Choline Kinase Emerges as a Promising Drug Target in Gram-Positive Bacteria
Zimmerman, Tahl, Lacal, Juan Carlos, Ibrahim, Salam A.
Published in Frontiers in microbiology (15.10.2019)
Published in Frontiers in microbiology (15.10.2019)
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Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment
Gallego-Ortega, David, Ramirez de Molina, Ana, Ramos, Maria Angeles, Valdes-Mora, Fatima, Barderas, Maria Gonzalez, Sarmentero-Estrada, Jacinto, Lacal, Juan Carlos
Published in PloS one (12.11.2009)
Published in PloS one (12.11.2009)
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Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma
Marien, Eyra, Meister, Michael, Muley, Thomas, Gomez Del Pulgar, Teresa, Derua, Rita, Spraggins, Jeffrey M, Van de Plas, Raf, Vanderhoydonc, Frank, Machiels, Jelle, Binda, Maria Mercedes, Dehairs, Jonas, Willette-Brown, Jami, Hu, Yinling, Dienemann, Hendrik, Thomas, Michael, Schnabel, Philipp A, Caprioli, Richard M, Lacal, Juan Carlos, Waelkens, Etienne, Swinnen, Johannes V
Published in Oncotarget (15.03.2016)
Published in Oncotarget (15.03.2016)
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Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts
de la Cueva, Ana, Ramírez de Molina, Ana, Alvarez-Ayerza, Néstor, Ramos, Ma Angeles, Cebrián, Arancha, Del Pulgar, Teresa Gómez, Lacal, Juan Carlos
Published in PloS one (10.06.2013)
Published in PloS one (10.06.2013)
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Orthotopic Microinjection of Human Colon Cancer Cells in Nude Mice Induces Tumor Foci in All Clinically Relevant Metastatic Sites
Céspedes, María Virtudes, Espina, Carolina, García-Cabezas, Miguel Angel, Trias, Manuel, Boluda, Alicia, Gómez del Pulgar, María Teresa, Sancho, Francesc Josep, Nistal, Manuel, Lacal, Juan Carlos, Mangues, Ramon
Published in The American journal of pathology (01.03.2007)
Published in The American journal of pathology (01.03.2007)
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Journal Article
Antiplasmodial Activity and Mechanism of Action of RSM-932A, a Promising Synergistic Inhibitor of Plasmodium falciparum Choline Kinase
ZIMMERMAN, Tahl, MONERIZ, Carlos, DIEZ, Amalia, BAUTISTA, José Manuel, DEL PULGAR, Teresa Gómez, CEBRIAN, Arancha, LACAL, Juan Carlos
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer
Valdés-Mora, Fatima, Locke, Warwick J, Bandrés, Eva, Gallego-Ortega, David, Cejas, Paloma, García-Cabezas, Miguel Angel, Colino-Sanguino, Yolanda, Feliú, Jaime, Del Pulgar, Teresa Gómez, Lacal, Juan Carlos
Published in Oncotarget (18.04.2017)
Published in Oncotarget (18.04.2017)
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Journal Article
Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy
RAMIREZ DE MOLINA, Ana, GUTIERREZ, Ruth, RAMOS, Maria Angeles, SILVA, José Maria, SILVA, Javier, BONILLA, Félix, SANCHEZ, José Javier, LACAL, Juan Carlos
Published in Oncogene (20.06.2002)
Published in Oncogene (20.06.2002)
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Journal Article
Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production
Sanchez-Lopez, Elsa, Zhong, Zhenyu, Stubelius, Alexandra, Sweeney, Shannon R., Booshehri, Laela M., Antonucci, Laura, Liu-Bryan, Ru, Lodi, Alessia, Terkeltaub, Robert, Lacal, Juan Carlos, Murphy, Anne N., Hoffman, Hal M., Tiziani, Stefano, Guma, Monica, Karin, Michael
Published in Cell metabolism (04.06.2019)
Published in Cell metabolism (04.06.2019)
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Differential expression of Rac1 identifies its target genes and its contribution to progression of colorectal cancer
Gómez del Pulgar, Teresa, Bandrés, Eva, Espina, Carolina, Valdés-Mora, Fátima, Pérez-Palacios, Rosa, García-Amigot, Fermín, García-Foncillas, Jesús, Lacal, Juan Carlos
Published in The international journal of biochemistry & cell biology (2007)
Published in The international journal of biochemistry & cell biology (2007)
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Sensitization of (colon) cancer cells to death receptor related therapies: A report from the FP6-ONCODEATH research consortium
Pintzas, Alexander, Zhivotovsky, Boris, Workman, Paul, Clarke, Paul A., Linardopoulos, Spiros, Martinou, Jean-Claude, Lacal, Juan Carlos, Robine, Sylvie, Nasioulas, George, Andera, Ladislav
Published in Cancer biology & therapy (01.05.2012)
Published in Cancer biology & therapy (01.05.2012)
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Journal Article
Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway
ESTEVE, P, EMBADE, N, PERONA, R, JIMENEZ, B, DEL PESO, L, LEON, J, ARENDS, M, MIKI, T, LACAL, J. C
Published in Oncogene (08.10.1998)
Published in Oncogene (08.10.1998)
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Protein chimerism: Novel source of protein diversity in humans adds complexity to bottom-up proteomics
Casado-Vela, Juan, Lacal, Juan Carlos, Elortza, Felix
Published in Proteomics (Weinheim) (01.01.2013)
Published in Proteomics (Weinheim) (01.01.2013)
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Journal Article
Rho GTPase expression in tumourigenesis: Evidence for a significant link
del Pulgar, Teresa Gómez, Benitah, Salvador A., Valerón, Pilar F., Espina, Carolina, Lacal, Juan Carlos
Published in BioEssays (01.06.2005)
Published in BioEssays (01.06.2005)
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Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study
de Molina, Ana Ramírez, PhD, Sarmentero-Estrada, Jacinto, MSc, Belda-Iniesta, Cristóbal, MD, Tarón, Miquel, PhD, de Molina, Victor Ramírez, MD, Cejas, Paloma, PhD, Skrzypski, Marcin, MD, Gallego-Ortega, David, MSc, de Castro, Javier, MD, Casado, Enrique, MD, García-Cabezas, Miguel Angel, PhD, Sánchez, Jose Javier, Prof, Nistal, Manuel, Prof, Rosell, Rafael, Prof, González-Barón, Manuel, Prof, Lacal, Juan Carlos, Prof
Published in The lancet oncology (01.10.2007)
Published in The lancet oncology (01.10.2007)
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Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers
Ramı́rez de Molina, Ana, Rodrı́guez-González, Agustı́n, Gutiérrez, Ruth, Martı́nez-Piñeiro, Luis, Sánchez, José J, Bonilla, Félix, Rosell, Rafael, Lacal, Juan Carlos
Published in Biochemical and biophysical research communications (23.08.2002)
Published in Biochemical and biophysical research communications (23.08.2002)
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