Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition
LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Wang, Ping, Stams, Travis, LaMarche, Matthew J., Chopra, Rajiv, Acker, Michael G., Blacklow, Stephen C.
Published in Nature communications (30.10.2018)
Published in Nature communications (30.10.2018)
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Journal Article
Fluorescence Correlation Spectroscopy Reveals Highly Efficient Cytosolic Delivery of Certain Penta-Arg Proteins and Stapled Peptides
LaRochelle, Jonathan R, Cobb, Garrett B, Steinauer, Angela, Rhoades, Elizabeth, Schepartz, Alanna
Published in Journal of the American Chemical Society (25.02.2015)
Published in Journal of the American Chemical Society (25.02.2015)
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Journal Article
Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery
Qian, Ziqing, LaRochelle, Jonathan R, Jiang, Bisheng, Lian, Wenlong, Hard, Ryan L, Selner, Nicholas G, Luechapanichkul, Rinrada, Barrios, Amy M, Pei, Dehua
Published in Biochemistry (Easton) (24.06.2014)
Published in Biochemistry (Easton) (24.06.2014)
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Journal Article
Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2
LaRochelle, Jonathan R, Fodor, Michelle, Xu, Xiang, Durzynska, Izabela, Fan, Lixin, Stams, Travis, Chan, Ho Man, LaMarche, Matthew J, Chopra, Rajiv, Wang, Ping, Fortin, Pascal D, Acker, Michael G, Blacklow, Stephen C
Published in Biochemistry (Easton) (19.04.2016)
Published in Biochemistry (Easton) (19.04.2016)
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Journal Article
Improved Rapid Equilibrium Dialysis-Mass Spectrometry (RED-MS) Method for Measuring Small Molecule–Protein Complex Binding Affinities in Solution
Choi, Bryan, Han, Calvin, LaRochelle, Jonathan R., Pitsawong, Warintra, Houde, Damian
Published in Journal of the American Society for Mass Spectrometry (04.11.2024)
Published in Journal of the American Society for Mass Spectrometry (04.11.2024)
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Journal Article
HOPS-dependent endosomal fusion required for efficient cytosolic delivery of therapeutic peptides and small proteins
Steinauer, Angela, LaRochelle, Jonathan R., Knox, Susan L., Wissner, Rebecca F., Berry, Samuel, Schepartz, Alanna
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2019)
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Journal Article
Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo
Li, Margie, Tao, Yong, Shu, Yilai, LaRochelle, Jonathan R, Steinauer, Angela, Thompson, David, Schepartz, Alanna, Chen, Zheng-Yi, Liu, David R
Published in Journal of the American Chemical Society (11.11.2015)
Published in Journal of the American Chemical Society (11.11.2015)
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Journal Article
Dual Allosteric Inhibition of SHP2 Phosphatase
Fodor, Michelle, Price, Edmund, Wang, Ping, Lu, Hengyu, Argintaru, Andreea, Chen, Zhouliang, Glick, Meir, Hao, Huai-Xiang, Kato, Mitsunori, Koenig, Robert, LaRochelle, Jonathan R, Liu, Gang, McNeill, Eric, Majumdar, Dyuti, Nishiguchi, Gisele A, Perez, Lawrence B, Paris, Gregory, Quinn, Christopher M, Ramsey, Timothy, Sendzik, Martin, Shultz, Michael David, Williams, Sarah L, Stams, Travis, Blacklow, Stephen C, Acker, Michael G, LaMarche, Matthew J
Published in ACS chemical biology (16.03.2018)
Published in ACS chemical biology (16.03.2018)
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Journal Article
Improved Assays for Determining the Cytosolic Access of Peptides, Proteins, and Their Mimetics
Holub, Justin M, LaRochelle, Jonathan R, Appelbaum, Jacob S, Schepartz, Alanna
Published in Biochemistry (Easton) (17.12.2013)
Published in Biochemistry (Easton) (17.12.2013)
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Journal Article
Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2
LaRochelle, Jonathan R., Fodor, Michelle, Ellegast, Jana M., Liu, Xiaoxi, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Stams, Travis, Buhrlage, Sara J., Stegmaier, Kimberly, LaMarche, Matthew J., Acker, Michael G., Blacklow, Stephen C.
