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Samayoa-Reyes, Gabriela, Flaherty, Siobhan M, Wickham, Kristina S, Viera-Morilla, Sara, Strauch, Pamela M, Roth, Alison, Padrón, Laura, Jackson, Conner M, Meireles, Patricia, Calvo, David, Roobsoong, Wanlapa, Kangwanrangsan, Niwat, Sattabongkot, Jetsumon, Reichard, Gregory, Lafuente-Monasterio, Maria José, Rochford, Rosemary
Published in PloS one (16.03.2023)
Published in PloS one (16.03.2023)
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A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.
Published in Nature communications (06.03.2017)
Published in Nature communications (06.03.2017)
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Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice
Zhan, Wenhu, Zhang, Hao, Ginn, John, Leung, Annie, Liu, Yi J., Michino, Mayako, Toita, Akinori, Okamoto, Rei, Wong, Tzu‐Tshin, Imaeda, Toshihiro, Hara, Ryoma, Yukawa, Takafumi, Chelebieva, Sevil, Tumwebaze, Patrick K., Lafuente‐Monasterio, Maria Jose, Martinez‐Martinez, Maria Santos, Vendome, Jeremie, Beuming, Thijs, Sato, Kenjiro, Aso, Kazuyoshi, Rosenthal, Philip J., Cooper, Roland A., Meinke, Peter T., Nathan, Carl F., Kirkman, Laura A., Lin, Gang
Published in Angewandte Chemie International Edition (19.04.2021)
Published in Angewandte Chemie International Edition (19.04.2021)
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Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance
Lukens, Amanda K., Ross, Leila Saxby, Heidebrecht, Richard, Gamo, Francisco Javier, Lafuente-Monasterio, Maria J., Booker, Michael L., Hartl, Daniel L., Wiegand, Roger C., Wirth, Dyann F.
Published in Proceedings of the National Academy of Sciences - PNAS (14.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (14.01.2014)
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Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum
Ross, Leila Saxby, Lafuente-Monasterio, Maria José, Sakata-Kato, Tomoyo, Mandt, Rebecca E. K, Gamo, Francisco Javier, Wirth, Dyann F, Lukens, Amanda K
Published in ACS infectious diseases (13.04.2018)
Published in ACS infectious diseases (13.04.2018)
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A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
Phillips, Margaret A, Lotharius, Julie, Marsh, Kennan, White, John, Dayan, Anthony, White, Karen L, Njoroge, Jacqueline W, El Mazouni, Farah, Lao, Yanbin, Kokkonda, Sreekanth, Tomchick, Diana R, Deng, Xiaoyi, Laird, Trevor, Bhatia, Sangeeta N, March, Sandra, Ng, Caroline L, Fidock, David A, Wittlin, Sergio, Lafuente-Monasterio, Maria, Benito, Francisco Javier Gamo, Alonso, Laura Maria Sanz, Martinez, Maria Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Haselden, John N, Louttit, James, Cui, Yi, Sridhar, Arun, Zeeman, Anna-Marie, Kocken, Clemens, Sauerwein, Robert, Dechering, Koen, Avery, Vicky M, Duffy, Sandra, Delves, Michael, Sinden, Robert, Ruecker, Andrea, Wickham, Kristina S, Rochford, Rosemary, Gahagen, Janet, Iyer, Lalitha, Riccio, Ed, Mirsalis, Jon, Bathhurst, Ian, Rueckle, Thomas, Ding, Xavier, Campo, Brice, Leroy, Didier, Rogers, M John, Rathod, Pradipsinh K, Burrows, Jeremy N, Charman, Susan A
Published in Science translational medicine (15.07.2015)
Published in Science translational medicine (15.07.2015)
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In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model
Mandt, Rebecca E K, Lafuente-Monasterio, Maria Jose, Sakata-Kato, Tomoyo, Luth, Madeline R, Segura, Delfina, Pablos-Tanarro, Alba, Viera, Sara, Magan, Noemi, Ottilie, Sabine, Winzeler, Elizabeth A, Lukens, Amanda K, Gamo, Francisco Javier, Wirth, Dyann F
Published in Science translational medicine (04.12.2019)
Published in Science translational medicine (04.12.2019)
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Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug
