Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate
Letavic, Michael A., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Koudriakova, Tatiana, Lord, Brian, Lovenberg, Timothy W., Ly, Kiev S., Mani, Neelakandha S., Nepomuceno, Diane, Pippel, Daniel J., Rizzolio, Michele, Shelton, Jonathan E., Shah, Chandra R., Shireman, Brock T., Young, Lana K., Yun, Sujin
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Dual serotonin transporter/histamine H3 ligands : Optimization of the H3 pharmacophore
KEITH, John M, GOMEZ, Leslie A, MAZUR, Curt, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, LETAVIC, Michael A, LY, Kiev S, JABLONOWSKI, Jill A, SEIERSTAD, Mark, BARBIER, Ann J, WILSON, Sandy J, BOGGS, Jamin D, FRASER, Ian C
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development
Letavic, Michael A, Aluisio, Leah, Apodaca, Richard, Bajpai, Manoj, Barbier, Ann J, Bonneville, Anne, Bonaventure, Pascal, Carruthers, Nicholas I, Dugovic, Christine, Fraser, Ian C, Kramer, Michelle L, Lord, Brian, Lovenberg, Timothy W, Li, Lilian Y, Ly, Kiev S, Mcallister, Heather, Mani, Neelakandha S, Morton, Kirsten L, Ndifor, Anthony, Nepomuceno, S. Diane, Pandit, Chennagiri R, Sands, Steven B, Shah, Chandra R, Shelton, Jonathan E, Snook, Sandra S, Swanson, Devin M, Xiao, Wei
Published in ACS medicinal chemistry letters (09.04.2015)
Published in ACS medicinal chemistry letters (09.04.2015)
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Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors
LY, Kiev S, LETAVIC, Michael A, DVORAK, Lisa, MILLER, Kirsten L, NEPOMUCENO, Diane, WILSON, Sandy J, CARRUTHERS, Nicholas I, KEITH, John M, MILLER, Jennifer M, STOCKING, Emily M, BARBIER, Ann J, BONAVENTURE, Pascal, LORD, Brian, XIAOHUI JIANG, BOGGS, Jamin D
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists
STOCKING, Emily M, ALUISIO, Leah, LORD, Brian, LY, Kiev S, MORTON, Kirsten L, NEPOMUCENO, Diane, SHAH, Chandravadan R, SHELTON, Jonathan, SOYODE-JOHNSON, Akinola, LETAVIC, Michael A, ATACK, John R, BONAVENTURE, Pascal, CARRUTHERS, Nicholas I, DUGOVIC, Christine, EVERSON, Anita, FRASER, Ian, XIAOHUI JIANG, LEUNG, Perry
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists
Jablonowski, Jill A, Grice, Cheryl A, Chai, Wenying, Dvorak, Curt A, Venable, Jennifer D, Kwok, Annette K, Ly, Kiev S, Wei, Jianmei, Baker, Sherry M, Desai, Pragnya J, Jiang, Wen, Wilson, Sandy J, Thurmond, Robin L, Karlsson, Lars, Edwards, James P, Lovenberg, Timothy W, Carruthers, Nicholas I
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors
LETAVIC, Michael A, KEITH, John M, LY, Kiev S, BARBIER, Ann J, BOGGS, Jamin D, WILSON, Sandy J, LORD, Brian, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
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2-Aryloxymethylmorpholine histamine H(3) antagonists
Letavic, Michael A, Keith, John M, Ly, Kiev S, Bonaventure, Pascal, Feinstein, Mark A, Lord, Brian, Miller, Kirsten L, Motley, S Timothy, Nepomuceno, Diane, Sutton, Steven W, Carruthers, Nicholas I
Published in Bioorganic & medicinal chemistry letters (01.11.2008)
Published in Bioorganic & medicinal chemistry letters (01.11.2008)
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Journal Article
Preparation and Biological Evaluation of Indole, Benzimidazole, and Thienopyrrole Piperazine Carboxamides: Potent Human Histamine H4 Antagonists
Venable, Jennifer D, Cai, Hui, Chai, Wenying, Dvorak, Curt A, Grice, Cheryl A, Jablonowski, Jill A, Shah, Chandra R, Kwok, Annette K, Ly, Kiev S, Pio, Barbara, Wei, Jianmei, Desai, Pragnya J, Jiang, Wen, Nguyen, Steven, Ling, Ping, Wilson, Sandy J, Dunford, Paul J, Thurmond, Robin L, Lovenberg, Timothy W, Karlsson, Lars, Carruthers, Nicholas I, Edwards, James P
Published in Journal of medicinal chemistry (29.12.2005)
Published in Journal of medicinal chemistry (29.12.2005)
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Journal Article
Novel imidazole-based histamine H3 antagonists
JABLONOWSKI, Jill A, LY, Kiev S, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, BOGENSTAETTER, Michael, DVORAK, Curt A, BOGGS, Jamin D, DVORAK, Lisa K, LORD, Brian, MILLER, Kirsten L, MAZUR, Curt, WILSON, Sandy J
