L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase
YOUNG, S. D, BRITCHER, S. F, PETTIBONE, D. J, O'BRIEN, J. A, BALL, R. G, BALANI, S. K, LIN, J. H, I-WU CHEN, SCHLEIF, W. A, SARDANA, V. V, LONG, W. J, BYRNES, V. W, TRAN, L. O, EMINI, E. A, PAYNE, L. S, LUMMA, W. C, LYLE, T. A, HUFF, J. R, ANDERSON, P. S, OLSEN, D. B, CARROLL, S. S
Published in Antimicrobial Agents and Chemotherapy (01.12.1995)
Published in Antimicrobial Agents and Chemotherapy (01.12.1995)
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Journal Article
Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models
LOBELL, Robert B, OMER, Charles A, KRAL, Astrid M, DONGMING LIU, LUMMA, William C, MACHOTKA, Samuel V, RANDS, Elaine, WILLIAMS, Theresa M, GRAHAM, Samuel L, HARTMAN, George D, OLIFF, Allen I, HEIMBROOK, David C, ABRAMS, Marc T, KOHL, Nancy E, BHIMNATHWALA, Hema G, BRUCKER, Mary Jo, BUSER, Carolyn A, DAVIDE, Joseph P, DESOLMS, S. Jane, DINSMORE, Christopher J, ELLIS-HUTCHINGS, Michelle S
Published in Cancer research (Chicago, Ill.) (15.12.2001)
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Published in Cancer research (Chicago, Ill.) (15.12.2001)
Journal Article
Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation
Wong, Birming, Lumma, William C., Smith, Anthony M., Sisko, John T., Wright, Samuel D., Cai, Tian‐Quan
Published in Journal of leukocyte biology (01.06.2001)
Published in Journal of leukocyte biology (01.06.2001)
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Journal Article
Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures: Rapid Structure−Activity Studies by Solid-Phase Synthesis
Lumma, William C, Witherup, Keith M, Tucker, Thomas J, Brady, Steven F, Sisko, John T, Naylor-Olsen, Adel M, Lewis, S. Dale, Lucas, Bobby J, Vacca, Joseph P
Published in Journal of medicinal chemistry (26.03.1998)
Published in Journal of medicinal chemistry (26.03.1998)
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Journal Article
Design of Highly Potent Noncovalent Thrombin Inhibitors That Utilize a Novel Lipophilic Binding Pocket in the Thrombin Active Site
Tucker, Thomas J, Lumma, William C, Mulichak, Anne M, Chen, Zhongguo, Naylor-Olsen, Adel M, Lewis, S. Dale, Lucas, Robert, Freidinger, Roger M, Kuo, Lawrence C
Published in Journal of medicinal chemistry (14.03.1997)
Published in Journal of medicinal chemistry (14.03.1997)
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Journal Article
Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position
Tucker, Thomas J, Brady, Stephen F, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Naylor-Olsen, Adel M, Yan, Youwei, Sisko, Jack T, Stauffer, Kenneth J, Lucas, Bobby J, Lynch, Joseph J, Cook, Jacquelynn J, Stranieri, Maria T, Holahan, Marie A, Lyle, Elizabeth A, Baskin, Elizabeth P, Chen, I-Wu, Dancheck, Kimberly B, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P
Published in Journal of medicinal chemistry (13.08.1998)
Published in Journal of medicinal chemistry (13.08.1998)
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Journal Article
Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes
Rubanyi, Gabor M., Ho, Elena H., Cantor, Elinor H., Lumma, William C., Botelho, Lynne H.Parker
Published in Biochemical and biophysical research communications (31.12.1991)
Published in Biochemical and biophysical research communications (31.12.1991)
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Journal Article
Potent Noncovalent Thrombin Inhibitors That Utilize the Unique Amino Acid d-Dicyclohexylalanine in the P3 Position. Implications on Oral Bioavailability and Antithrombotic Efficacy
Tucker, Thomas J, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Lucas, Bobby J, Baskin, Elizabeth P, Woltmann, Richard, Lynch, Joseph J, Lyle, Elizabeth A, Appleby, Sandra D, Chen, I-Wu, Dancheck, Kimberley B, Vacca, Joseph P
Published in Journal of medicinal chemistry (23.05.1997)
Published in Journal of medicinal chemistry (23.05.1997)
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Journal Article
A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity
Tucker, Thomas J, Lumma, William C, Payne, Linda S, Wai, Jenny M, De Solms, S. Jane, Giuliani, Elizabeth A, Darke, Paul L, Heimbach, Jill C, Zugay, Joan A
Published in Journal of medicinal chemistry (01.07.1992)
Published in Journal of medicinal chemistry (01.07.1992)
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Journal Article
Cardiotonic agents. 1. Novel 8-aryl substituted imidazo[1,2-a]- and -[1,5-a]pyridines and imidazo[1,5-a]pyridinones as potential positive inotropic agents
Davey, David, Erhardt, Paul W, Lumma, William C, Wiggins, Jay, Sullivan, Mark, Pang, David, Cantor, Elinor
Published in Journal of medicinal chemistry (01.08.1987)
Published in Journal of medicinal chemistry (01.08.1987)
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Journal Article
Rational design of 4-[(methylsulfonyl)amino]benzamides as class III antiarrhythmic agents
Lumma, William C, Wohl, Ronald A, Davey, David D, Argentieri, Thomas M, DeVita, Robert J, Gomez, Robert P, Jain, Vijay K, Marisca, Anthony J, Morgan, Thomas K
Published in Journal of medicinal chemistry (01.05.1987)
Published in Journal of medicinal chemistry (01.05.1987)
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Journal Article
Synthesis and cardiac electrophysiological activity of N-substituted-4-(1H-imidazol-1-yl)benzamides - new selective class III agents
Morgan, Thomas K, Lis, Randall, Lumma, William C, Nickisch, Klaus, Wohl, Ronald A, Phillips, Gary B, Gomez, Robert P, Lampe, John W, Di Meo, Susan V
Published in Journal of medicinal chemistry (01.04.1990)
Published in Journal of medicinal chemistry (01.04.1990)
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Journal Article
Synthesis and pharmacological studies of N-[4-[2-hydroxy-3-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]propoxy]phenyl]methanesulfonamide, a novel antiarrhythmic agent with class II and class III activities
Morgan, Thomas K, Lis, Randall, Lumma, William C, Wohl, Ronald A, Nickisch, Klaus, Phillips, Gary B, Lind, Joan M, Lampe, John W, Di Meo, Susan V
Published in Journal of medicinal chemistry (01.04.1990)
Published in Journal of medicinal chemistry (01.04.1990)
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Journal Article
Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[.omega.-[4-[(alkylsulfonyl)amino]phenyl]-.omega.-hydroxyalkyl]-1H-imidazolium salts and related compounds
Lis, Randall, Morgan, Thomas K, DeVita, Robert J, Davey, David D, Lumma, William C, Wohl, Ronald A, Diamond, Julius, Wong, Samuel S, Sullivan, Mark E
Published in Journal of medicinal chemistry (01.04.1987)
Published in Journal of medicinal chemistry (01.04.1987)
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Journal Article
Heterocyclic analogs of benzamide antiarrhythmic agents
Hanna, Reda, Lampe, John W, Lumma, William C, Erhardt, Paul W, Wong, Samuel S, Sullivan, Mark E
Published in Journal of medicinal chemistry (01.03.1989)
Published in Journal of medicinal chemistry (01.03.1989)
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Journal Article
Martinelline and Martinellic Acid, Novel G-Protein Linked Receptor Antagonists from the Tropical Plant Martinella iquitosensis (Bignoniaceae)
Witherup, Keith M, Ransom, Richard W, Graham, Amy C, Bernard, Aurora M, Salvatore, Michael J, Lumma, William C, Anderson, Paul S, Pitzenberger, Steven M, Varga, Sandor L
Published in Journal of the American Chemical Society (01.06.1995)
Published in Journal of the American Chemical Society (01.06.1995)
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Journal Article
Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460): Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support
Brady, Stephen F, Stauffer, Kenneth J, Lumma, William C, Smith, Graham M, Ramjit, Harri G, Lewis, S. Dale, Lucas, Bobby J, Gardell, Steven J, Lyle, Elizabeth A, Appleby, Sandra D, Cook, Jacquelynn J, Holahan, Marie A, Stranieri, Maria T, Lynch, Joseph J, Lin, Jiunn H, Chen, I.-Wu, Vastag, Kari, Naylor-Olsen, Adel M, Vacca, Joseph P
Published in Journal of medicinal chemistry (29.01.1998)
Published in Journal of medicinal chemistry (29.01.1998)
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