da Cruz, Filipa P., Martin, Cécilie, Buchholz, Kathrin, Lafuente-Monasterio, Maria J., Rodrigues, Tiago, Sönnichsen, Birte, Moreira, Rui, Gamo, Francisco-Javier, Marti, Matthias, Mota, Maria M., Hannus, Michael, Prudêncio, Miguel
Published in The Journal of infectious diseases (15.04.2012)
Published in The Journal of infectious diseases (15.04.2012)
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The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages
Arendse, Lauren B, Murithi, James M, Qahash, Tarrick, Pasaje, Charisse Flerida A, Godoy, Luiz C, Dey, Sumanta, Gibhard, Liezl, Ghidelli-Disse, Sonja, Drewes, Gerard, Bantscheff, Marcus, Lafuente-Monasterio, Maria J, Fienberg, Stephen, Wambua, Lynn, Gachuhi, Samuel, Coertzen, Dina, van der Watt, Mariëtte, Reader, Janette, Aswat, Ayesha S, Erlank, Erica, Venter, Nelius, Mittal, Nimisha, Luth, Madeline R, Ottilie, Sabine, Winzeler, Elizabeth A, Koekemoer, Lizette L, Birkholtz, Lyn-Marie, Niles, Jacquin C, Llinás, Manuel, Fidock, David A, Chibale, Kelly
Published in Science translational medicine (19.10.2022)
Published in Science translational medicine (19.10.2022)
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In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth
Ross, Leila S., Gamo, Francisco Javier, Lafuente-Monasterio, Maria José, Singh, Onkar M.P., Rowland, Paul, Wiegand, Roger C., Wirth, Dyann F.
Published in The Journal of biological chemistry (27.06.2014)
Published in The Journal of biological chemistry (27.06.2014)
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Novel Antitubercular 6‑Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies
Wilson, Colin R, Gessner, Richard K, Moosa, Atica, Seldon, Ronnett, Warner, Digby F, Mizrahi, Valerie, Soares de Melo, Candice, Simelane, Sandile B, Nchinda, Aloysius, Abay, Efrem, Taylor, Dale, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Boshoff, Helena I. M, Barry, Clifton E, Sirgel, Frederick A, van Helden, Paul, Harris, C. John, Gordon, Richard, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Boesche, Markus, Drewes, Gerard, Sanz, Olalla, Santos, Gracia, Rebollo-Lopez, Maria José, Urones, Beatriz, Selenski, Carolyn, Lafuente-Monasterio, Maria Jose, Axtman, Matthew, Lelièvre, Joël, Ballell, Lluis, Mueller, Rudolf, Street, Leslie J, Ghorpade, Sandeep R, Chibale, Kelly
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
Crowther, Gregory J, Hillesland, Heidi K, Keyloun, Katelyn R, Reid, Molly C, Lafuente-Monasterio, Maria Jose, Ghidelli-Disse, Sonja, Leonard, Stephen E, He, Panqing, Jones, Jackson C, Krahn, Mallory M, Mo, Jack S, Dasari, Kartheek S, Fox, Anna M W, Boesche, Markus, El Bakkouri, Majida, Rivas, Kasey L, Leroy, Didier, Hui, Raymond, Drewes, Gerard, Maly, Dustin J, Van Voorhis, Wesley C, Ojo, Kayode K
Published in PloS one (02.03.2016)
Published in PloS one (02.03.2016)
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Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases
Matthews, Krista A, Senagbe, Kossi M, Nötzel, Christopher, Gonzales, Christopher A, Tong, Xinran, Rijo-Ferreira, Filipa, Bhanu, Natarajan V, Miguel-Blanco, Celia, Lafuente-Monasterio, Maria Jose, Garcia, Benjamin A, Kafsack, Björn F. C, Martinez, Elisabeth D
Published in ACS infectious diseases (08.05.2020)
Published in ACS infectious diseases (08.05.2020)
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A broad analysis of resistance development in the malaria parasite
Corey, Victoria C., Lukens, Amanda K., Istvan, Eva S., Lee, Marcus C. S., Franco, Virginia, Magistrado, Pamela, Coburn-Flynn, Olivia, Sakata-Kato, Tomoyo, Fuchs, Olivia, Gnädig, Nina F., Goldgof, Greg, Linares, Maria, Gomez-Lorenzo, Maria G., De Cózar, Cristina, Lafuente-Monasterio, Maria Jose, Prats, Sara, Meister, Stephan, Tanaseichuk, Olga, Wree, Melanie, Zhou, Yingyao, Willis, Paul A., Gamo, Francisco-Javier, Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.
