APOE genotype alters glial activation and loss of synaptic markers in mice
Zhu, Yuangui, Nwabuisi-Heath, Evelyn, Dumanis, Sonya B., Tai, Leon M., Yu, Chunjiang, Rebeck, G. William, Ladu, Mary Jo
Published in Glia (01.04.2012)
Published in Glia (01.04.2012)
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Journal Article
Rexinoids as Therapeutics for Alzheimer's Disease: Role of APOE
Koster, Kevin P, Smith, Conor, Valencia-Olvera, Ana C, Thatcher, Gregory R J, Tai, Leon M, LaDu, Mary Jo
Published in Current topics in medicinal chemistry (01.01.2017)
Published in Current topics in medicinal chemistry (01.01.2017)
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Genetics ignite focus on microglial inflammation in Alzheimer's disease
Malik, Manasi, Parikh, Ishita, Vasquez, Jared B, Smith, Conor, Tai, Leon, Bu, Guojun, LaDu, Mary Jo, Fardo, David W, Rebeck, G William, Estus, Steven
Published in Molecular neurodegeneration (05.10.2015)
Published in Molecular neurodegeneration (05.10.2015)
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Journal Article
Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease
Lewis, Terry L., Cao, Dongfeng, Lu, Hailin, Mans, Robert A., Su, Yan Ru, Jungbauer, Lisa, Linton, MacRae F., Fazio, Sergio, LaDu, Mary Jo, Li, Ling
Published in The Journal of biological chemistry (19.11.2010)
Published in The Journal of biological chemistry (19.11.2010)
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Journal Article
Murine Gut Microbiome Association With APOE Alleles
Parikh, Ishita J, Estus, Janice L, Zajac, Diana J, Malik, Manasi, Maldonado Weng, Juan, Tai, Leon M, Chlipala, George E, LaDu, Mary Jo, Green, Stefan J, Estus, Steven
Published in Frontiers in immunology (14.02.2020)
Published in Frontiers in immunology (14.02.2020)
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Journal Article
APOE genotype and sex modulate Alzheimer's disease pathology in aged EFAD transgenic mice
Balu, Deebika, Valencia-Olvera, Ana C, Islam, Zarak, Mielczarek, Clare, Hansen, Allison, Perez Ramos, Tamara M, York, Jason, LaDu, Mary Jo, Tai, Leon M
Published in Frontiers in aging neuroscience (31.10.2023)
Published in Frontiers in aging neuroscience (31.10.2023)
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Journal Article
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
Balu, Deebika, Valencia-Olvera, Ana C, Nguyen, Austin, Patnam, Mehul, York, Jason, Peri, Francesco, Neumann, Frank, LaDu, Mary Jo, Tai, Leon M
Published in Alzheimer's research & therapy (19.10.2023)
Published in Alzheimer's research & therapy (19.10.2023)
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Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease
Ma, Qiu-Lan, Teng, Edmond, Zuo, Xiaohong, Jones, Mychica, Teter, Bruce, Zhao, Evan Y., Zhu, Cansheng, Bilousova, Tina, Gylys, Karen H., Apostolova, Liana G., LaDu, Mary Jo, Hossain, Mir Ahamed, Frautschy, Sally A., Cole, Gregory M.
Published in Neurobiology of disease (01.06.2018)
Published in Neurobiology of disease (01.06.2018)
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Journal Article
A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
Valencia-Olvera, Ana C, Balu, Deebika, Bellur, Shreya, McNally, Thomas, Saleh, Yaseen, Pham, Don, Ghura, Shivesh, York, Jason, Johansson, Jan O, LaDu, Mary Jo, Tai, Leon
Published in Alzheimer's research & therapy (15.12.2023)
Published in Alzheimer's research & therapy (15.12.2023)
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Journal Article
Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking
Fuentealba, Rodrigo A., Liu, Qiang, Zhang, Juan, Kanekiyo, Takahisa, Hu, Xiaoyan, Lee, Jin-Moo, LaDu, Mary Jo, Bu, Guojun
Published in PloS one (29.07.2010)
Published in PloS one (29.07.2010)
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Estradiol improves behavior in FAD transgenic mice that express APOE3 but not APOE4 after ovariectomy
Balu, Deebika, Valencia-Olvera, Ana C, Deshpande, Ashwini, Narayanam, Saharsh, Konasani, Sravya, Pattisapu, Shreya, York, Jason M, Thatcher, Gregory R J, LaDu, Mary Jo, Tai, Leon M
Published in Frontiers in endocrinology (Lausanne) (29.04.2024)
Published in Frontiers in endocrinology (Lausanne) (29.04.2024)
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Journal Article
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Youmans, Katherine L, Tai, Leon M, Kanekiyo, Takahisa, Stine, Jr, W Blaine, Michon, Sara-Claude, Nwabuisi-Heath, Evelyn, Manelli, Arlene M, Fu, Yifan, Riordan, Sean, Eimer, William A, Binder, Lester, Bu, Guojun, Yu, Chunjiang, Hartley, Dean M, LaDu, Mary Jo
Published in Molecular neurodegeneration (16.03.2012)
Published in Molecular neurodegeneration (16.03.2012)
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Journal Article
APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice
Zhou, Meng, Huang, Tianwen, Collins, Nicole, Zhang, Jing, Shen, Hui, Dai, Xiaoman, Xiao, Naian, Wu, Xilin, Wei, Zhen, York, Jason, Lin, Lanyan, Zhu, Yuangui, LaDu, Mary Jo, Chen, Xiaochun
Published in Current Alzheimer research (01.01.2016)
Published in Current Alzheimer research (01.01.2016)
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Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
Lewandowski, Cutler T., Khan, Md.Wasim, BenAissa, Manel, Dubrovskyi, Oleksii, Ackerman-Berrier, Martha, LaDu, Mary Jo, Layden, Brian T., Thatcher, Gregory R.J.
Published in EBioMedicine (01.04.2021)
Published in EBioMedicine (01.04.2021)
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Journal Article
EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimerʼns disease[S]
Tai, Leon M., Balu, Deebika, Avila-Munoz, Evangelina, Abdullah, Laila, Thomas, Riya, Collins, Nicole, Valencia-Olvera, Ana Carolina, LaDu, Mary Jo
Published in Journal of lipid research (01.09.2017)
Published in Journal of lipid research (01.09.2017)
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Journal Article
Cellular Catabolism of Lipid Poor Apolipoprotein E via Cell Surface LDL Receptor-Related Protein
Narita, Masaaki, Holtzman, David M., Fagan, Anne M., LaDu, Mary Jo, Yu, Li, Han, Xianlin, Gross, Richard W., Bu, Guojun, Schwartz, Alan L.
Published in Journal of biochemistry (Tokyo) (01.11.2002)
Published in Journal of biochemistry (Tokyo) (01.11.2002)
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Journal Article
ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro
Nwabuisi-Heath, Evelyn, Rebeck, G William, Ladu, Mary Jo, Yu, Chunjiang
Published in ASN neuro (13.01.2014)
Published in ASN neuro (13.01.2014)
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