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A commensal strain of Staphylococcus epidermidis protects against skin neoplasia
Nakatsuji, Teruaki, Chen, Tiffany H., Butcher, Anna M., Trzoss, Lynnie L., Nam, Sang-Jip, Shirakawa, Karina T., Zhou, Wei, Oh, Julia, Otto, Michael, Fenical, William, Gallo, Richard L.
Published in Science advances (01.02.2018)
Published in Science advances (01.02.2018)
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Journal Article
Nature-Inspired Total Synthesis of (−)-Fusarisetin A
Xu, Jing, Caro-Diaz, Eduardo J. E, Trzoss, Lynnie, Theodorakis, Emmanuel A
Published in Journal of the American Chemical Society (21.03.2012)
Published in Journal of the American Chemical Society (21.03.2012)
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Journal Article
JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders
Ambrus-Aikelin, Geza, Takeda, Katsuyuki, Joetham, Anthony, Lazic, Milos, Povero, Davide, Santini, Angelina M., Pranadinata, Rama, Johnson, Casey D., McGeough, Matthew D., Beasley, Federico C., Stansfield, Ryan, McBride, Christopher, Trzoss, Lynnie, Hoffman, Hal M., Feldstein, Ariel E., Stafford, Jeffrey A., Veal, James M., Bain, Gretchen, Gelfand, Erwin W.
Published in Scientific reports (19.08.2023)
Published in Scientific reports (19.08.2023)
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Journal Article
Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin
Trzoss, Lynnie, Fukuda, Takashi, Costa-Lotufo, Letícia V., Jimenez, Paula, La Clair, James J., Fenical, William
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2014)
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Journal Article
Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders
Ambrus-Aikelin, Geza, Takeda, Katsuyuki, Joetham, Anthony, Lazic, Milos, Povero, Davide, Santini, Angelina M., Pranadinata, Rama, Johnson, Casey D., McGeough, Matthew D., Beasley, Federico C., Stansfield, Ryan, McBride, Christopher, Trzoss, Lynnie, Hoffman, Hal M., Feldstein, Ariel E., Stafford, Jeffrey A., Veal, James M., Bain, Gretchen, Gelfand, Erwin W.
Published in Scientific reports (16.11.2023)
Published in Scientific reports (16.11.2023)
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Journal Article
Enantioselective Synthesis of (−)-Jiadifenin, a Potent Neurotrophic Modulator
Trzoss, Lynnie, Xu, Jing, Lacoske, Michelle H, Mobley, William C, Theodorakis, Emmanuel A
Published in Organic letters (02.09.2011)
Published in Organic letters (02.09.2011)
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Journal Article
Intramolecular cyclization strategies toward the synthesis of zoanthamine alkaloids
Fischer, Derek, Nguyen, Thong X., Trzoss, Lynnie, Dakanali, Marianna, Theodorakis, Emmanuel A.
Published in Tetrahedron letters (21.09.2011)
Published in Tetrahedron letters (21.09.2011)
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Journal Article
Integration of Genomic Data with NMR Analysis Enables Assignment of the Full Stereostructure of Neaumycin B, a Potent Inhibitor of Glioblastoma from a Marine-Derived Micromonospora
Kim, Min Cheol, Machado, Henrique, Jang, Kyoung Hwa, Trzoss, Lynnie, Jensen, Paul R, Fenical, William
Published in Journal of the American Chemical Society (29.08.2018)
Published in Journal of the American Chemical Society (29.08.2018)
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Journal Article
Overcoming Preclinical Safety Obstacles to Discover (S)‑N‑((1,2,3,5,6,7-Hexahydro‑s‑indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro‑5H‑pyrazolo[5,1‑b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A., Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T., Townsend, Michael J., Stivala, Craig E.
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A., Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T., Townsend, Michael J., Stivala, Craig E.
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
AZETIDINE AND PYRROLIDINE PARP1 INHIBITORS AND USES THEREOF
LYNNIE TRZOSS, DONG QING, PORINO JINJO VA, STEPHEN W KALDOR, ROBERT L HOFFMAN
Year of Publication 19.02.2025
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Year of Publication 19.02.2025
Patent
Enantioselective Total Synthesis of (−)-Jiadifenolide
Xu, Jing, Trzoss, Lynnie, Chang, Weng K., Theodorakis, Emmanuel A.
Published in Angewandte Chemie International Edition (11.04.2011)
Published in Angewandte Chemie International Edition (11.04.2011)
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Journal Article
PARP1 INHIBITORS AND USES THEREOF
LYNNIE TRZOSS, PORINO JINJO VA, JOSEPH ROBERT PINCHMAN, DONG QING, STEPHEN W KALDOR, ROBERT L HOFFMAN
Year of Publication 07.03.2025
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Year of Publication 07.03.2025
Patent
Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo5,1-b1,3oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A, Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T, Townsend, Michael J, Stivala, Craig E
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
THERAPEUTIC COMPOUNDS
LYNNIE TRZOSS, AMOGH BOLOOR, JUAN MANUEL BETANCORT, WALLACE MICHAEL BRENNAN, TOUFIKE KANOUNI
Year of Publication 27.06.2023
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Year of Publication 27.06.2023
Patent