Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
Wang, Zeneng, Roberts, Adam B., Buffa, Jennifer A., Levison, Bruce S., Zhu, Weifei, Org, Elin, Gu, Xiaodong, Huang, Ying, Zamanian-Daryoush, Maryam, Culley, Miranda K., DiDonato, Anthony J., Fu, Xiaoming, Hazen, Jennie E., Krajcik, Daniel, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
Published in Cell (17.12.2015)
Published in Cell (17.12.2015)
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Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis
von Scheidt, Moritz, Zhao, Yuqi, Kurt, Zeyneb, Pan, Calvin, Zeng, Lingyao, Yang, Xia, Schunkert, Heribert, Lusis, Aldons J.
Published in Cell metabolism (07.02.2017)
Published in Cell metabolism (07.02.2017)
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The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases
Laakso, Markku, Kuusisto, Johanna, Stančáková, Alena, Kuulasmaa, Teemu, Pajukanta, Päivi, Lusis, Aldons J., Collins, Francis S., Mohlke, Karen L., Boehnke, Michael
Published in Journal of lipid research (01.03.2017)
Published in Journal of lipid research (01.03.2017)
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Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
Org, Elin, Blum, Yuna, Kasela, Silva, Mehrabian, Margarete, Kuusisto, Johanna, Kangas, Antti J, Soininen, Pasi, Wang, Zeneng, Ala-Korpela, Mika, Hazen, Stanley L, Laakso, Markku, Lusis, Aldons J
Published in Genome Biology (13.04.2017)
Published in Genome Biology (13.04.2017)
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Sex differences in metabolism and cardiometabolic disorders
Chella Krishnan, Karthickeyan, Mehrabian, Margarete, Lusis, Aldons J
Published in Current opinion in lipidology (01.10.2018)
Published in Current opinion in lipidology (01.10.2018)
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Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice
Zhang, Wenchao, Miikeda, Aika, Zuckerman, Jonathan, Jia, Xun, Charugundla, Sarada, Zhou, Zhiqiang, Kaczor-Urbanowicz, Karolina Elżbieta, Magyar, Clara, Guo, Fangfei, Wang, Zeneng, Pellegrini, Matteo, Hazen, Stanley L., Nicholas, Susanne B., Lusis, Aldons J., Shih, Diana M.
Published in Scientific reports (12.01.2021)
Published in Scientific reports (12.01.2021)
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Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
Zhou, Meiyi, Shao, Jing, Wu, Cheng-Yang, Shu, Le, Dong, Weibing, Liu, Yunxia, Chen, Mengping, Wynn, R Max, Wang, Jiqiu, Wang, Ji, Gui, Wen-Jun, Qi, Xiangbing, Lusis, Aldons J, Li, Zhaoping, Wang, Weiqing, Ning, Guang, Yang, Xia, Chuang, David T, Wang, Yibin, Sun, Haipeng
Published in Diabetes (New York, N.Y.) (01.09.2019)
Published in Diabetes (New York, N.Y.) (01.09.2019)
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Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, Weifei, Gregory, Jill C., Org, Elin, Buffa, Jennifer A., Gupta, Nilaksh, Wang, Zeneng, Li, Lin, Fu, Xiaoming, Wu, Yuping, Mehrabian, Margarete, Sartor, R. Balfour, McIntyre, Thomas M., Silverstein, Roy L., Tang, W.H. Wilson, DiDonato, Joseph A., Brown, J. Mark, Lusis, Aldons J., Hazen, Stanley L.
Published in Cell (24.03.2016)
Published in Cell (24.03.2016)
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Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB
Seldin, Marcus M., Meng, Yonghong, Qi, Hongxiu, Zhu, WeiFei, Wang, Zeneng, Hazen, Stanley L., Lusis, Aldons J., Shih, Diana M.
Published in Journal of the American Heart Association (01.02.2016)
Published in Journal of the American Heart Association (01.02.2016)
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Sex differences and hormonal effects on gut microbiota composition in mice
Org, Elin, Mehrabian, Margarete, Parks, Brian W., Shipkova, Petia, Liu, Xiaoqin, Drake, Thomas A., Lusis, Aldons J.
