaraporn, Lim, Chek Shik, Burrows, Jeremy, Witty, Michael J, Marsh, Kennan C, Bodenreider, Christophe, Rochford, Rosemary, Solapure, Suresh M, Jiménez-Díaz, María Belén, Wittlin, Sergio, Charman, Susan A, Donini, Cristina, Campo, Brice, Birkholtz, Lyn-Marie, Hanson, Kirsten K, Drewes, Gerard, Kocken, Clemens H M, Delves, Michael J, Leroy, Didier, Fidock, David A, Waterson, David, Street, Leslie J, Chibale, Kelly
Published in Science translational medicine (26.04.2017)
Published in Science translational medicine (26.04.2017)
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Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
Published in Science (American Association for the Advancement of Science)
(30.08.2019)
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Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria
Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, El Mazouni, Farah, White, John, Shackleford, David M, Katneni, Kasiram, Chiu, Francis C. K, Barker, Helena, McLaren, Jenna, Crighton, Elly, Chen, Gong, Angulo-Barturen, Inigo, Jimenez-Diaz, Maria Belen, Ferrer, Santiago, Huertas-Valentin, Leticia, Martinez-Martinez, Maria Santos, Lafuente-Monasterio, Maria Jose, Chittimalla, Rajesh, Shahi, Shatrughan P, Wittlin, Sergio, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Tomchick, Diana, Rathod, Pradipsinh K, Palmer, Michael J, Charman, Susan A, Phillips, Margaret A
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
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Identification of Fast-Acting 2,6-Disithstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2R gamma(null) Mouse Model of Malaria
Nchinda, Aloysius T., Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzalez, Wicht, Kathryn J., Brunschwig, Christel, Njoroge, Mathew, Abay, Efrem, Taylor, Dale, Lawrence, Nina, Wittlin, Sergio, Jimenez-Diaz, Maria-Belen, Santos Martinez, Maria, Ferrer, Santiago, Angulo-Barturen, Inigo, Jose Lafuente-Monasterio, Maria, Duffy, James, Burrows, Jeremy, Street, Leslie J., Chibale, Kelly
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
Crowther, Gregory J, Hillesland, Heidi K, Keyloun, Katelyn R, Reid, Molly C, Lafuente-Monasterio, Maria Jose, Ghidelli-Disse, Sonja, Leonard, Stephen E, He, Panqing, Jones, Jackson C, Krahn, Mallory M, Mo, Jack S, Dasari, Kartheek S, Fox, Anna M W, Boesche, Markus, El Bakkouri, Majida, Rivas, Kasey L, Leroy, Didier, Hui, Raymond, Drewes, Gerard, Maly, Dustin J, Van Voorhis, Wesley C, Ojo, Kayode K
Published in PloS one (02.03.2016)
Published in PloS one (02.03.2016)
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Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis
Park, Yumi, Pacitto, Angela, Bayliss, Tracy, Cleghorn, Laura A. T, Wang, Zhe, Hartman, Travis, Arora, Kriti, Ioerger, Thomas R, Sacchettini, Jim, Rizzi, Menico, Donini, Stefano, Blundell, Tom L, Ascher, David B, Rhee, Kyu, Breda, Ardala, Zhou, Nian, Dartois, Veronique, Jonnala, Surendranadha Reddy, Via, Laura E, Mizrahi, Valerie, Epemolu, Ola, Stojanovski, Laste, Simeons, Fred, Osuna-Cabello, Maria, Ellis, Lucy, MacKenzie, Claire J, Smith, Alasdair R. C, Davis, Susan H, Murugesan, Dinakaran, Buchanan, Kirsteen I, Turner, Penelope A, Huggett, Margaret, Zuccotto, Fabio, Rebollo-Lopez, Maria Jose, Lafuente-Monasterio, Maria Jose, Sanz, Olalla, Diaz, Gracia Santos, Lelièvre, Joël, Ballell, Lluis, Selenski, Carolyn, Axtman, Matthew, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Bösche, Markus, Drewes, Gerard, Freiberg, Gail M, Kurnick, Matthew D, Srikumaran, Myron, Kempf, Dale J, Green, Simon R, Ray, Peter C, Read, Kevin, Wyatt, Paul, Barry, Clifton E, Boshoff, Helena I
Published in ACS infectious diseases (13.01.2017)
Published in ACS infectious diseases (13.01.2017)
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Journal Article
Validation of the protein kinase Pf CLK3 as a multistage cross-species malarial drug target
Alam, Mahmood M, Sanchez-Azqueta, Ana, Janha, Omar, Flannery, Erika L, Mahindra, Amit, Mapesa, Kopano, Char, Aditya B, Sriranganadane, Dev, Brancucci, Nicolas M B, Antonova-Koch, Yevgeniya, Crouch, Kathryn, Simwela, Nelson Victor, Millar, Scott B, Akinwale, Jude, Mitcheson, Deborah, Solyakov, Lev, Dudek, Kate, Jones, Carolyn, Zapatero, Cleofé, Doerig, Christian, Nwakanma, Davis C, Vázquez, Maria Jesús, Colmenarejo, Gonzalo, Lafuente-Monasterio, Maria Jose, Leon, Maria Luisa, Godoi, Paulo H C, Elkins, Jon M, Waters, Andrew P, Jamieson, Andrew G, Álvaro, Elena Fernández, Ranford-Cartwright, Lisa C, Marti, Matthias, Winzeler, Elizabeth A, Gamo, Francisco Javier, Tobin, Andrew B
Published in Science (American Association for the Advancement of Science) (30.08.2019)
Published in Science (American Association for the Advancement of Science) (30.08.2019)
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Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria
Nchinda, Aloysius T, Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Wicht, Kathryn J, Brunschwig, Christel, Njoroge, Mathew, Abay, Efrem, Taylor, Dale, Lawrence, Nina, Wittlin, Sergio, Jiménez-Díaz, María-Belén, Santos Martínez, María, Ferrer, Santiago, Angulo-Barturen, Iñigo, Lafuente-Monasterio, Maria Jose, Duffy, James, Burrows, Jeremy, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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