Androgen receptor-binding sites are highly mutated in prostate cancer
Morova, Tunç, McNeill, Daniel R, Lallous, Nada, Gönen, Mehmet, Dalal, Kush, Wilson, 3rd, David M, Gürsoy, Attila, Keskin, Özlem, Lack, Nathan A
Published in Nature communications (11.02.2020)
Published in Nature communications (11.02.2020)
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Dynamic phase separation of the androgen receptor and its coactivators key to regulate gene expression
Zhang, Fan, Biswas, Maitree, Massah, Shabnam, Lee, Joseph, Lingadahalli, Shreyas, Wong, Samantha, Wells, Christopher, Foo, Jane, Khan, Nabeel, Morin, Helene, Saxena, Neetu, Kung, Sonia H Y, Sun, Bei, Parra Nuñez, Ana Karla, Sanchez, Christophe, Chan, Novia, Ung, Lauren, Altıntaş, Umut Berkay, Bui, Jennifer M, Wang, Yuzhuo, Fazli, Ladan, Oo, Htoo Zarni, Rennie, Paul S, Lack, Nathan A, Cherkasov, Artem, Gleave, Martin E, Gsponer, Jörg, Lallous, Nada
Published in Nucleic acids research (11.01.2023)
Published in Nucleic acids research (11.01.2023)
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Optimized high-throughput screening of non-coding variants identified from genome-wide association studies
Morova, Tunc, Ding, Yi, Huang, Chia-Chi F, Sar, Funda, Schwarz, Tommer, Giambartolomei, Claudia, Baca, Sylvan C, Grishin, Dennis, Hach, Faraz, Gusev, Alexander, Freedman, Matthew L, Pasaniuc, Bogdan, Lack, Nathan A
Published in Nucleic acids research (22.02.2023)
Published in Nucleic acids research (22.02.2023)
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Androgen Receptor-Mediated Transcription in Prostate Cancer
Özturan, Doğancan, Morova, Tunç, Lack, Nathan A
Published in Cells (Basel, Switzerland) (05.03.2022)
Published in Cells (Basel, Switzerland) (05.03.2022)
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Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening
Lack, Nathan A, Axerio-Cilies, Peter, Tavassoli, Peyman, Han, Frank Q, Chan, Ka Hong, Feau, Clementine, LeBlanc, Eric, Guns, Emma Tomlinson, Guy, R. Kiplin, Rennie, Paul S, Cherkasov, Artem
Published in Journal of medicinal chemistry (22.12.2011)
Published in Journal of medicinal chemistry (22.12.2011)
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Functional mapping of androgen receptor enhancer activity
Huang, Chia-Chi Flora, Lingadahalli, Shreyas, Morova, Tunc, Ozturan, Dogancan, Hu, Eugene, Yu, Ivan Pak Lok, Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Sar, Funda, van der Poel, Henk, Altintas, Umut Berkay, Saffarzadeh, Mohammadali, Le Bihan, Stephane, McConeghy, Brian, Gokbayrak, Bengul, Feng, Felix Y, Gleave, Martin E, Bergman, Andries M, Collins, Colin, Hach, Faraz, Zwart, Wilbert, Emberly, Eldon, Lack, Nathan A
Published in Genome Biology (11.05.2021)
Published in Genome Biology (11.05.2021)
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Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae
Garipler, Görkem, Mutlu, Nebibe, Lack, Nathan A., Dunn, Cory D.
