The safety of recombinant human hyaluronidase PH20 in nonclinical models: An overview of toxicology, pharmacology, and impact of anti-PH20 antibodies
Nolan, Ryan P., Kang, David W., Maneval, Daniel C., Knowles, Stephen P., LaBarre, Michael J., Printz, Marie A.
Published in Journal of controlled release (01.10.2024)
Published in Journal of controlled release (01.10.2024)
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Journal Article
Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression
Li, Xiaoming, Shepard, H Michael, Cowell, Jessica A, Zhao, Chunmei, Osgood, Ryan J, Rosengren, Sanna, Blouw, Barbara, Garrovillo, Sheryl A, Pagel, Mark D, Whatcott, Clifford J, Han, Haiyong, Von Hoff, Daniel D, Taverna, Darin M, LaBarre, Michael J, Maneval, Daniel C, Thompson, Curtis B
Published in Clinical cancer research (01.10.2018)
Published in Clinical cancer research (01.10.2018)
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Journal Article
Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors
Wang, Lin, Londono, Luz M, Cowell, Jessica, Saatci, Ozge, Aras, Mertkaya, Ersan, Pelin G, Serra, Sara, Pei, Hong, Clift, Renee, Zhao, Qiping, Phan, Kim B, Huang, Lei, LaBarre, Michael J, Li, Xiaoming, Shepard, H Michael, Deaglio, Silvia, Linden, Joel, Thanos, Christopher D, Sahin, Ozgur, Cekic, Caglar
Published in Cancer research (Chicago, Ill.) (15.06.2021)
Published in Cancer research (Chicago, Ill.) (15.06.2021)
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Journal Article
Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model
Connor, Robert J., Taverna, Darin M., Thrall, Karla, LaBarre, Michael J., Kang, David W.
Published in Journal of pharmacological and toxicological methods (01.11.2020)
Published in Journal of pharmacological and toxicological methods (01.11.2020)
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Journal Article
Risk Factors, Hyaluronidase Expression, and Clinical Immunogenicity of Recombinant Human Hyaluronidase PH20, an Enzyme Enabling Subcutaneous Drug Administration
Printz, Marie A., Sugarman, Barry J., Paladini, Rudolph D., Jorge, Michael C., Wang, Yan, Kang, David W., Maneval, Daniel C., LaBarre, Michael J.
Published in The AAPS journal (20.10.2022)
Published in The AAPS journal (20.10.2022)
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Journal Article
Kinetic investigation of recombinant human hyaluronidase PH20 on hyaluronic acid
Fang, Shiping, Hays Putnam, Anna-Maria A., LaBarre, Michael J.
Published in Analytical biochemistry (01.07.2015)
Published in Analytical biochemistry (01.07.2015)
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Journal Article
Abstract 2463: PEGPH20 increases the anticancer activity of standard chemotherapy combinations, vincristine (VIN) and D actinomycin (DACT), in a Wilms’ xenograft model
Cowell, Jessica, Zimmerman, Susan J., Marrela, Mathieu, Jiang, Ping, Houghton, Peter J., LaBarre, Michael J., Maneval, Daniel C., Thompson, Curtis B., Li, Xiaoming
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Novel APC-like properties of human NK cells directly regulate T cell activation
Hanna, Jacob, Gonen-Gross, Tsufit, Fitchett, Jonathan, Rowe, Tony, Daniels, Mark, Arnon, Tal I, Gazit, Roi, Joseph, Aviva, Schjetne, Karoline W, Steinle, Alexander, Porgador, Angel, Mevorach, Dror, Goldman-Wohl, Debra, Yagel, Simcha, LaBarre, Michael J, Buckner, Jane H, Mandelboim, Ofer
Published in The Journal of clinical investigation (01.12.2004)
Published in The Journal of clinical investigation (01.12.2004)
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Abstract 283: PEGylated recombinant hyaluronidase PH20 (PEGPH20) enhances pemetrexed antitumor efficacy in a human nonsquamous NSCLC xenograft model
Clift, Renee, Cowell, Jessica A., Zimmerman, Susan J., Marella, Mathieu, Jiang, Ping, Gelb, Arnold B., LaBarre, Michael J., Maneval, Daniel C., Thompson, Curtis B., Li, Xiaoming
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FCγRIII
Davies, Julian, Jiang, LiYing, Pan, Li-Zhen, LaBarre, Michael J., Anderson, Darrell, Reff, Mitchell
Published in Biotechnology and bioengineering (20.08.2001)
Published in Biotechnology and bioengineering (20.08.2001)
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Journal Article
Development and validation of a liquid chromatography method for simultaneous determination of three process-related impurities: yeastolates, triton X-100 and methotrexate
Fang, Shiping, Lollo, Charles P., Derunes, Celine, LaBarre, Michael J.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.11.2011)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.11.2011)
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An Intermediate pH Unfolding Transition Abrogates the Ability of IgE to Interact with Its High Affinity Receptor FcϵRIα
Demarest, Stephen J., Hopp, Jennifer, Chung, Julie, Hathaway, Karen, Mertsching, Elisabeth, Cao, Xianjun, George, Judy, Miatkowski, Konrad, LaBarre, Michael J., Shields, Michael, Kehry, Marilyn R.
Published in The Journal of biological chemistry (13.10.2006)
Published in The Journal of biological chemistry (13.10.2006)
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Journal Article
Proteomic analysis of human natural killer cells: insights on new potential NK immune functions
Hanna, Jacob, Fitchett, Jonathan, Rowe, Tony, Daniels, Mark, Heller, Melissa, Gonen-Gross, Tsufit, Manaster, Efrat, Cho, Samuel Y., LaBarre, Michael J., Mandelboim, Ofer
Published in Molecular immunology (01.02.2005)
Published in Molecular immunology (01.02.2005)
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Journal Article
Plasma hyaluronan is a predictive marker for pegvorhyaluronidase alfa (PEGPH20; PVHA) response in a phase II study of pancreatic ductal adenocarcinoma (PDAC)
Taverna, Darin, Printz, Marie, LaBarre, Michael J., Sekulovich, Rose E.
Published in Journal of clinical oncology (01.02.2019)
Published in Journal of clinical oncology (01.02.2019)
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Journal Article
Abstract 1755: PEGylated adenosine deaminase (ADA2) prevents adenosine-mediated increase in tumor growth and improves antitumor immune responses
Londoño-R, Luz Marina, Cowell, Jessica, Wang, Lin, Zhao, Qiping, Huang, Lei, Thanos, Chris, LaBarre, Michael J., Li, Xiaoming, Cekic, Caglar
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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