Published in Bioorganic & medicinal chemistry (15.12.2017)
Published in Bioorganic & medicinal chemistry (15.12.2017)
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Journal Article
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia
Varkaris, Andreas, Pazolli, Ermira, Gunaydin, Hakan, Wang, Qi, Pierce, Levi, Boezio, Alessandro A, Bulku, Artemisa, DiPietro, Lucian, Fridrich, Cary, Frost, Adam, Giordanetto, Fabrizio, Hamilton, Erika P, Harris, Katherine, Holliday, Michael, Hunter, Tamieka L, Iskandar, Amanda, Ji, Yongli, Larivée, Alexandre, LaRochelle, Jonathan R, Lescarbeau, André, Llambi, Fabien, Lormil, Brenda, Mader, Mary M, Mar, Brenton G, Martin, Iain, McLean, Thomas H, Michelsen, Klaus, Pechersky, Yakov, Puente-Poushnejad, Erika, Raynor, Kevin, Rogala, Dipali, Samadani, Ramin, Schram, Alison M, Shortsleeves, Kelley, Swaminathan, Sweta, Tajmir, Shahein, Tan, Gege, Tang, Yong, Valverde, Roberto, Wehrenberg, Bryan, Wilbur, Jeremy, Williams, Bret R, Zeng, Hongtao, Zhang, Hanmo, Walters, W Patrick, Wolf, Beni B, Shaw, David E, Bergstrom, Donald A, Watters, James, Fraser, James S, Fortin, Pascal D, Kipp, D Randal
Published in Cancer discovery (08.02.2024)
Published in Cancer discovery (08.02.2024)
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Journal Article
Abstract 2808: Simultaneous inhibition of SHP2 phosphatase at two allosteric sites
Fodor, Michelle, Price, Edmund, Wang, Ping, Lu, Hengyu, Argintaru, Andreea, Chen, Zhouliang, Glick, Meir, Hao, Huai-Xiang, Kato, Mitsunori, Koenig, Robert, LaRochelle, Jonathan R., Liu, Gang, McNeill, Eric, Majumdar, Dyuti, Nishiguchi, Gisele, Perez, Lawrence, Paris, Greg, Quinn, Christopher, Ramsey, Timothy, Sendzik, Martin, Shultz, Michael, Williams, Sarah, Stams, Travis, Blacklow, Stephen C., LaMarche, Matthew J., Acker, Michael G.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2
LaRochelle, Jonathan R., Fodor, Michelle, Ellegast, Jana M., Liu, Xiaoxi, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Stams, Travis, Buhrlage, Sara J., Stegmaier, Kimberly, LaMarche, Matthew J., Acker, Michael G., Blacklow, Stephen C.
Published in Bioorganic & medicinal chemistry (01.12.2017)
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Published in Bioorganic & medicinal chemistry (01.12.2017)
Journal Article
Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers
Acker, Michael G., Chen, Ying-Nan P., LaMarche, Matthew J., Chan, Ho Man, Fekkes, Peter, Garcia-Fortanet, Jorge, LaRochelle, Jonathan R., Antonakos, Brandon, Chen, Christine Hiu-Tung, Chen, Zhuoliang, Cooke, Vesselina G., Dobson, Jason R., Deng, Zhan, Feng, Fei, Firestone, Brant, Fodor, Michelle, Fridrich, Cary, Gao, Hui, Hao, Huai-Xiang, Jacob, Jaison, Ho, Samuel, Hsiao, Kathy, Kang, Zhao B., Karki, Rajesh, Kato, Mitsunori, Larrow, Jay, Bonte, Laura R. La, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Meyer, Matthew J., Palermo, Mark, Pu, Minying, Price, Edmund, Shakya, Subarna, Shultz, Michael D., Venkatesan, Kavitha, Wang, Ping, Warmuth, Markus, Williams, Sarah, Yang, Guizhi, Yuan, Jing, Zhang, Ji-Hu, Zhu, Ping, Blacklow, Stephen C., Ramsey, Timothy, Keen, Nicholas J., Sellers, William R., Stams, Travis, Fortin, Pascal D.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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