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical development
Letavic, Michael A., Aluisio, Leah, Atack, John R., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Everson, Anita, Feinstein, Mark A., Fraser, Ian C., Hoey, Kenway, Jiang, Xiaohui, Keith, John M., Koudriakova, Tatiana, Leung, Perry, Lord, Brian, Lovenberg, Timothy W., Ly, Kiev S., Morton, Kirsten L., Timothy Motley, S., Nepomuceno, Diane, Rizzolio, Michele, Rynberg, Raymond, Sepassi, Kia, Shelton, Jonathan
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
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Journal Article
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors
LETAVIC, Michael A, KEITH, John M, WILSON, Sandy J, MILLER, Kirsten L, LORD, Brian, MCALLISTER, Heather M, TOGNARELLI, D. J, JIEJUN WU, ABAD, Marta C, SCHUBERT, Carsten, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, JABLONOWSKI, Jill A, STOCKING, Emily M, GOMEZ, Leslie A, LY, Kiev S, MILLER, Jennifer M, BARBIER, Ann J, BONAVENTURE, Pascal, BOGGS, Jamin D
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
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Journal Article
2-Aryloxymethylmorpholine histamine H3 antagonists
LETAVIC, Michael A, KEITH, John M, CARRUTHERS, Nicholas I, LY, Kiev S, BONAVENTURE, Pascal, FEINSTEIN, Mark A, LORD, Brian, MILLER, Kirsten L, MOTLEY, S. Timothy, NEPOMUCENO, Diane, SUTTON, Steven W
Published in Bioorganic & medicinal chemistry letters (01.11.2008)
Published in Bioorganic & medicinal chemistry letters (01.11.2008)
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Journal Article
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: Potent human histamine H-4 antagonists
Venable, JD, Cai, H, Chai, WY, Dvorak, CA, Grice, CA, Jablonowski, JA, Shah, CR, Kwok, AK, Ly, KS, Pio, B, Wei, JM, Desai, PJ, Jiang, W, Nguyen, S, Ling, P, Wilson, SJ, Dunford, PJ, Thurmond, RL, Lovenberg, TW, Karlsson, L, Carruthers, NI, Edwards, JP
Published in Journal of medicinal chemistry (29.12.2005)
Published in Journal of medicinal chemistry (29.12.2005)
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Journal Article
Synthesis of a Histamine H-3 Receptor Antagonist-Manipulation of Hydroxyproline Stereochemistry, Desymmetrization of Homopiperazine, and Nonextractive Sodium Triacetoxyborohydride Reaction Workup
Pippel, Daniel J., Young, Lana K., Letavic, Michael A., Ly, Kiev S., Naderi, Bita, Soyode-Johnson, Aki, Stocking, Emily M., Carruthers, Nicholas I., Mani, Neelakandha S.
Published in Journal of organic chemistry (02.07.2010)
Published in Journal of organic chemistry (02.07.2010)
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Journal Article
Dual serotonin transporter/histamine H 3 ligands: Optimization of the H 3 pharmacophore
Keith, John M., Gomez, Leslie A., Letavic, Michael A., Ly, Kiev S., Jablonowski, Jill A., Seierstad, Mark, Barbier, Ann J., Wilson, Sandy J., Boggs, Jamin D., Fraser, Ian C., Mazur, Curt, Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Journal Article
Synthesis and biological activity of piperazine and diazepane amides that are histamine H 3 antagonists and serotonin reuptake inhibitors
Ly, Kiev S., Letavic, Michael A., Keith, John M., Miller, Jennifer M., Stocking, Emily M., Barbier, Ann J., Bonaventure, Pascal, Lord, Brian, Jiang, Xiaohui, Boggs, Jamin D., Dvorak, Lisa, Miller, Kirsten L., Nepomuceno, Diane, Wilson, Sandy J., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Journal Article
Synthesis of a Histamine H3 Receptor AntagonistManipulation of Hydroxyproline Stereochemistry, Desymmetrization of Homopiperazine, and Nonextractive Sodium Triacetoxyborohydride Reaction Workup
Pippel, Daniel J, Young, Lana K, Letavic, Michael A, Ly, Kiev S, Naderi, Bita, Soyode-Johnson, Aki, Stocking, Emily M, Carruthers, Nicholas I, Mani, Neelakandha S
Published in Journal of organic chemistry (02.07.2010)
Published in Journal of organic chemistry (02.07.2010)
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Journal Article