Histone demethylase KDM5D upregulation drives sex differences in colon cancer
Li, Jiexi, Lan, Zhengdao, Liao, Wenting, Horner, James W., Xu, Xueping, Liu, Jielin, Yoshihama, Yohei, Jiang, Shan, Shim, Hong Seok, Slotnik, Max, LaBella, Kyle A., Wu, Chang-Jiun, Dunner, Kenneth, Hsu, Wen-Hao, Lee, Rumi, Khanduri, Isha, Terranova, Christopher, Akdemir, Kadir, Chakravarti, Deepavali, Shang, Xiaoying, Spring, Denise J., Wang, Y. Alan, DePinho, Ronald A.
Published in Nature (London) (20.07.2023)
Published in Nature (London) (20.07.2023)
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Journal Article
Quantitative intravital imaging in zebrafish reveals in vivo dynamics of physiological-stress-induced mitophagy
Wrighton, Paul J, Shwartz, Arkadi, Heo, Jin-Mi, Quenzer, Eleanor D, LaBella, Kyle A, Harper, J Wade, Goessling, Wolfram
Published in Journal of cell science (22.02.2021)
Published in Journal of cell science (22.02.2021)
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Journal Article
Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
Han, Jincheng, Xu, Jiaqian, Liu, Yonghong, Liang, Shaoheng, LaBella, Kyle A, Chakravarti, Deepavali, Spring, Denise J, Xia, Yan, DePinho, Ronald A
Published in Genes & development (01.09.2023)
Published in Genes & development (01.09.2023)
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Journal Article
Telomere dysfunction activates YAP1 to drive tissue inflammation
Chakravarti, Deepavali, Hu, Baoli, Mao, Xizeng, Rashid, Asif, Li, Jiexi, Li, Jun, Liao, Wen-ting, Whitley, Elizabeth M., Dey, Prasenjit, Hou, Pingping, LaBella, Kyle A., Chang, Andrew, Wang, Guocan, Spring, Denise J., Deng, Pingna, Zhao, Di, Liang, Xin, Lan, Zhengdao, Lin, Yiyun, Sarkar, Sharmistha, Terranova, Christopher, Deribe, Yonathan Lissanu, Blutt, Sarah E., Okhuysen, Pablo, Zhang, Jianhua, Vilar, Eduardo, Nielsen, Ole Haagen, Dupont, Andrew, Younes, Mamoun, Patel, Kalyani R., Shroyer, Noah F., Rai, Kunal, Estes, Mary K., Wang, Y. Alan, Bertuch, Alison A., DePinho, Ronald A.
Published in Nature communications (21.09.2020)
Published in Nature communications (21.09.2020)
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Journal Article
Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression
Hsu, Wen-Hao, LaBella, Kyle A, Lin, Yiyun, Xu, Ping, Lee, Rumi, Hsieh, Cheng-En, Yang, Lei, Zhou, Ashley, Blecher, Jonathan M, Wu, Chang-Jiun, Lin, Kangyu, Shang, Xiaoying, Jiang, Shan, Spring, Denise J, Xia, Yan, Chen, Peiwen, Shen, John Paul, Kopetz, Scott, DePinho, Ronald A
Published in Cancer discovery (12.12.2023)
Published in Cancer discovery (12.12.2023)
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Journal Article
Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer
Lee, Rumi, Li, Jiexi, Li, Jun, Wu, Chang-Jiun, Jiang, Shan, Hsu, Wen-Hao, Chakravarti, Deepavali, Chen, Peiwen, LaBella, Kyle A, Li, Jing, Spring, Denise J, Zhao, Di, Wang, Y Alan, DePinho, Ronald A
Published in Cancer discovery (06.07.2022)
Published in Cancer discovery (06.07.2022)
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Journal Article
Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model
Liu, Yonghong, Han, Jincheng, Hsu, Wen-Hao, LaBella, Kyle A, Deng, Pingna, Shang, Xiaoying, Tallon de Lara, Paulino, Cai, Li, Jiang, Shan, DePinho, Ronald A
Published in Cancer discovery (30.09.2024)
Published in Cancer discovery (30.09.2024)
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Journal Article
AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase
Yoshihama, Yohei, LaBella, Kyle A., Kim, Eiru, Bertolet, Lori, Colic, Medina, Li, Jiexi, Shang, Xiaoying, Wu, Chang-Jiun, Spring, Denise J., Wang, Y. Alan, Hart, Traver, DePinho, Ronald A.
Published in Proceedings of the National Academy of Sciences - PNAS (07.09.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (07.09.2021)
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Journal Article
Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
LaBella, Kyle A., Hsu, Wen-Hao, Li, Jiexi, Qi, Yutao, Liu, Yonghong, Liu, Jingjing, Wu, Chia-Chin, Liu, Yang, Song, Zingzhi, Lin, Yiyun, Blecher, Jonathan M., Jiang, Shan, Shang, Xiaoying, Han, Jincheng, Spring, Denise J., Zhang, Jianhua, Xia, Yan, DePinho, Ronald A.
