Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Guo, Yunhang, Liu, Ye, Hu, Nan, Yu, Desheng, Zhou, Changyou, Shi, Gongyin, Zhang, Bo, Wei, Min, Liu, Junhua, Luo, Lusong, Tang, Zhiyu, Song, Huipeng, Guo, Yin, Liu, Xuesong, Su, Dan, Zhang, Shuo, Song, Xiaomin, Zhou, Xing, Hong, Yuan, Chen, Shuaishuai, Cheng, Zhenzhen, Young, Steve, Wei, Qiang, Wang, Haisheng, Wang, Qiuwen, Lv, Lei, Wang, Fan, Xu, Haipeng, Sun, Hanzi, Xing, Haimei, Li, Na, Zhang, Wei, Wang, Zhongbo, Liu, Guodong, Sun, Zhijian, Zhou, Dongping, Li, Wei, Liu, Libin, Wang, Lai, Wang, Zhiwei
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia
Ariazi, Jennifer L, Duffy, Kevin J, Adams, David F, Fitch, Duke M, Luo, Lusong, Pappalardi, Melissa, Biju, Mangatt, DiFilippo, Erin Hugger, Shaw, Tony, Wiggall, Ken, Erickson-Miller, Connie
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
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Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor
Van Aller, Glenn S., Carson, Jeff D., Tang, Wei, Peng, Hao, Zhao, Lin, Copeland, Robert A., Tummino, Peter J., Luo, Lusong
Published in Biochemical and biophysical research communications (11.03.2011)
Published in Biochemical and biophysical research communications (11.03.2011)
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BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers
Tang, Zhiyu, Yuan, Xi, Du, Rong, Cheung, Shing-Hu, Zhang, Guoliang, Wei, Jing, Zhao, Yuan, Feng, Yingcai, Peng, Hao, Zhang, Yi, Du, Yunguang, Hu, Xiaoxia, Gong, Wenfeng, Liu, Yong, Gao, Yajuan, Liu, Ye, Hao, Rui, Li, Shengjian, Wang, Shaohui, Ji, Jiafu, Zhang, Lianhai, Li, Shuangxi, Sutton, David, Wei, Min, Zhou, Changyou, Wang, Lai, Luo, Lusong
Published in Molecular cancer therapeutics (01.10.2015)
Published in Molecular cancer therapeutics (01.10.2015)
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RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K‐RAS mutant tumors
Yuan, Xi, Tang, Zhiyu, Du, Rong, Yao, Zhan, Cheung, Shing‐Hu, Zhang, Xinwen, Wei, Jing, Zhao, Yuan, Du, Yunguang, Liu, Ye, Hu, Xiaoxia, Gong, Wenfeng, Liu, Yong, Gao, Yajuan, Huang, Zhiyue, Cao, Zongfu, Wei, Min, Zhou, Changyou, Wang, Lai, Rosen, Neal, Smith, Paul D., Luo, Lusong
Published in Molecular oncology (01.08.2020)
Published in Molecular oncology (01.08.2020)
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Discovery of a potent hedgehog pathway inhibitor capable of activating caspase8-dependent apoptosis
Chen, Qin, Zhang, Haoran, Wu, Meng, Wang, Qin, Luo, Lusong, Ma, Haikuo, Zhang, Xiaohu, He, Sudan
Published in Journal of pharmacological sciences (01.07.2018)
Published in Journal of pharmacological sciences (01.07.2018)
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Mechanism of Inhibition of Human KSP by Ispinesib
Lad, Latesh, Luo, Lusong, Carson, Jeffrey D., Wood, Kenneth W., Hartman, James J., Copeland, Robert A., Sakowicz, Roman
Published in Biochemistry (Easton) (18.03.2008)
Published in Biochemistry (Easton) (18.03.2008)
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Novel ATP-Competitive Kinesin Spindle Protein Inhibitors
Parrish, Cynthia A, Adams, Nicholas D, Auger, Kurt R, Burgess, Joelle L, Carson, Jeffrey D, Chaudhari, Amita M, Copeland, Robert A, Diamond, Melody A, Donatelli, Carla A, Duffy, Kevin J, Faucette, Leo F, Finer, Jeffrey T, Huffman, William F, Hugger, Erin D, Jackson, Jeffrey R, Knight, Steven D, Luo, Lusong, Moore, Michael L, Newlander, Ken A, Ridgers, Lance H, Sakowicz, Roman, Shaw, Antony N, Sung, Chiu-Mei M, Sutton, David, Wood, Kenneth W, Zhang, Shu-Yun, Zimmerman, Michael N, Dhanak, Dashyant
Published in Journal of medicinal chemistry (04.10.2007)
Published in Journal of medicinal chemistry (04.10.2007)
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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295
