Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model
Fang, Tracy-Shi Zhang, Sun, Yu, Pearce, Andrew C., Eleuteri, Simona, Kemp, Mark, Luckhurst, Christopher A., Williams, Rachel, Mills, Ross, Almond, Sarah, Burzynski, Laura, Márkus, Nóra M., Lelliott, Christopher J., Karp, Natasha A., Adams, David J., Jackson, Stephen P., Zhao, Jin-Feng, Ganley, Ian G., Thompson, Paul W., Balmus, Gabriel, Simon, David K.
Published in Nature communications (13.11.2023)
Published in Nature communications (13.11.2023)
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Journal Article
Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease
Bürli, Roland W, Luckhurst, Christopher A, Aziz, Omar, Matthews, Kim L, Yates, Dawn, Lyons, Kathy. A, Beconi, Maria, McAllister, George, Breccia, Perla, Stott, Andrew J, Penrose, Stephen D, Wall, Michael, Lamers, Marieke, Leonard, Philip, Müller, Ilka, Richardson, Christine M, Jarvis, Rebecca, Stones, Liz, Hughes, Samantha, Wishart, Grant, Haughan, Alan F, O’Connell, Catherine, Mead, Tania, McNeil, Hannah, Vann, Julie, Mangette, John, Maillard, Michel, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease
Stott, Andrew J, Maillard, Michel C, Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H, Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F, Jarvis, Rebecca E, Luckhurst, Christopher A, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poël, Amanda J, Vater, Huw D, Vann, Julie, Williams, Rachel, Yates, Dawn, Muñoz-Sanjuán, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors
Luckhurst, Christopher A, Breccia, Perla, Stott, Andrew J, Aziz, Omar, Birch, Helen L, Bürli, Roland W, Hughes, Samantha J, Jarvis, Rebecca E, Lamers, Marieke, Leonard, Philip M, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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Journal Article
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington’s Disease
Ladduwahetty, Tammy, Lee, Matthew R., Maillard, Michel C., Cachope, Roger, Todd, Daniel, Barnes, Michael, Beaumont, Vahri, Chauhan, Alka, Gallati, Caroline, Haughan, Alan F., Kempf, Georg, Luckhurst, Christopher A., Matthews, Kim, McAllister, George, Mitchell, Philip, Patel, Hiral, Rose, Mark, Saville-Stones, Elizabeth, Steinbacher, Stefan, Stott, Andrew J., Thatcher, Emma, Tierney, Jason, Urbonas, Liudvikas, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.07.2022)
Published in Journal of medicinal chemistry (28.07.2022)
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Journal Article
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor
Luckhurst, Christopher A., Aziz, Omar, Beaumont, Vahri, Bürli, Roland W., Breccia, Perla, Maillard, Michel C., Haughan, Alan F., Lamers, Marieke, Leonard, Phil, Matthews, Kim L., Raphy, Gilles, Stott, Andrew J., Munoz-Sanjuan, Ignacio, Thomas, Beth, Wall, Michael, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
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Journal Article
Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists
Luckhurst, Christopher A., Stein, Linda A., Furber, Mark, Webb, Nicola, Ratcliffe, Marianne J., Allenby, Gary, Botterell, Sara, Tomlinson, Wendy, Martin, Barrie, Walding, Andrew
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
Bahl, Ash, Barton, Patrick, Bowers, Keith, Caffrey, Moya V., Denton, Rebecca, Gilmour, Peter, Hawley, Shaun, Linannen, Tero, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W.D., Riley, Robert J., Roe, Emma, Springthorpe, Brian, Stein, Linda, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article
Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists
Luckhurst, Christopher A., Ratcliffe, Marianne, Stein, Linda, Furber, Mark, Botterell, Sara, Laughton, David, Tomlinson, Wendy, Weaver, Richard, Chohan, Kamaldeep, Walding, Andrew
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
The discovery of CCR3/H1 dual antagonists with reduced hERG risk
Bahl, Ash, Barton, Patrick, Bowers, Keith, Brough, Steven, Evans, Richard, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W.D., Rigby, Aaron, Riley, Robert J., Sanganee, Hitesh, Sisson, Adam, Springthorpe, Brian
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article
히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법
WISHART GRANT, DOMINGUEZ CELIA, MAILLARD MICHEL C, JARVIS REBECCA E, BRECCIA PERLA, SAVILLE STONES ELIZABETH A, VAN DE POEL AMANDA, HAUGHAN ALAN F, LUCKHURST CHRISTOPHER A, WALL MICHAEL, STOTT ANDREW J
Year of Publication 08.01.2018
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Year of Publication 08.01.2018
Patent
히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법
WISHART GRANT, DOMINGUEZ CELIA, MAILLARD MICHEL C, JARVIS REBECCA E, VAN DE POEL AMANDA, SAVILLE STONES ELIZABETH A, BRECCIA PERLA, HAUGHAN ALAN F, LUCKHURST CHRISTOPHER A, WALL MICHAEL, STOTT ANDREW J
Year of Publication 08.01.2018
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Year of Publication 08.01.2018
Patent
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class Ha histone deacetylase inhibitor
Luckhurst, Christopher A., Aziz, Omar, Beaumont, Vahri, Burli, Roland W., Breccia, Perla, Maillard, Michel C., Haughan, Alan F., Lamers, Marieke, Leonard, Phil, Matthews, Kim L., Raphy, Gilles, Stott, Andrew J., Munoz-Sanjuan, Ignacio, Thomas, Beth, Wall, Michael, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
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Journal Article
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class Ila HDAC Inhibitors for Huntington's Disease
Stott, Andrew J., Maillard, Michel C., Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H., Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F., Jarvis, Rebecca E., Luckhurst, Christopher A., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poel, Amanda J., Vater, Huw D., Vann, Julie, Williams, Rachel, Yates, Dawn, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
WISHART GRANT, PENROSE STEPHEN D, SAVILLE STONES ELIZABETH, JARVIS REBECCA E, RAPHY GILLES, MUNOZ SANJUAN IGNACIO, LUCKHURST CHRISTOPHER A, HAUGHAN ALAN F, ALLEN DANIEL R, BURLI ROLAND W, DOMINGUEZ CELIA, BRECCIA PERLA, WALL MICHAEL, HUGHES SAMANTHA J, VATER HUW D, STOTT ANDREW J
Year of Publication 02.02.2017
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Year of Publication 02.02.2017
Patent
Abstract 454: Validation of GPR35 as a novel cancer target in digestive tract cancers and discovery of potent, selective GPR35 inverse agonists
Westcott, James, Luckhurst, Christopher A., McKenzie, Grahame, Memon, Danish, Lin, Li-Chiung, Knight, Sinead, Blaikley, Elizabeth J., Pearce, Martin, Warren, Hannah R., Parker, Eleanor, Milligan, Graeme, Hughes, Stuart W., McCarthy, Tom
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class Ila Histone Deacetylase (HDAC) Inhibitors
Luckhurst, Christopher A., Breccia, Perla, Stott, Andrew J., Aziz, Omar, Birch, Helen L., Buerli, Roland W., Hughes, Samantha J., Jarvis, Rebecca E., Lamers, Marieke, Leonard, Philip M., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in ACS medicinal chemistry letters (01.01.2016)
Published in ACS medicinal chemistry letters (01.01.2016)
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Journal Article
The discovery of CCR3/H-1 dual antagonists with reduced hERG risk
Bahl, Ash, Barton, Patrick, Bowers, Keith, Brough, Steven, Evans, Richard, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W. D., Rigby, Aaron, Riley, Robert J., Sanganee, Hitesh, Sisson, Adam, Springthorpe, Brian
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article