Published in Developmental cell (03.06.2024)
Published in Developmental cell (03.06.2024)
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Journal Article
Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes
Chaturantabut, Saireudee, Shwartz, Arkadi, Evason, Kimberley J., Cox, Andrew G., Labella, Kyle, Schepers, Arnout G., Yang, Song, Acuña, Mariana, Houvras, Yariv, Mancio-Silva, Liliana, Romano, Shannon, Gorelick, Daniel A., Cohen, David E., Zon, Leonard I., Bhatia, Sangeeta N., North, Trista E., Goessling, Wolfram
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2019)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2019)
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Journal Article
Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood
Weeks, Olivia, Bossé, Gabriel D, Oderberg, Isaac M, Akle, Sebastian, Houvras, Yariv, Wrighton, Paul J, LaBella, Kyle, Iversen, Isabelle, Tavakoli, Sahar, Adatto, Isaac, Schwartz, Arkadi, Kloosterman, Daan, Tsomides, Allison, Charness, Michael E, Peterson, Randall T, Steinhauser, Matthew L, Fazeli, Pouneh K, Goessling, Wolfram
Published in The Journal of clinical investigation (01.05.2020)
Published in The Journal of clinical investigation (01.05.2020)
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Journal Article
Abstract 1073: PRMT5 inhibition synergizes with a natural small molecule compound to kill MTAP- deleted cells and suppress tumor growth
Barekatain, Yasaman, LaBella, Kyle, Sugimoto, Hikaru, Harris, Kristen, Khadka, Sunada, Muller, Florian, Kalluri, Raghu
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development
Chaturantabut, Saireudee, Shwartz, Arkadi, Garnaas, Maija K., LaBella, Kyle, Li, Chia‐Cheng, Carroll, Kelli J., Cutting, Claire C., Budrow, Nadine, Palaria, Amrita, Gorelick, Daniel A., Tremblay, Kimberly D., North, Trista E., Goessling, Wolfram
Published in Hepatology (Baltimore, Md.) (01.11.2020)
Published in Hepatology (Baltimore, Md.) (01.11.2020)
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Journal Article
Estrogen acts via estrogen receptor 2b to regulate hepatobiliary fate during vertebrate development
Chaturantabut, Saireudee, Shwartz, Arkadi, Garnaas, Maija K., LaBella, Kyle, Li, Chia-Cheng, Carroll, Kelli J., Cutting, Claire C., Budrow, Nadine, Palaria, Amrita, Gorelick, Daniel A., Tremblay, Kimberly D., North, Trista E., Goessling, Wolfram
Published in Hepatology (Baltimore, Md.) (01.11.2020)
Published in Hepatology (Baltimore, Md.) (01.11.2020)
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Journal Article
Oncogenic KRAS drives lipo–fibrogenesis to promote angiogenesis and colon cancer progression
Hsu, Wen-Hao, LaBella, Kyle A., Lin, Yiyun, Xu, Ping, Lee, Rumi, Hsieh, Cheng-En, Yang, Lei, Zhou, Ashley, Blecher, Jonathan M., Wu, Chang-Jiun, Lin, Kangyu, Shang, Xiaoying, Jiang, Shan, Spring, Denise J., Xia, Yan, Chen, Peiwen, Shen, John Paul, Kopetz, Scott, DePinho, Ronald A.
Published in Cancer discovery (12.12.2023)
Published in Cancer discovery (12.12.2023)
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Journal Article
Abstract IA20: Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
Han, Jincheng, Xu, Jiaqian, Liu, Yonghong, Liang, Shaoheng, LaBella, Kyle A., Chakravarti, Deepavali, Spring, Denise J., Xia, Yan, DePinho, Ronald A.
Published in Cancer research (Chicago, Ill.) (16.01.2024)
Published in Cancer research (Chicago, Ill.) (16.01.2024)
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Journal Article
Abstract 3515: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer
Li, Jiexi, Lan, Zhengdao, Liao, Wenting, Liu, Jielin, Jiang, Shan, Shim, Hong Seok, Slotnik, Max, LaBella, Kyle A., Hsu, Wen-Hao, Shang, Xiaoying, Spring, Denise, Wang, Y Alan, DePinho, Ronald A.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract IA014: Synthetic essentiality identifies TDO2 as a key target in APC-deficient CRC
Lee, Rumi, Li, Jiexi, Li, Jun, Wu, Chang-Jiun, Jiang, Shan, Hsu, Wen-Hao, Chakravarti, Deepavali, Chen, Peiwen, LaBella, Kyle A., Li, Jing, Spring, Denise J., Zhao, Di, Wang, Y. Alan, DePinho, Ronald A.
Published in Cancer research (Chicago, Ill.) (01.12.2022)
Published in Cancer research (Chicago, Ill.) (01.12.2022)
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