Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel
LaFavers, Kaice A, Macedo, Etienne, Garimella, Pranav S, Lima, Camila, Khan, Shehnaz, Myslinski, Jered, McClintick, Jeanette, Witzmann, Frank A, Winfree, Seth, Phillips, Carrie L, Hato, Takashi, Dagher, Pierre C, Wu, Xue-Ru, El-Achkar, Tarek M, Micanovic, Radmila
Published in Science translational medicine (02.10.2019)
Published in Science translational medicine (02.10.2019)
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A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease
Canela, Victor Hugo, Bowen, William S, Ferreira, Ricardo Melo, Syed, Farooq, Lingeman, James E, Sabo, Angela R, Barwinska, Daria, Winfree, Seth, Lake, Blue B, Cheng, Ying-Hua, Gaut, Joseph P, Ferkowicz, Michael, LaFavers, Kaice A, Zhang, Kun, Coe, Fredric L, Worcester, Elaine, Jain, Sanjay, Eadon, Michael T, Williams, Jr, James C, El-Achkar, Tarek M
Published in Nature communications (19.07.2023)
Published in Nature communications (19.07.2023)
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Journal Article
The kidney protects against sepsis by producing systemic uromodulin
LaFavers, Kaice A, Hage, Chadi A, Gaur, Varun, Micanovic, Radmila, Hato, Takashi, Khan, Shehnaz, Winfree, Seth, Doshi, Simit, Moorthi, Ranjani N, Twigg, Homer, Wu, Xue-Ru, Dagher, Pierre C, Srour, Edward F, El-Achkar, Tarek M
Published in American journal of physiology. Renal physiology (01.08.2022)
Published in American journal of physiology. Renal physiology (01.08.2022)
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Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii
Varberg, Joseph M, LaFavers, Kaice A, Arrizabalaga, Gustavo, Sullivan, Jr, William J
Published in Antimicrobial agents and chemotherapy (01.02.2018)
Published in Antimicrobial agents and chemotherapy (01.02.2018)
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Journal Article
The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain
Micanovic, Radmila, LaFavers, Kaice A, Patidar, Kavish R, Ghabril, Marwan S, Doud, Emma H, Mosley, Amber L, Sabo, Angela R, Khan, Shehnaz, El-Achkar, Tarek M
Published in American journal of physiology. Renal physiology (01.04.2022)
Published in American journal of physiology. Renal physiology (01.04.2022)
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Journal Article
Water Loading and Uromodulin Secretion in Healthy Individuals and Idiopathic Calcium Stone Formers
LaFavers, Kaice A, Gaddy, Anna R, Micanovic, Radmila, Lingeman, James, Williams, Jr, James C, Coe, Fredric L, El-Achkar, Tarek M, Worcester, Elaine
Published in Clinical journal of the American Society of Nephrology (01.08.2023)
Published in Clinical journal of the American Society of Nephrology (01.08.2023)
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Journal Article
Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes
Mansour, Sherry G, Liu, Caroline, Jia, Yaqi, Reese, Peter P, Hall, Isaac E, El-Achkar, Tarek M, LaFavers, Kaice A, Obeid, Wassim, Rosenberg, Avi Z, Daneshpajouhnejad, Parnaz, Doshi, Mona D, Akalin, Enver, Bromberg, Jonathan S, Harhay, Meera N, Mohan, Sumit, Muthukumar, Thangamani, Schröppel, Bernd, Singh, Pooja, El-Khoury, Joe M, Weng, Francis L, Thiessen-Philbrook, Heather R, Parikh, Chirag R
Published in Transplantation (01.04.2021)
Published in Transplantation (01.04.2021)
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Inhibition of Apurinic/Apyrimidinic Endonuclease I’s Redox Activity Revisited
Zhang, Jun, Luo, Meihua, Marasco, Daniela, Logsdon, Derek, LaFavers, Kaice A, Chen, Qiujia, Reed, April, Kelley, Mark R, Gross, Michael L, Georgiadis, Millie M
Published in Biochemistry (Easton) (30.04.2013)
Published in Biochemistry (Easton) (30.04.2013)
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Journal Article
Myeloid Cell Deletion of the Cationic Channel TRPM2, a Target of Uromodulin Inhibition, Is Protective in Murine Sepsis: SA-PO183
LaFavers, Kaice A., Sabo, Angela R., Rhodes, George, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.11.2023)
Published in Journal of the American Society of Nephrology (01.11.2023)
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Journal Article
Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene: FR-PO841
Nanamatsu, Azuma, Micanovic, Radmila, Khan, Shehnaz, El-Achkar, Tarek M., LaFavers, Kaice A.
Published in Journal of the American Society of Nephrology (01.11.2023)
Published in Journal of the American Society of Nephrology (01.11.2023)
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Uromodulin Deficiency Shapes AKI Severity by Enhanced Oxidative Injury and Stress Response in Proximal Tubules With Early Activation of the Inflammasome: FR-PO150
LaFavers, Kaice A., Micanovic, Radmila, Sabo, Angela R., Khan, Shehnaz, Winfree, Seth, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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Journal Article
The Kidney Produces a Non-Polymerizing Form of Uromodulin That Associates with Reduced Risk of AKI: PO0419
Micanovic, Radmila, LaFavers, Kaice A., Patidar, Kavish R., Khan, Shehnaz, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.10.2021)
Published in Journal of the American Society of Nephrology (01.10.2021)
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Journal Article
Alternative Splicing Generates an Intracellular Uromodulin Isoform that Mediates Mitochondrial Function and Is Up-Regulated in AKI: FR-PO184
Nanamatsu, Azuma, LaFavers, Kaice A., Micanovic, Radmila, Lazar, Virginie, Rhodes, George, Khan, Shehnaz, Bacallao, Robert L., Dagher, Pierre C., Hato, Takashi, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.11.2023)
Published in Journal of the American Society of Nephrology (01.11.2023)
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Transcriptomic Profiling of Thick Ascending Limb Cells In Vivo Reveals the Complex Network of Genes Regulated by Uromodulin: PO0629
LaFavers, Kaice A., Khan, Shehnaz, Khan, Nida A., Apple, Laura, Micanovic, Radmila, El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
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Journal Article
Uromodulin and Injury Severity Alter Neutrophil Diversity and Signaling in AKI: FR-PO154
Winfree, Seth, LaFavers, Kaice A., Khan, Shehnaz, Micanovic, Radmila, ferreira, Ricardo Melo, Cheng, Ying-Hua, Eadon, Michael T., El-Achkar, Tarek M.
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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