RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients
Venken, Koen, Jacques, Peggy, Mortier, Céline, Labadia, Mark E, Decruy, Tine, Coudenys, Julie, Hoyt, Kathleen, Wayne, Anita L, Hughes, Robert, Turner, Michael, Van Gassen, Sofie, Martens, Liesbet, Smith, Dustin, Harcken, Christian, Wahle, Joseph, Wang, Chao-Ting, Verheugen, Eveline, Schryvers, Nadia, Varkas, Gaëlle, Cypers, Heleen, Wittoek, Ruth, Piette, Yves, Gyselbrecht, Lieve, Van Calenbergh, Serge, Van den Bosch, Filip, Saeys, Yvan, Nabozny, Gerald, Elewaut, Dirk
Published in Nature communications (02.01.2019)
Published in Nature communications (02.01.2019)
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Journal Article
Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors
Li, Xiang, Anderson, Marie, Collin, Delphine, Muegge, Ingo, Wan, John, Brennan, Debra, Kugler, Stanley, Terenzio, Donna, Kennedy, Charles, Lin, Siqi, Labadia, Mark E., Cook, Brian, Hughes, Robert, Farrow, Neil A.
Published in The Journal of biological chemistry (14.07.2017)
Published in The Journal of biological chemistry (14.07.2017)
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Journal Article
Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats
van Tok, Melissa N, Mandour, Mohamed, Wahle, Joseph, Labadia, Mark E, van de Sande, Marleen G H, Nabozny, Gerald, Baeten, Dominique L, van Duivenvoorde, Leonie M
Published in Frontiers in immunology (06.09.2021)
Published in Frontiers in immunology (06.09.2021)
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Journal Article
Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORγt
Yang, Jianfei, Yang, Min, Htut, Tin Min, Ouyang, Xinshou, Hanidu, Adedayo, Li, Xiang, Sellati, Rosemarie, Jiang, Huiping, Zhang, Shu, Li, Hongxing, Zhao, Jie, Ting, Adrian T, Mayer, Lloyd, Unkeless, Jay C, Labadia, Mark E, Hodge, Martin, Li, Jun, Xiong, Huabao
Published in European journal of immunology (01.05.2008)
Published in European journal of immunology (01.05.2008)
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Journal Article
An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients
Bassolas-Molina, Helena, Raymond, Ernest, Labadia, Mark, Wahle, Joseph, Ferrer-Picón, Elena, Panzenbeck, Mark, Zheng, Jie, Harcken, Christian, Hughes, Robert, Turner, Michael, Smith, Dustin, Calderón-Gómez, Elisabeth, Esteller, Míriam, Carrasco, Anna, Esteve, Maria, Dotti, Isabella, Corraliza, Ana Maria, Masamunt, Maria Carme, Arajol, Clàudia, Guardiola, Jordi, Ricart, Elena, Nabozny, Gerald, Salas, Azucena
Published in Frontiers in immunology (22.10.2018)
Published in Frontiers in immunology (22.10.2018)
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Journal Article
Pathogenic mechanisms and experimental models of multiple sclerosis
Slavin, Anthony, Kelly-Modis, Louise, Labadia, Mark, Ryan, Kelli, Brown, Maryanne L.
Published in Autoimmunity (Chur, Switzerland) (01.11.2010)
Published in Autoimmunity (Chur, Switzerland) (01.11.2010)
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Journal Article
Involvement of GATA3 in Protein Kinase C θ‐induced Th2 cytokine expression
Stevens, Lisa, Htut, Tin M., White, Della, Li, Xiang, Hanidu, Adedayo, Stearns, Carol, Labadia, Mark E., Li, Jun, Brown, Maryanne, Yang, Jianfei
Published in European journal of immunology (01.12.2006)
Published in European journal of immunology (01.12.2006)
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Journal Article
Discovery and Characterization of a Substrate Selective p38α Inhibitor
Davidson, Walter, Frego, Lee, Peet, Gregory W, Kroe, Rachel R, Labadia, Mark E, Lukas, Susan M, Snow, Roger J, Jakes, Scott, Grygon, Christine A, Pargellis, Christopher, Werneburg, Brian G
Published in Biochemistry (Easton) (21.09.2004)
Published in Biochemistry (Easton) (21.09.2004)
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Journal Article
High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization
Pullen, Steven S, Labadia, Mark E, Ingraham, Richard H, McWhirter, Sarah M, Everdeen, Daniel S, Alber, Tom, Crute, James J, Kehry, Marilyn R
Published in Biochemistry (Easton) (03.08.1999)
Published in Biochemistry (Easton) (03.08.1999)
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Journal Article
Catalysis and Function of the p38α·MK2a Signaling Complex
Lukas, Susan M, Kroe, Rachel R, Wildeson, Jessi, Peet, Gregory W, Frego, Lee, Davidson, Walter, Ingraham, Richard H, Pargellis, Christopher A, Labadia, Mark E, Werneburg, Brian G
Published in Biochemistry (Easton) (10.08.2004)
Published in Biochemistry (Easton) (10.08.2004)
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Journal Article
Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors
Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
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Journal Article
The determination and correlation of molecular and cellular equilibrium Kd and kinetic koff values for small molecule allosteric antagonists of LFA-1
CAUINESS, Gary O, LABADIA, Mark E, GIBLIN, Patricia A, WOSKA, Joseph R, LAST-BARNEY, Kathleen, JEANFAVRE, Deborah D, MORELOCK, Maurice M
Published in Biochemical pharmacology (30.06.2007)
Published in Biochemical pharmacology (30.06.2007)
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Journal Article
Agonist versus antagonist induce distinct thermodynamic modes of co-factor binding to the glucocorticoid receptor
Kroe, Rachel R., Baker, Martha A., Brown, Martha P., Farrow, Neil A., Gautschi, Elda, Hopkins, Jerry L., LaFrance, Roger R., Kronkaitis, Anthony, Freeman, Dorothy, Thomson, David, Nabozny, Gerald, Grygon, Christine A., Labadia, Mark E.
