Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates
Zhu, Xuling, Yin, Ling, Theisen, Matt, Zhuo, Jenny, Siddiqui, Summar, Levy, Becca, Presnyak, Vladimir, Frassetto, Andrea, Milton, Jaclyn, Salerno, Timothy, Benenato, Kerry E., Milano, Joe, Lynn, Andy, Sabnis, Staci, Burke, Kristine, Besin, Gilles, Lukacs, Christine M., Guey, Lin T., Finn, Patrick F., Martini, Paolo G.V.
Published in American journal of human genetics (04.04.2019)
Published in American journal of human genetics (04.04.2019)
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Journal Article
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia
Jiang, Lei, Park, Ji-Sun, Yin, Ling, Laureano, Rodrigo, Jacquinet, Eric, Yang, Jinsong, Liang, Shi, Frassetto, Andrea, Zhuo, Jenny, Yan, Xinhua, Zhu, Xuling, Fortucci, Steven, Hoar, Kara, Mihai, Cosmin, Tunkey, Christopher, Presnyak, Vlad, Benenato, Kerry E., Lukacs, Christine M., Martini, Paolo G. V., Guey, Lin T.
Published in Nature communications (21.10.2020)
Published in Nature communications (21.10.2020)
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Journal Article
Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia
An, Ding, Schneller, Jessica L., Frassetto, Andrea, Liang, Shi, Zhu, Xuling, Park, Ji-Sun, Theisen, Matt, Hong, Sue-Jean, Zhou, Jenny, Rajendran, Raj, Levy, Becca, Howell, Rebecca, Besin, Gilles, Presnyak, Vladimir, Sabnis, Staci, Murphy-Benenato, Kerry E., Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Lukacs, Christine M., Chandler, Randy J., Guey, Lin T., Venditti, Charles P., Martini, Paolo G.V.
Published in Cell reports (Cambridge) (19.12.2017)
Published in Cell reports (Cambridge) (19.12.2017)
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Journal Article
Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemia
An, Ding, Frassetto, Andrea, Jacquinet, Eric, Eybye, Marianne, Milano, Joseph, DeAntonis, Christine, Nguyen, Vi, Laureano, Rodrigo, Milton, Jaclyn, Sabnis, Staci, Lukacs, Christine M., Guey, Lin T.
Published in EBioMedicine (01.07.2019)
Published in EBioMedicine (01.07.2019)
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Journal Article
Systemic messenger RNA as an etiological treatment for acute intermittent porphyria
Jiang, Lei, Berraondo, Pedro, Jericó, Daniel, Guey, Lin T, Sampedro, Ana, Frassetto, Andrea, Benenato, Kerry E, Burke, Kristine, Santamaría, Eva, Alegre, Manuel, Pejenaute, Álvaro, Kalariya, Mayur, Butcher, William, Park, Ji-Sun, Zhu, Xuling, Sabnis, Staci, Kumarasinghe, E Sathyajith, Salerno, Timothy, Kenney, Matthew, Lukacs, Christine M, Ávila, Matías A, Martini, Paolo G V, Fontanellas, Antonio
Published in Nature medicine (01.12.2018)
Published in Nature medicine (01.12.2018)
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Journal Article
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
Rai, Ganesha, Brimacombe, Kyle R, Mott, Bryan T, Urban, Daniel J, Hu, Xin, Yang, Shyh-Ming, Lee, Tobie D, Cheff, Dorian M, Kouznetsova, Jennifer, Benavides, Gloria A, Pohida, Katie, Kuenstner, Eric J, Luci, Diane K, Lukacs, Christine M, Davies, Douglas R, Dranow, David M, Zhu, Hu, Sulikowski, Gary, Moore, William J, Stott, Gordon M, Flint, Andrew J, Hall, Matthew D, Darley-Usmar, Victor M, Neckers, Leonard M, Dang, Chi V, Waterson, Alex G, Simeonov, Anton, Jadhav, Ajit, Maloney, David J
Published in Journal of medicinal chemistry (22.11.2017)
Published in Journal of medicinal chemistry (22.11.2017)
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Journal Article
Characterization of an Acinetobacter baumannii Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate
De Vitto, Humberto, Belfon, Kafi K. J., Sharma, Nandini, Toay, Sarah, Abendroth, Jan, Dranow, David. M., Lukacs, Christine M., Choi, Ryan, Udell, Hannah S., Willis, Sydney, Barrera, George, Beyer, Olive, Li, Teng Da, Hicks, Katherine A., Torelli, Andrew T., French, Jarrod B.
Published in Biochemistry (Easton) (02.02.2024)
Published in Biochemistry (Easton) (02.02.2024)
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Journal Article
Optimization of ether and aniline based inhibitors of lactate dehydrogenase
Christov, Plamen P., Kim, Kwangho, Jana, Somnath, Romaine, Ian M., Rai, Ganesha, Mott, Bryan T., Allweil, Alexander A., Lamers, Alexander, Brimacombe, Kyle R., Urban, Daniel J., Lee, Tobie D., Hu, Xin, Lukacs, Christine M., Davies, Douglas R., Jadhav, Ajit, Hall, Matthew D., Green, Neal, Moore, William J., Stott, Gordon M., Flint, Andrew J., Maloney, David J., Sulikowski, Gary A., Waterson, Alex G.
