High‐affinity interactions and signal transduction between Aβ oligomers and TREM2
Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E
Published in EMBO molecular medicine (01.11.2018)
Published in EMBO molecular medicine (01.11.2018)
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Journal Article
APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model
Deyts, Carole, Clutter, Mary, Pierce, Nicholas, Chakrabarty, Paramita, Ladd, Thomas B., Goddi, Anna, Rosario, Awilda M., Cruz, Pedro, Vetrivel, Kulandaivelu, Wagner, Steven L., Thinakaran, Gopal, Golde, Todd E., Parent, Angèle T.
Published in Cell reports (Cambridge) (30.04.2019)
Published in Cell reports (Cambridge) (30.04.2019)
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Journal Article
Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity
Jung, Joo In, Premraj, Sasha, Cruz, Pedro E, Ladd, Thomas B, Kwak, Yewon, Koo, Edward H, Felsenstein, Kevin M, Golde, Todd E, Ran, Yong
Published in PloS one (28.10.2014)
Published in PloS one (28.10.2014)
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Journal Article
The effects of land management (grazing intensity) vs. the effects of topography, soil properties, vegetation type, and climate on soil carbon concentration in Southern Patagonia
Peri, P.L., Ladd, B., Lasagno, R.G., Martínez Pastur, G.
Published in Journal of arid environments (01.11.2016)
Published in Journal of arid environments (01.11.2016)
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Journal Article
Designing antibodies against LRRK2-targeted tau epitopes
Hamm, Matthew, Ladd, Thomas B, Levites, Yona, Golde, Todd E, Giasson, Benoit I, Lewis, Jada
Published in PloS one (27.09.2018)
Published in PloS one (27.09.2018)
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Journal Article
Regulation of Cocaine Reward by CREB
Carlezon, William A., Thome, Johannes, Olson, Valerie G., Lane-Ladd, Sarah B., Brodkin, Edward S., Hiroi, Noboru, Duman, Ronald S., Neve, Rachael L., Nestler, Eric J.
Published in Science (American Association for the Advancement of Science) (18.12.1998)
Published in Science (American Association for the Advancement of Science) (18.12.1998)
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Journal Article
γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
Lessard, Christian B, Rodriguez, Edgardo, Ladd, Thomas B, Minter, Lisa M, Osborne, Barbara A, Miele, Lucio, Golde, Todd E, Ran, Yong
Published in Alzheimer's research & therapy (19.05.2020)
Published in Alzheimer's research & therapy (19.05.2020)
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Journal Article
Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor
Nyborg, Andrew C., Kornilova, Anna Y., Jansen, Karen, Ladd, Thomas B., Wolfe, Michael S., Golde, Todd E.
Published in The Journal of biological chemistry (09.04.2004)
Published in The Journal of biological chemistry (09.04.2004)
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Journal Article
A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin
Nyborg, Andrew C, Jansen, Karen, Ladd, Thomas B, Fauq, Abdul, Golde, Todd E
Published in The Journal of biological chemistry (08.10.2004)
Published in The Journal of biological chemistry (08.10.2004)
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Journal Article
CREB (cAMP Response Element-Binding Protein) in the Locus Coeruleus: Biochemical, Physiological, and Behavioral Evidence for a Role in Opiate Dependence
Lane-Ladd, Sarah B, Pineda, Joseba, Boundy, Virginia A, Pfeuffer, T, Krupinski, John, Aghajanian, George K, Nestler, Eric J
Published in The Journal of neuroscience (15.10.1997)
Published in The Journal of neuroscience (15.10.1997)
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Journal Article
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates
Nyborg, Andrew C, Ladd, Thomas B, Zwizinski, Craig W, Lah, James J, Golde, Todd E
Published in Molecular neurodegeneration (12.06.2006)
Published in Molecular neurodegeneration (12.06.2006)
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Journal Article
Short Aβ peptides attenuate Aβ42 toxicity in vivo
Moore, Brenda D, Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E, Ceballos-Diaz, Carolina, Ladd, Thomas B, Ran, Yong, Levites, Yona, Kukar, Thomas L, Kurian, Justin J, McKenna, Robert, Koo, Edward H, Borchelt, David R, Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E
Published in The Journal of experimental medicine (02.01.2018)
Published in The Journal of experimental medicine (02.01.2018)
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Journal Article
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells
Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong
Published in The Journal of biological chemistry (19.07.2019)
Published in The Journal of biological chemistry (19.07.2019)
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Journal Article
Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach
Niculescu, A B, Levey, D F, Phalen, P L, Le-Niculescu, H, Dainton, H D, Jain, N, Belanger, E, James, A, George, S, Weber, H, Graham, D L, Schweitzer, R, Ladd, T B, Learman, R, Niculescu, E M, Vanipenta, N P, Khan, F N, Mullen, J, Shankar, G, Cook, S, Humbert, C, Ballew, A, Yard, M, Gelbart, T, Shekhar, A, Schork, N J, Kurian, S M, Sandusky, G E, Salomon, D R
Published in Molecular psychiatry (01.11.2015)
Published in Molecular psychiatry (01.11.2015)
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Journal Article
Sexual dimorphism in cerebellar structure, function, and response to environmental perturbations
Nguon, K., Ladd, B., Baxter, M.G., Sajdel-Sulkowska, E.M.
Published in Creating Coordination in the Cerebellum (01.01.2005)
Published in Creating Coordination in the Cerebellum (01.01.2005)
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