MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM
Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2019)
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Journal Article
Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysine 36
Shi, Xiaobing, Kachirskaia, Ioulia, Walter, Kay L., Kuo, Jen-Hao A., Lake, Aimee, Davrazou, Foteini, Chan, Steve M., Martin, David G.E., Fingerman, Ian M., Briggs, Scott D., Howe, LeAnn, Utz, Paul J., Kutateladze, Tatiana G., Lugovskoy, Alexey A., Bedford, Mark T., Gozani, Or
Published in The Journal of biological chemistry (26.01.2007)
Published in The Journal of biological chemistry (26.01.2007)
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Journal Article
Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle
Zhang, Kathy, Geddie, Melissa L, Kohli, Neeraj, Kornaga, Tad, Kirpotin, Dmitri B, Jiao, Yang, Rennard, Rachel, Drummond, Daryl C, Nielsen, Ulrik B, Xu, Lihui, Lugovskoy, Alexey A
Published in mAbs (01.01.2015)
Published in mAbs (01.01.2015)
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Journal Article
Conserved amino acid networks involved in antibody variable domain interactions
Wang, Norman, Smith, William F., Miller, Brian R., Aivazian, Dikran, Lugovskoy, Alexey A., Reff, Mitchell E., Glaser, Scott M., Croner, Lisa J., Demarest, Stephen J.
Published in Proteins, structure, function, and bioinformatics (01.07.2009)
Published in Proteins, structure, function, and bioinformatics (01.07.2009)
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Journal Article
A Novel Approach for Characterizing Protein Ligand Complexes: Molecular Basis for Specificity of Small-Molecule Bcl-2 Inhibitors
Lugovskoy, Alexey A, Degterev, Alexei I, Fahmy, Amr F, Zhou, Pei, Gross, John D, Yuan, Junying, Wagner, Gerhard
Published in Journal of the American Chemical Society (20.02.2002)
Published in Journal of the American Chemical Society (20.02.2002)
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Journal Article
A novel screening method to assess developability of antibody-like molecules
Kohli, Neeraj, Jain, Nidhi, Geddie, Melissa L, Razlog, Maja, Xu, Lihui, Lugovskoy, Alexey A
Published in mAbs (04.07.2015)
Published in mAbs (04.07.2015)
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Journal Article
Solution Structure of DFF40 and DFF45 N-Terminal Domain Complex and Mutual Chaperone Activity of DFF40 and DFF45
Zhou, Pei, Lugovskoy, Alexey A., McCarty, John S., Li, Peng, Wagner, Gerhard
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2001)
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Journal Article
MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors
Fitzgerald, Jonathan B, Johnson, Bryan W, Baum, Jason, Adams, Sharlene, Iadevaia, Sergio, Tang, Jian, Rimkunas, Victoria, Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Razlog, Maja, Jiao, Yang, Harms, Brian D, Olivier, Jr, Kenneth J, Schoeberl, Birgit, Nielsen, Ulrik B, Lugovskoy, Alexey A
Published in Molecular cancer therapeutics (01.02.2014)
Published in Molecular cancer therapeutics (01.02.2014)
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Journal Article
Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer
Camblin, Adam J, Pace, Emily A, Adams, Sharlene, Curley, Michael D, Rimkunas, Victoria, Nie, Lin, Tan, Gege, Bloom, Troy, Iadevaia, Sergio, Baum, Jason, Minx, Charlene, Czibere, Akos, Louis, Chrystal U, Drummond, Daryl C, Nielsen, Ulrik B, Schoeberl, Birgit, Pipas, J Marc, Straubinger, Robert M, Askoxylakis, Vasileios, Lugovskoy, Alexey A
Published in Clinical cancer research (15.06.2018)
Published in Clinical cancer research (15.06.2018)
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Journal Article
Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer
Camblin, Adam J., Tan, Gege, Curley, Michael D., Yannatos, Isabel, Iadevaia, Sergio, Rimkunas, Victoria, Mino-Kenudson, Mari, Bloom, Troy, Schoeberl, Birgit, Drummond, Daryl C., Lugovskoy, Alexey A., Louis, Chrystal U., Askoxylakis, Vasileios
Published in Scientific reports (14.11.2019)
Published in Scientific reports (14.11.2019)
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Journal Article
Small-Molecule Inhibition of TNF-α
He, Molly M., Smith, Annemarie Stroustrup, Oslob, Johan D., Flanagan, William M., Braisted, Andrew C., Whitty, Adrian, Cancilla, Mark T., Wang, Jun, Lugovskoy, Alexey A., Yoburn, Josh C., Fung, Amy D., Farrington, Graham, Eldredge, John K., Day, Eric S., Cruz, Leslie A., Cachero, Teresa G., Miller, Stephan K., Friedman, Jessica E., Choong, Ingrid C., Cunningham, Brian C.
Published in Science (American Association for the Advancement of Science) (11.11.2005)
Published in Science (American Association for the Advancement of Science) (11.11.2005)
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Journal Article
Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting
Geddie, Melissa L, Kohli, Neeraj, Kirpotin, Dmitri B, Razlog, Maja, Jiao, Yang, Kornaga, Tad, Rennard, Rachel, Xu, Lihui, Schoerberl, Birgit, Marks, James D, Drummond, Daryl C, Lugovskoy, Alexey A
Published in mAbs (01.01.2017)
Published in mAbs (01.01.2017)
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Journal Article
The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor
Gozani, Or, Karuman, Philip, Jones, David R., Ivanov, Dmitri, Cha, James, Lugovskoy, Alexey A., Baird, Cheryl L., Zhu, Hong, Field, Seth J., Lessnick, Stephen L., Villasenor, Jennifer, Mehrotra, Bharat, Chen, Jian, Rao, Vikram R., Brugge, Joan S., Ferguson, Colin G., Payrastre, Bernard, Myszka, David G., Cantley, Lewis C., Wagner, Gerhard, Divecha, Nullin, Prestwich, Glenn D., Yuan, Junying
Published in Cell (11.07.2003)
Published in Cell (11.07.2003)
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