Published in Gut microbes (03.07.2016)
Published in Gut microbes (03.07.2016)
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Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice
Parks, Brian W., Nam, Elizabeth, Org, Elin, Kostem, Emrah, Norheim, Frode, Hui, Simon T., Pan, Calvin, Civelek, Mete, Rau, Christoph D., Bennett, Brian J., Mehrabian, Margarete, Ursell, Luke K., He, Aiqing, Castellani, Lawrence W., Zinker, Bradley, Kirby, Mark, Drake, Thomas A., Drevon, Christian A., Knight, Rob, Gargalovic, Peter, Kirchgessner, Todd, Eskin, Eleazar, Lusis, Aldons J.
Published in Cell metabolism (08.01.2013)
Published in Cell metabolism (08.01.2013)
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Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association
Daugherty, Alan, Tall, Alan R, Daemen, Mat J.A.P, Falk, Erling, Fisher, Edward A, García-Cardeña, Guillermo, Lusis, Aldons J, Owens, A Phillip, Rosenfeld, Michael E, Virmani, Renu
Published in Arteriosclerosis, thrombosis, and vascular biology (01.09.2017)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.09.2017)
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Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration
Patterson, Michaela, Barske, Lindsey, Van Handel, Ben, Rau, Christoph D, Gan, Peiheng, Sharma, Avneesh, Parikh, Shan, Denholtz, Matt, Huang, Ying, Yamaguchi, Yukiko, Shen, Hua, Allayee, Hooman, Crump, J Gage, Force, Thomas I, Lien, Ching-Ling, Makita, Takako, Lusis, Aldons J, Kumar, S Ram, Sucov, Henry M
Published in Nature genetics (01.09.2017)
Published in Nature genetics (01.09.2017)
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Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential
Roberts, Adam B., Gu, Xiaodong, Buffa, Jennifer A., Hurd, Alex G., Wang, Zeneng, Zhu, Weifei, Gupta, Nilaksh, Skye, Sarah M., Cody, David B., Levison, Bruce S., Barrington, William T., Russell, Matthew W., Reed, Jodie M., Duzan, Ashraf, Lang, Jennifer M., Fu, Xiaoming, Li, Lin, Myers, Alex J., Rachakonda, Suguna, DiDonato, Joseph A., Brown, J. Mark, Gogonea, Valentin, Lusis, Aldons J., Garcia-Garcia, Jose Carlos, Hazen, Stanley L.
Published in Nature medicine (01.09.2018)
Published in Nature medicine (01.09.2018)
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γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L-Carnitine to TMAO
Koeth, Robert A., Levison, Bruce S., Culley, Miranda K., Buffa, Jennifer A., Wang, Zeneng, Gregory, Jill C., Org, Elin, Wu, Yuping, Li, Lin, Smith, Jonathan D., Tang, W.H. Wilson, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
Published in Cell metabolism (04.11.2014)
Published in Cell metabolism (04.11.2014)
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Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
Sallam, Tamer, Jones, Marius, Thomas, Brandon J, Wu, Xiaohui, Gilliland, Thomas, Qian, Kevin, Eskin, Ascia, Casero, David, Zhang, Zhengyi, Sandhu, Jaspreet, Salisbury, David, Rajbhandari, Prashant, Civelek, Mete, Hong, Cynthia, Ito, Ayaka, Liu, Xin, Daniel, Bence, Lusis, Aldons J, Whitelegge, Julian, Nagy, Laszlo, Castrillo, Antonio, Smale, Stephen, Tontonoz, Peter
Published in Nature medicine (01.03.2018)
Published in Nature medicine (01.03.2018)
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Specific approaches and limitations in (multi)-omic Mendelian randomization
Cupido, Arjen J., Zhou, Mingqi, Lusis, Aldons J., Seldin, Marcus
Published in Journal of lipid research (01.10.2024)
Published in Journal of lipid research (01.10.2024)
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Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation
Bennett, Brian J., Vallim, Thomas Q. de Aguiar, Wang, Zeneng, Shih, Diana M., Meng, Yonghong, Gregory, Jill, Allayee, Hooman, Lee, Richard, Graham, Mark, Crooke, Rosanne, Edwards, Peter A., Hazen, Stanley L., Lusis, Aldons J.
Published in Cell metabolism (08.01.2013)
Published in Cell metabolism (08.01.2013)
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