The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging
Zhang, Lei, Chen, Laigao, Beck, Elizabeth M, Chappie, Thomas A, Coelho, Richard V, Doran, Shawn D, Fan, Kuo-Hsien, Helal, Christopher J, Humphrey, John M, Hughes, Zoe, Kuszpit, Kyle, Lachapelle, Erik A, Lazzaro, John T, Lee, Chewah, Mather, Robert J, Patel, Nandini C, Skaddan, Marc B, Sciabola, Simone, Verhoest, Patrick R, Young, Joseph M, Zasadny, Kenneth, Villalobos, Anabella
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Huard, Kim, Ahn, Kay, Amor, Paul, Beebe, David A, Borzilleri, Kris A, Chrunyk, Boris A, Coffey, Steven B, Cong, Yang, Conn, Edward L, Culp, Jeffrey S, Dowling, Matthew S, Gorgoglione, Matthew F, Gutierrez, Jemy A, Knafels, John D, Lachapelle, Erik A, Pandit, Jayvardhan, Parris, Kevin D, Perez, Sylvie, Pfefferkorn, Jeffrey A, Price, David A, Raymer, Brian, Ross, Trenton T, Shavnya, Andre, Smith, Aaron C, Subashi, Timothy A, Tesz, Gregory J, Thuma, Benjamin A, Tu, Meihua, Weaver, John D, Weng, Yan, Withka, Jane M, Xing, Gang, Magee, Thomas V
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Discovery of N–X anomeric amides as electrophilic halogenation reagents
Wang, Yu, Bi, Cheng, Kawamata, Yu, Grant, Lauren N., Samp, Lacey, Richardson, Paul F., Zhang, Shasha, Harper, Kaid C., Palkowitz, Maximilian D., Vasilopoulos, Aristidis, Collins, Michael R., Oderinde, Martins S., Tyrol, Chet C., Chen, Doris, LaChapelle, Erik A., Bailey, Jake B., Qiao, Jennifer X., Baran, Phil S.
Published in Nature chemistry (01.09.2024)
Published in Nature chemistry (01.09.2024)
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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor
Butler, Christopher R., Popiolek, Michael, McAllister, Laura A., LaChapelle, Erik A., Kramer, Melissa, Beck, Elizabeth M., Mente, Scot, Brodney, Michael A., Brown, Matthew, Gilbert, Adam, Helal, Chris, Ogilvie, Kevin, Starr, Jeremy, Uccello, Daniel, Grimwood, Sarah, Edgerton, Jeremy, Garst-Orozco, Jonathan, Kozak, Rouba, Lotarski, Susan, Rossi, Amie, Smith, Deborah, O’Connor, Rebecca, Lazzaro, John, Steppan, Claire, Steyn, Stefanus J.
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
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Journal Article
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M 4 Muscarinic Acetylcholine Receptor
Butler, Christopher R, Popiolek, Michael, McAllister, Laura A, LaChapelle, Erik A, Kramer, Melissa, Beck, Elizabeth M, Mente, Scot, Brodney, Michael A, Brown, Matthew, Gilbert, Adam, Helal, Chris, Ogilvie, Kevin, Starr, Jeremy, Uccello, Daniel, Grimwood, Sarah, Edgerton, Jeremy, Garst-Orozko, Jonathan, Kozak, Rouba, Lotarski, Susan, Rossi, Amie, Smith, Deborah, O'Connor, Rebecca, Lazzaro, John, Steppan, Claire, Steyn, Stefanus J
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
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Fluorophosphonates on‐Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis
Dutra, Jason K., Foley, Timothy L., Huang, Zhen, Fisher, Ethan L., Lachapelle, Erik A., Mahapatra, Subham, Ogilvie, Kevin, Butler, Todd W., Bellenger, Justin, Devraj Majmudar, Jaimeen, am Ende, Christopher W.
Published in Chembiochem : a European journal of chemical biology (14.05.2021)
Published in Chembiochem : a European journal of chemical biology (14.05.2021)
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Strategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres
Obach, Ronald Scott, LaChapelle, Erik A., Brodney, Michael A., Vanase-Frawley, Michelle, Kauffman, Gregory W., Sawant-Basak, Aarti
Published in Xenobiotica (01.12.2016)
Published in Xenobiotica (01.12.2016)
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Intramolecular Ring-Opening Decomposition of Aryl Azetidines
Bai, Guoyun, O’Connell, Thomas N, Brodney, Michael A, Butler, Christopher R, Czabaniuk, Lara C, Gilbert, Adam M, LaChapelle, Erik A, Li, Chao, McAllister, Laura A, Ogilvie, Kevin, Philippe, Laurence, Salomon-Ferrer, Romelia, Shapiro, Michael J, Starr, Jeremy T, Uccello, Daniel P, Withka, Jane M, Yan, Jiangli, Brown, Matthew F
Published in ACS medicinal chemistry letters (14.10.2021)
Published in ACS medicinal chemistry letters (14.10.2021)
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Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres
Yang, Qingyi, Lachapelle, Erik A, Kablaoui, Natasha M, Webb, Damien, Popiolek, Michael, Grimwood, Sarah, Kozak, Rouba, O’Connor, Rebecca E, Lazzaro, John T, Butler, Christopher R, Zhang, Lei
Published in ACS medicinal chemistry letters (13.06.2019)
Published in ACS medicinal chemistry letters (13.06.2019)
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Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, LaChapelle, Erik A, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
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Published in Journal of medicinal chemistry (24.05.2018)
Published in Journal of medicinal chemistry (24.05.2018)
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Piperazine azaspiro derivatives
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