Published in Biophysical chemistry (01.07.2007)
Published in Biophysical chemistry (01.07.2007)
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Journal Article
Molecular Regulation of the Interaction Between Leukocyte Function-Associated Antigen-1 and Soluble ICAM-1 by Divalent Metal Cations
Labadia, Mark E, Jeanfavre, Deborah Durham, Caviness, Gary O, Morelock, Maurice M
Published in The Journal of immunology (1950) (15.07.1998)
Published in The Journal of immunology (1950) (15.07.1998)
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Journal Article
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors
Bekkali, Younes, Thomson, David S., Betageri, Raj, Emmanuel, Michel J., Hao, Ming-Hong, Hickey, Eugene, Liu, Weimin, Patel, Usha, Ward, Yancey D., Young, Erick R.R., Nelson, Richard, Kukulka, Alison, Brown, Maryanne L., Crane, Kathy, White, Della, Freeman, Dorothy M., Labadia, Mark E., Wildeson, Jessi, Spero, Denice M.
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
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Journal Article
Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor
Merluzzi, Vincent J., Hargrave, Karl D., Labadia, Mark, Grozinger, Karl, Skoog, Mark, Wu, Joseph C., Shih, Cheng-Kon, Eckner, Kristine, Hattox, Susan, Adams, Julian, Rosehthal, Alan S., Faanes, Ronald, Eckner, Robert J., Koup, Richard A., Sullivan, John L.
Published in Science (American Association for the Advancement of Science) (07.12.1990)
Published in Science (American Association for the Advancement of Science) (07.12.1990)
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Journal Article
The design of potent hydrazones and disulfides as cathepsin S inhibitors
Cywin, Charles L, Firestone, Raymond A, McNeil, Daniel W, Grygon, Christine A, Crane, Kathryn M, White, Della M, Kinkade, Peter R, Hopkins, Jerry L, Davidson, Walter, Labadia, Mark E, Wildeson, Jessi, Morelock, Maurice M, Peterson, Jeffrey D, Raymond, Ernest L, Brown, Maryanne L, Spero, Denice M
Published in Bioorganic & medicinal chemistry (06.03.2003)
Published in Bioorganic & medicinal chemistry (06.03.2003)
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Journal Article
Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors
Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Girardot, Marc, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M
Published in Journal of medicinal chemistry (27.02.2003)
Published in Journal of medicinal chemistry (27.02.2003)
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Journal Article
Discovery of 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide analogs as new RORC modulators
Muegge, Ingo, Collin, Delphine, Cook, Brian, Hill-Drzewi, Melissa, Horan, Josh, Kugler, Stanley, Labadia, Mark, Li, Xiang, Smith, Lana, Zhang, Yunlong
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
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Journal Article
Discovery of a Series of Pyrazinone RORγ Antagonists and Identification of the Clinical Candidate BI 730357
Harcken, Christian, Csengery, Johanna, Turner, Michael, Wu, Lifen, Liang, Shuang, Sibley, Robert, Brunette, Steven, Labadia, Mark, Hoyt, Kathleen, Wayne, Anita, Wieckowski, Thomas, Davis, Gregg, Panzenbeck, Mark, Souza, Donald, Kugler, Stanley, Terenzio, Donna, Collin, Delphine, Smith, Dustin, Fryer, Ryan M, Tseng, Yin-Chao, Hehn, Jörg P, Fletcher, Kim, Hughes, Robert O
Published in ACS medicinal chemistry letters (14.01.2021)
Published in ACS medicinal chemistry letters (14.01.2021)
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