Published in Proceedings of the National Academy of Sciences - PNAS (28.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (28.01.2014)
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Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential
Kneppers, Jeroen, Severson, Tesa M, Siefert, Joseph C, Schol, Pieter, Joosten, Stacey E P, Yu, Ivan Pak Lok, Huang, Chia-Chi Flora, Morova, Tunç, Altıntaş, Umut Berkay, Giambartolomei, Claudia, Seo, Ji-Heui, Baca, Sylvan C, Carneiro, Isa, Emberly, Eldon, Pasaniuc, Bogdan, Jerónimo, Carmen, Henrique, Rui, Freedman, Matthew L, Wessels, Lodewyk F A, Lack, Nathan A, Bergman, Andries M, Zwart, Wilbert
Published in Nature communications (30.11.2022)
Published in Nature communications (30.11.2022)
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Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2‑((2-phenoxyethyl) thio)‑1H‑benzimidazole Derivatives
Munuganti, Ravi Shashi Nayana, Leblanc, Eric, Axerio-Cilies, Peter, Labriere, Christophe, Frewin, Kate, Singh, Kriti, Hassona, Mohamed D. H, Lack, Nathan A, Li, Huifang, Ban, Fuqiang, Tomlinson Guns, Emma, Young, Robert, Rennie, Paul S, Cherkasov, Artem
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Inhibitors of Androgen Receptor Activation Function-2 (AF2) Site Identified through Virtual Screening
Axerio-Cilies, Peter, Lack, Nathan A, Nayana, M. Ravi Shashi, Chan, Ka Hong, Yeung, Anthony, Leblanc, Eric, Guns, Emma S. Tomlinson, Rennie, Paul S, Cherkasov, Artem
Published in Journal of medicinal chemistry (22.09.2011)
Published in Journal of medicinal chemistry (22.09.2011)
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Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer
Ban, Fuqiang, Leblanc, Eric, Cavga, Ayse Derya, Huang, Chia-Chi Flora, Flory, Mark R, Zhang, Fan, Chang, Matthew E K, Morin, Hélène, Lallous, Nada, Singh, Kriti, Gleave, Martin E, Mohammed, Hisham, Rennie, Paul S, Lack, Nathan A, Cherkasov, Artem
Published in Cancers (12.07.2021)
Published in Cancers (12.07.2021)
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EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities
Yedier-Bayram, Ozlem, Gokbayrak, Bengul, Kayabolen, Alisan, Aksu, Ali Cenk, Cavga, Ayse Derya, Cingöz, Ahmet, Kala, Ezgi Yagmur, Karabiyik, Goktug, Günsay, Rauf, Esin, Beril, Morova, Tunc, Uyulur, Fırat, Syed, Hamzah, Philpott, Martin, Cribbs, Adam P, Kung, Sonia H Y, Lack, Nathan A, Onder, Tamer T, Bagci-Onder, Tugba
Published in Cell death & disease (16.08.2022)
Published in Cell death & disease (16.08.2022)
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Characterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol Metabolism
Lack, Nathan A., Yam, Katherine C., Lowe, Edward D., Horsman, Geoff P., Owen, Robin L., Sim, Edith, Eltis, Lindsay D.
Published in The Journal of biological chemistry (01.01.2010)
Published in The Journal of biological chemistry (01.01.2010)
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Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours
Dada, Sarah, Ellis, Samantha L S, Wood, Christi, Nohara, Lilian L, Dreier, Carola, Garcia, Nicolas H, Saranchova, Iryna, Munro, Lonna, Pfeifer, Cheryl G, Eyford, Brett A, Kari, Suresh, Garrovillas, Emmanuel, Caspani, Giorgia, Al Haddad, Eliana, Gray, Patrick W, Morova, Tunc, Lack, Nathan A, Andersen, Raymond J, Tjoelker, Larry, Jefferies, Wilfred A
Published in Frontiers in immunology (22.02.2023)
Published in Frontiers in immunology (22.02.2023)
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Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours
Ellis, Samantha L. S., Dada, Sarah, Nohara, Lilian L., Saranchova, Iryna, Munro, Lonna, Pfeifer, Cheryl G., Eyford, Brett A., Morova, Tunc, Williams, David E., Cheng, Ping, Lack, Nathan A., Andersen, Raymond J., Jefferies, Wilfred A.
Published in Frontiers in pharmacology (10.08.2023)
Published in Frontiers in pharmacology (10.08.2023)
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Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Ozyerli-Goknar, Ezgi, Kala, Ezgi Yagmur, Aksu, Ali Cenk, Bulut, Ipek, Cingöz, Ahmet, Nizamuddin, Sheikh, Biniossek, Martin, Seker-Polat, Fidan, Morova, Tunc, Aztekin, Can, Kung, Sonia H. Y., Syed, Hamzah, Tuncbag, Nurcan, Gönen, Mehmet, Philpott, Martin, Cribbs, Adam P., Acilan, Ceyda, Lack, Nathan A., Onder, Tamer T., Timmers, H. T. Marc, Bagci-Onder, Tugba
Published in Cell communication and signaling (16.11.2023)
Published in Cell communication and signaling (16.11.2023)
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KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL
Kurt, Ibrahim Cagri, Sur, Ilknur, Kaya, Ezgi, Cingoz, Ahmet, Kazancioglu, Selena, Kahya, Zeynep, Toparlak, Omer Duhan, Senbabaoglu, Filiz, Kaya, Zeynep, Ozyerli, Ezgi, Karahüseyinoglu, Sercin, Lack, Nathan A, Gümüs, Zeynep H, Onder, Tamer T, Bagci-Onder, Tugba
Published in Cell death & disease (29.06.2017)
Published in Cell death & disease (29.06.2017)
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Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis
Lack, Nathan A, Kawamura, Akane, Fullam, Elizabeth, Laurieri, Nicola, Beard, Stacey, Russell, Angela J, Evangelopoulos, Dimitrios, Westwood, Isaac, Sim, Edith
Published in Biochemical journal (01.03.2009)
Published in Biochemical journal (01.03.2009)
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