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Journal Article
Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia
An, Ding, Schneller, Jessica L., Frassetto, Andrea, Liang, Shi, Zhu, Xuling, Park, Ji-Sun, Theisen, Matt, Hong, Sue-Jean, Zhou, Jenny, Rajendran, Raj, Levy, Becca, Howell, Rebecca, Besin, Gilles, Presnyak, Vladimir, Sabnis, Staci, Murphy-Benenato, Kerry E., Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Lukacs, Christine M., Chandler, Randy J., Guey, Lin T., Venditti, Charles P., Martini, Paolo G.V.
Published in Cell reports (Cambridge) (28.08.2018)
Published in Cell reports (Cambridge) (28.08.2018)
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Journal Article
Benzazepinones and Benzoxazepinones as Antagonists of Inhibitor of Apoptosis Proteins (IAPs) Selective for the Second Baculovirus IAP Repeat (BIR2) Domain
Donnell, Andrew F, Michoud, Christophe, Rupert, Kenneth C, Han, Xiaochun, Aguilar, Douglas, Frank, Karl B, Fretland, Adrian J, Gao, Lin, Goggin, Barry, Hogg, J. Heather, Hong, Kyoungja, Janson, Cheryl A, Kester, Robert F, Kong, Norman, Le, Kang, Li, Shirley, Liang, Weiling, Lombardo, Louis J, Lou, Yan, Lukacs, Christine M, Mischke, Steven, Moliterni, John A, Polonskaia, Ann, Schutt, Andrew D, Solis, Dave S, Specian, Anthony, Taylor, Robert T, Weisel, Martin, Remiszewski, Stacy W
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Journal Article
Optimization of Benzodiazepinones as Selective Inhibitors of the X‑Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain
Kester, Robert F, Donnell, Andrew F, Lou, Yan, Remiszewski, Stacy W, Lombardo, Louis J, Chen, Shaoqing, Le, Nam T, Lo, Jennifer, Moliterni, John A, Han, Xiaochun, Hogg, J. Heather, Liang, Weiling, Michoud, Christophe, Rupert, Kenneth C, Mischke, Steven, Le, Kang, Weisel, Martin, Janson, Cheryl A, Lukacs, Christine M, Fretland, Adrian J, Hong, Kyoungja, Polonskaia, Ann, Gao, Lin, Li, Shirley, Solis, Dave S, Aguilar, Doug, Tardell, Christine, Dvorozniak, Mark, Tannu, Shahid, Lee, Edmund C, Schutt, Andy D, Goggin, Barry
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Journal Article
Discovery of a novel series of 4-quinolone JNK inhibitors
Gong, Leyi, Tan, Yun-Chou, Boice, Genevieve, Abbot, Sarah, McCaleb, Kristen, Iyer, Pravin, Zuo, Fengrong, Porto, Joseph Dal, Wong, Brian, Jin, Sue, Chang, Alice, Tran, Patricia, Hsieh, Gary, Niu, Linghao, Shao, Ada, Reuter, Deborah, Lukacs, Christine M., Ursula Kammlott, R., Kuglstatter, Andreas, Goldstein, David
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia
Abendroth, Jan, Choi, Ryan, Wall, Abigail, Clifton, Matthew C., Lukacs, Christine M., Staker, Bart L., Van Voorhis, Wesley, Myler, Peter, Lorimer, Don D., Edwards, Thomas E.
Published in Acta crystallographica. Section F, Structural biology communications (01.05.2015)
Published in Acta crystallographica. Section F, Structural biology communications (01.05.2015)
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Journal Article
Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor
Haynes, Nancy-Ellen, Scott, Nathan R, Chen, Li C, Janson, Cheryl A, Li, Jia Kui, Lukacs, Christine M, Railkar, Aruna, Tozzo, Effie, Whittard, Toni, Brown, Nicholas F, Cheung, Adrian Wai-Hing
Published in ACS medicinal chemistry letters (13.09.2012)
Published in ACS medicinal chemistry letters (13.09.2012)
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Journal Article
The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: An intermediate conformation with T-state and R-state features
Lukacs, Christine M., Oikonomakos, Nikos G., Crowther, Robert L., Hong, Li-Na, Kammlott, R. Ursula, Levin, Wayne, Li, Shirley, Liu, Chao-Min, Lucas-McGady, Debra, Pietranico, Sherrie, Reik, Linda
Published in Proteins, structure, function, and bioinformatics (01.06.2006)
Published in Proteins, structure, function, and bioinformatics (01.06.2006)
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Journal Article
Structural Change in α-Chymotrypsin Induced by Complexation with α1-Antichymotrypsin As Seen by Enhanced Sensitivity to Proteolysis
Stavridi, Elena S, O'Malley, Kevin, Lukacs, Christine M, Moore, William T, Lambris, John D, Christianson, David W, Rubin, Harvey, Cooperman, Barry S
Published in Biochemistry (Easton) (20.08.1996)
Published in Biochemistry (Easton) (20.08.1996)
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Journal Article
Structure of free BglII reveals an unprecedented scissor-like motion for opening an endonuclease
Lukacs, C M, Kucera, R, Schildkraut, I, Aggarwal, A K
Published in Nature structural & molecular biology (01.02.2001)
Published in Nature structural & molecular biology (01.02.2001)
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Journal Article
BglII and MunI: what a difference a base makes
Lukacs, Christine M, Aggarwal, Aneel K
Published in Current Opinion in Structural Biology (01.02.2001)
Published in Current Opinion in Structural Biology (01.02.2001)
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Book Review
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