Published in Nature communications (15.06.2016)
Published in Nature communications (15.06.2016)
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Quinolin-4(1H)‑imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria
Rodrigues, Tiago, da Cruz, Filipa P, Lafuente-Monasterio, Maria J, Gonçalves, Daniel, Ressurreição, Ana S, Sitoe, Ana R, Bronze, Maria R, Gut, Jiri, Schneider, Gisbert, Mota, Maria M, Rosenthal, Philip J, Prudêncio, Miguel, Gamo, Francisco-Javier, Lopes, Francisca, Moreira, Rui
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance
Mandt, Rebecca EK, Luth, Madeline R, Tye, Mark A, Mazitschek, Ralph, Ottilie, Sabine, Winzeler, Elizabeth A, Lafuente-Monasterio, Maria Jose, Gamo, Francisco Javier, Wirth, Dyann F, Lukens, Amanda K
Published in eLife (22.09.2023)
Published in eLife (22.09.2023)
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Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L, White, John, Shackleford, David M, Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T, Garcia-Pérez, Adolfo, Fernandez, Jorge, Gamo, Francisco Javier, Waterson, David, Burrows, Jeremy N, Palmer, Michael J, Charman, Susan A, Rathod, Pradipsinh K, Phillips, Margaret A
Published in ACS omega (31.08.2018)
Published in ACS omega (31.08.2018)
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Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice
Zhan, Wenhu, Zhang, Hao, Ginn, John, Leung, Annie, Liu, Yi J., Michino, Mayako, Toita, Akinori, Okamoto, Rei, Wong, Tzu‐Tshin, Imaeda, Toshihiro, Hara, Ryoma, Yukawa, Takafumi, Chelebieva, Sevil, Tumwebaze, Patrick K., Lafuente‐Monasterio, Maria Jose, Martinez‐Martinez, Maria Santos, Vendome, Jeremie, Beuming, Thijs, Sato, Kenjiro, Aso, Kazuyoshi, Rosenthal, Philip J., Cooper, Roland A., Meinke, Peter T., Nathan, Carl F., Kirkman, Laura A., Lin, Gang
Published in Angewandte Chemie (19.04.2021)
Published in Angewandte Chemie (19.04.2021)
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Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
Paquet, Tanya, Le Manach, Claire, Cabrera, Diego González, Younis, Yassir, Henrich, Philipp P, Abraham, Tara S, Lee, Marcus C S, Basak, Rajshekhar, Ghidelli-Disse, Sonja, Lafuente-Monasterio, María José, Bantscheff, Marcus, Ruecker, Andrea, Blagborough, Andrew M, Zakutansky, Sara E, Zeeman, Anne-Marie, White, Karen L, Shackleford, David M, Mannila, Janne, Morizzi, Julia, Scheurer, Christian, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Reader, Janette, Botha, Mariette, Dechering, Koen J, Sauerwein, Robert W, Tungtaeng, Anchalee, Vanachayangkul, Pattaraporn, Lim, Chek Shik, Burrows, Jeremy, Witty, Michael J, Marsh, Kennan C, Bodenreider, Christophe, Rochford, Rosemary, Solapure, Suresh M, Jiménez-Díaz, María Belén, Wittlin, Sergio, Charman, Susan A, Donini, Cristina, Campo, Brice, Birkholtz, Lyn-Marie, Hanson, Kirsten K, Drewes, Gerard, Kocken, Clemens H M, Delves, Michael J, Leroy, Didier, Fidock, David A, Waterson, David, Street, Leslie J, Chibale, Kelly
Published in Science translational medicine (26.04.2017)
Published in Science translational medicine (26.04.2017)
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