Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
Ladds, Marcus J G W, Pastor-Fernández, Andrés, Popova, Gergana, van Leeuwen, Ingeborg M M, Eng, Kai Er, Drummond, Catherine J, Johansson, Lars, Svensson, Richard, Westwood, Nicholas J, McCarthy, Anna R, Tholander, Fredrik, Popa, Mihaela, Lane, David P, McCormack, Emmet, McInerney, Gerald M, Bhatia, Ravi, Laín, Sonia
Published in PloS one (23.04.2018)
Published in PloS one (23.04.2018)
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Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins
Gault, Joseph, Liko, Idlir, Landreh, Michael, Shutin, Denis, Bolla, Jani Reddy, Jefferies, Damien, Agasid, Mark, Yen, Hsin-Yung, Ladds, Marcus J. G. W., Lane, David P., Khalid, Syma, Mullen, Christopher, Remes, Philip M., Huguet, Romain, McAlister, Graeme, Goodwin, Michael, Viner, Rosa, Syka, John E.P., Robinson, Carol V.
Published in Nature methods (01.05.2020)
Published in Nature methods (01.05.2020)
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Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
Popova, Gergana, Ladds, Marcus J. G. W, Johansson, Lars, Saleh, Aljona, Larsson, Johanna, Sandberg, Lars, Sahlberg, Sara Häggblad, Qian, Weixing, Gullberg, Hjalmar, Garg, Neeraj, Gustavsson, Anna-Lena, Haraldsson, Martin, Lane, David, Yngve, Ulrika, Lain, Sonia
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Journal Article
ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis
Long, Jaclyn S, Kania, Elżbieta, McEwan, David G, Barthet, Valentin J A, Brucoli, Martina, Ladds, Marcus J G W, Nössing, Christoph, Ryan, Kevin M
Published in Proceedings of the National Academy of Sciences - PNAS (12.07.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (12.07.2022)
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Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
Ladds, Marcus J. G.W., Popova, Gergana, Pastor-Fernández, Andrés, Kannan, Srinivasaraghavan, van Leeuwen, Ingeborg M.M., Håkansson, Maria, Walse, Björn, Tholander, Fredrik, Bhatia, Ravi, Verma, Chandra S., Lane, David P., Laín, Sonia
Published in The Journal of biological chemistry (25.12.2020)
Published in The Journal of biological chemistry (25.12.2020)
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Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Fernández, Andrés Pastor, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Published in Nature communications (18.08.2023)
Published in Nature communications (18.08.2023)
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Journal Article
Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase
Costeira-Paulo, Joana, Gault, Joseph, Popova, Gergana, Ladds, Marcus J.G.W., van Leeuwen, Ingeborg M.M., Sarr, Médoune, Olsson, Anders, Lane, David P., Laín, Sonia, Marklund, Erik G., Landreh, Michael
Published in Cell chemical biology (15.03.2018)
Published in Cell chemical biology (15.03.2018)
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Journal Article
Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver
Barthet, Valentin J A, Brucoli, Martina, Ladds, Marcus J G W, Nössing, Christoph, Kiourtis, Christos, Baudot, Alice D, O'Prey, James, Zunino, Barbara, Müller, Miryam, May, Stephanie, Nixon, Colin, Long, Jaclyn S, Bird, Thomas G, Ryan, Kevin M
Published in Science advances (01.06.2021)
Published in Science advances (01.06.2021)
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Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner
McCarthy, Anna R, Sachweh, Marijke C C, Higgins, Maureen, Campbell, Johanna, Drummond, Catherine J, van Leeuwen, Ingeborg M M, Pirrie, Lisa, Ladds, Marcus J G W, Westwood, Nicholas J, Laín, Sonia
Published in Molecular cancer therapeutics (01.04.2013)
Published in Molecular cancer therapeutics (01.04.2013)
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Journal Article
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Published in Nature communications (22.05.2018)
Published in Nature communications (22.05.2018)
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Journal Article
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Published in Nature communications (16.03.2018)
Published in Nature communications (16.03.2018)
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Journal Article
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
Ladds, Marcus J G W, Popova, Gergana, Pastor-Fernández, Andrés, Kannan, Srinivasaraghavan, van Leeuwen, Ingeborg M M, Håkansson, Maria, Walse, Björn, Tholander, Fredrik, Bhatia, Ravi, Verma, Chandra S, Lane, David P, Laín, Sonia
Published in The Journal of biological chemistry (25.12.2020)
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Published in The Journal of biological chemistry (25.12.2020)
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