Identification of RIP1 kinase as a specific cellular target of necrostatins
Degterev, Alexei, Yuan, Junying, Hitomi, Junichi, Germscheid, Megan, Ch'en, Irene L, Korkina, Olga, Teng, Xin, Abbott, Derek, Cuny, Gregory D, Yuan, Chengye, Wagner, Gerhard, Hedrick, Stephen M, Gerber, Scott A, Lugovskoy, Alexey
Published in Nature chemical biology (01.05.2008)
Published in Nature chemical biology (01.05.2008)
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A novel screening method to assess developability of antibody-like molecules
Kohli, Neeraj, Jain, Nidhi, Geddie, Melissa L, Razlog, Maja, Xu, Lihui, Lugovskoy, Alexey A
Published in mAbs (04.07.2015)
Published in mAbs (04.07.2015)
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Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism
Marcotte, Douglas, Zeng, Weike, Hus, Jean-Christophe, McKenzie, Andres, Hession, Cathy, Jin, Ping, Bergeron, Chris, Lugovskoy, Alexey, Enyedy, Istvan, Cuervo, Hernan, Wang, Deping, Atmanene, Cédric, Roecklin, Dominique, Vecchi, Malgorzata, Vivat, Valérie, Kraemer, Joachim, Winkler, Dirk, Hong, Victor, Chao, Jianhua, Lukashev, Matvey, Silvian, Laura
Published in Bioorganic & medicinal chemistry (15.07.2013)
Published in Bioorganic & medicinal chemistry (15.07.2013)
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Journal Article
MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM
Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2019)
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Journal Article
MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors
Fitzgerald, Jonathan B, Johnson, Bryan W, Baum, Jason, Adams, Sharlene, Iadevaia, Sergio, Tang, Jian, Rimkunas, Victoria, Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Razlog, Maja, Jiao, Yang, Harms, Brian D, Olivier, Jr, Kenneth J, Schoeberl, Birgit, Nielsen, Ulrik B, Lugovskoy, Alexey A
Published in Molecular cancer therapeutics (01.02.2014)
Published in Molecular cancer therapeutics (01.02.2014)
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Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer
Camblin, Adam J, Pace, Emily A, Adams, Sharlene, Curley, Michael D, Rimkunas, Victoria, Nie, Lin, Tan, Gege, Bloom, Troy, Iadevaia, Sergio, Baum, Jason, Minx, Charlene, Czibere, Akos, Louis, Chrystal U, Drummond, Daryl C, Nielsen, Ulrik B, Schoeberl, Birgit, Pipas, J Marc, Straubinger, Robert M, Askoxylakis, Vasileios, Lugovskoy, Alexey A
Published in Clinical cancer research (15.06.2018)
Published in Clinical cancer research (15.06.2018)
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Journal Article
Identification and Characterization of Mefloquine Efficacy against JC Virus In Vitro
BRICKELMAIER, Margot, LUGOVSKOY, Alexey, KARTIKEYAN, Ramya, REVIRIEGO-MENDOZA, Marta M, ALLAIRE, Norm, SIMON, Kenneth, FRISQUE, Richard J, GORELIK, Leonid
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
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Journal Article
Humanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma
Eavarone, David A, Al-Alem, Linah, Lugovskoy, Alexey, Prendergast, Jillian M, Nazer, Rawan I, Stein, Jenna N, Dransfield, Daniel T, Behrens, Jeff, Rueda, Bo R
Published in PloS one (27.07.2018)
Published in PloS one (27.07.2018)
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Journal Article
Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer
Camblin, Adam J., Tan, Gege, Curley, Michael D., Yannatos, Isabel, Iadevaia, Sergio, Rimkunas, Victoria, Mino-Kenudson, Mari, Bloom, Troy, Schoeberl, Birgit, Drummond, Daryl C., Lugovskoy, Alexey A., Louis, Chrystal U., Askoxylakis, Vasileios
Published in Scientific reports (14.11.2019)
Published in Scientific reports (14.11.2019)
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Journal Article
Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysine 36
Shi, Xiaobing, Kachirskaia, Ioulia, Walter, Kay L., Kuo, Jen-Hao A., Lake, Aimee, Davrazou, Foteini, Chan, Steve M., Martin, David G.E., Fingerman, Ian M., Briggs, Scott D., Howe, LeAnn, Utz, Paul J., Kutateladze, Tatiana G., Lugovskoy, Alexey A., Bedford, Mark T., Gozani, Or
Published in The Journal of biological chemistry (26.01.2007)
Published in The Journal of biological chemistry (26.01.2007)
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Journal Article
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains
Miao, Benchun, Skidan, Igor, Yang, Jinsheng, Lugovskoy, Alexey, Reibarkh, Mikhail, Long, Kai, Brazell, Tres, Durugkar, Kulbhushan A., Maki, Jenny, Ramana, C. V., Schaffhausen, Brian, Wagner, Gerhard, Torchilin, Vladimir, Yuan, Junying, Degterev, Alexei, Tsichlis, Philip N.
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2010)
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Journal Article
Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis
Pepinsky, R. Blake, Silvian, Laura, Berkowitz, Steven A., Farrington, Graham, Lugovskoy, Alexey, Walus, Lee, Eldredge, John, Capili, Allan, Mi, Sha, Graff, Christilyn, Garber, Ellen
Published in Protein science (01.05.2010)
Published in Protein science (01.05.2010)
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Journal Article
Small-Molecule Inhibition of TNF-α
He, Molly M., Smith, Annemarie Stroustrup, Oslob, Johan D., Flanagan, William M., Braisted, Andrew C., Whitty, Adrian, Cancilla, Mark T., Wang, Jun, Lugovskoy, Alexey A., Yoburn, Josh C., Fung, Amy D., Farrington, Graham, Eldredge, John K., Day, Eric S., Cruz, Leslie A., Cachero, Teresa G., Miller, Stephan K., Friedman, Jessica E., Choong, Ingrid C., Cunningham, Brian C.
Published in Science (American Association for the Advancement of Science) (11.11.2005)
Published in Science (American Association for the Advancement of Science) (11.11.2005)
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