The Endocrine Function of the Heart: Physiology and Involvements of Natriuretic Peptides and Cyclic Nucleotide Phosphodiesterases in Heart Failure
Lugnier, Claire, Meyer, Alain, Charloux, Anne, Andrès, Emmanuel, Gény, Bernard, Talha, Samy
Published in Journal of clinical medicine (21.10.2019)
Published in Journal of clinical medicine (21.10.2019)
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Design, Synthesis, and Pharmacological Evaluation of N‑Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase‑4 Inhibitors
Kümmerle, Arthur E, Schmitt, Martine, Cardozo, Suzana V. S, Lugnier, Claire, Villa, Pascal, Lopes, Alexandra B, Romeiro, Nelilma C, Justiniano, Hélène, Martins, Marco A, Fraga, Carlos A. M, Bourguignon, Jean-Jacques, Barreiro, Eliezer J
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants
Yougbare, Issaka, Belemnaba, Lazare, Morin, Caroline, Abusnina, Abdurazzag, Senouvo, Yannick F., Keravis, Thérèse, Lugnier, Claire, Rousseau, Eric
Published in Frontiers in pharmacology (18.08.2020)
Published in Frontiers in pharmacology (18.08.2020)
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Journal Article
Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells
Keravis, Thérèse, Favot, Laure, Abusnina, Abdurrazag A, Anton, Anita, Justiniano, Hélène, Soleti, Raffaella, Alabed Alibrahim, Eid, Simard, Gilles, Andriantsitohaina, Ramaroson, Lugnier, Claire
Published in PloS one (22.12.2015)
Published in PloS one (22.12.2015)
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Journal Article
Design, Synthesis, Pharmacological Evaluation and Vascular Effects of Delphinidin Analogues
Legeay, Samuel, Trân, Kien, Abatuci, Yannick, Justiniano, Hélène, Lugnier, Claire, Duval, Olivier, Helesbeux, Jean-Jacques, Faure, Sébastien
Published in Current pharmaceutical design (01.01.2018)
Published in Current pharmaceutical design (01.01.2018)
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Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor
Keravis, Thérèse, Monneaux, Fanny, Yougbaré, Issaka, Gazi, Lucien, Bourguignon, Jean-Jacques, Muller, Sylviane, Lugnier, Claire
Published in PloS one (11.01.2012)
Published in PloS one (11.01.2012)
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Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II
Mokni, Walid, Keravis, Thérèse, Etienne-Selloum, Nelly, Walter, Alison, Kane, Modou O, Schini-Kerth, Valérie B, Lugnier, Claire
Published in PloS one (03.12.2010)
Published in PloS one (03.12.2010)
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NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues
Yougbare, Issaka, Morin, Caroline, Senouvo, Farid Yannick, Sirois, Chantal, Albadine, Roula, Lugnier, Claire, Rousseau, Eric
Published in American Journal of Physiology: Cell Physiology (01.10.2011)
Published in American Journal of Physiology: Cell Physiology (01.10.2011)
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Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress
Tetsi, Liliane, Charles, Anne-Laure, Georg, Isabelle, Goupilleau, Fabienne, Lejay, Anne, Talha, Samy, Maumy-Bertrand, Myriam, Lugnier, Claire, Geny, Bernard
Published in Antioxidants (07.04.2019)
Published in Antioxidants (07.04.2019)
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VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors
Favot, Laure, Keravis, Thérèse, Holl, Vincent, Le Bec, Alain, Lugnier, Claire
Published in Thrombosis and haemostasis (01.08.2003)
Published in Thrombosis and haemostasis (01.08.2003)
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Study of the mechanisms involved in the vasorelaxation induced by (−)‐epigallocatechin‐3‐gallate in rat aorta
Álvarez, Ezequiel, Campos‐Toimil, Manuel, Justiniano‐Basaran, Hélène, Lugnier, Claire, Orallo, Francisco
Published in British journal of pharmacology (01.02.2006)
Published in British journal of pharmacology (01.02.2006)
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Journal Article
New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam
Bihel, Frédéric J.J., Justiniano, Hélène, Schmitt, Martine, Hellal, Malik, Ibrahim, Mohamed A., Lugnier, Claire, Bourguignon, Jean-Jacques
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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