Qian, Xiangping, McDonald, Andrew, Zhou, Han-Jie, Adams, Nicholas D, Parrish, Cynthia A, Duffy, Kevin J, Fitch, Duke M, Tedesco, Rosanna, Ashcraft, Luke W, Yao, Bing, Jiang, Hong, Huang, Jennifer K, Marin, Melchor V, Aroyan, Carrie E, Wang, Jianchao, Ahmed, Seyed, Burgess, Joelle L, Chaudhari, Amita M, Donatelli, Carla A, Darcy, Michael G, Ridgers, Lance H, Newlander, Ken A, Schmidt, Stanley J, Chai, Deping, Colón, Mariela, Zimmerman, Michael N, Lad, Latesh, Sakowicz, Roman, Schauer, Stephen, Belmont, Lisa, Baliga, Ramesh, Pierce, Daniel W, Finer, Jeffrey T, Wang, Zhengping, Morgan, Bradley P, Morgans, David J, Auger, Kurt R, Sung, Chiu-Mei, Carson, Jeff D, Luo, Lusong, Hugger, Erin D, Copeland, Robert A, Sutton, David, Elliott, John D, Jackson, Jeffrey R, Wood, Kenneth W, Dhanak, Dashyant, Bergnes, Gustave, Knight, Steven D
Published in ACS medicinal chemistry letters (08.04.2010)
Published in ACS medicinal chemistry letters (08.04.2010)
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Timing of Epimerization and Condensation Reactions in Nonribosomal Peptide Assembly Lines: Kinetic Analysis of Phenylalanine Activating Elongation Modules of Tyrocidine Synthetase B
Luo, Lusong, Kohli, Rahul M, Onishi, Megumi, Linne, Uwe, Marahiel, Mohamed A, Walsh, Christopher T
Published in Biochemistry (Easton) (23.07.2002)
Published in Biochemistry (Easton) (23.07.2002)
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Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR)
Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn, Carson, Jeff D., Elkins, Patricia A., Diamond, Melody, Gardiner, Christine M., Garver, Eric, Luo, Lusong, Raha, Kaushik, Sung, Chiu-Mei, Tummino, Peter J., Auger, Kurt R., Dhanak, Dashyant
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition
Yao, Zhan, Torres, Neilawattie M., Tao, Anthony, Gao, Yijun, Luo, Lusong, Li, Qi, de Stanchina, Elisa, Abdel-Wahab, Omar, Solit, David B., Poulikakos, Poulikos I., Rosen, Neal
Published in Cancer cell (14.09.2015)
Published in Cancer cell (14.09.2015)
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Phase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors
Desai, Jayesh, Gan, Hui, Barrow, Catherine, Jameson, Michael, Atkinson, Victoria, Haydon, Andrew, Millward, Michael, Begbie, Stephen, Brown, Michael, Markman, Ben, Patterson, William, Hill, Andrew, Horvath, Lisa, Nagrial, Adnan, Richardson, Gary, Jackson, Christopher, Friedlander, Michael, Parente, Phillip, Tran, Ben, Wang, Lai, Chen, Yunxin, Tang, Zhiyu, Huang, Wendy, Wu, John, Zeng, Dewan, Luo, Lusong, Solomon, Benjamin
Published in Journal of clinical oncology (01.07.2020)
Published in Journal of clinical oncology (01.07.2020)
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Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays
Lu, Wenfeng, Zhang, Dihua, Ma, Haikuo, Tian, Sheng, Zheng, Jiyue, Wang, Qin, Luo, Lusong, Zhang, Xiaohu
Published in European journal of medicinal chemistry (15.07.2018)
Published in European journal of medicinal chemistry (15.07.2018)
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Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development
Wang, Hexiang, Ren, Bo, Liu, Ye, Jiang, Beibei, Guo, Yin, Wei, Min, Luo, Lusong, Kuang, Xianzhao, Qiu, Ming, Lv, Lei, Xu, Hong, Qi, Ruipeng, Yan, Huibin, Xu, Dexu, Wang, Zhiwei, Huo, Chang-Xin, Zhu, Yutong, Zhao, Yuan, Wu, Yiyuan, Qin, Zhen, Su, Dan, Tang, Tristin, Wang, Fan, Sun, Xuebing, Feng, Yingcai, Peng, Hao, Wang, Xing, Gao, Yajuan, Liu, Yong, Gong, Wenfeng, Yu, Fenglong, Liu, Xuesong, Wang, Lai, Zhou, Changyou
Published in Journal of medicinal chemistry (24.12.2020)
Published in Journal of medicinal chemistry (24.12.2020)
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Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity
Li, Zhanhui, Wang, Xu, Lin, Yu, Wang, Yujie, Wu, Shuwei, Xia, Kaijiang, Xu, Chen, Ma, Haikuo, Zheng, Jiyue, Luo, Lusong, Zhu, Fang, He, Sudan, Zhang, Xiaohu
Published in European journal of medicinal chemistry (01.11.2020)
Published in European journal of medicinal chemistry (01.11.2020)
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