Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors
Lucas, Simon C. C, Atkinson, Stephen J, Chung, Chun-wa, Davis, Rob, Gordon, Laurie, Grandi, Paola, Gray, James J. R, Grimes, Thomas, Phillipou, Alexander, Preston, Alex G, Prinjha, Rab K, Rioja, Inmaculada, Taylor, Simon, Tomkinson, Nicholas C. O, Wall, Ian, Watson, Robert J, Woolven, James, Demont, Emmanuel H
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
Towards a comprehensive sustainability methodology to assess anthropogenic impacts on ecosystems: Review of the integration of Life Cycle Assessment, Environmental Risk Assessment and Ecosystem Services Assessment
De Luca Peña, Laura Vittoria, Taelman, Sue Ellen, Préat, Nils, Boone, Lieselot, Van der Biest, Katrien, Custódio, Marco, Hernandez Lucas, Simon, Everaert, Gert, Dewulf, Jo
Published in The Science of the total environment (20.02.2022)
Published in The Science of the total environment (20.02.2022)
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Journal Article
Synthesis of Benzothiazinones from Benzoyl Thiocarbamates: Application to Clinical Candidates for Tuberculosis Treatment
Connors, William, DeKorte, Ryan, Lucas, Simon C. C., Gopalsamy, Ariamala, Ziegler, Robert E.
Published in European journal of organic chemistry (13.09.2022)
Published in European journal of organic chemistry (13.09.2022)
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Journal Article
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode
Lucas, Simon C. C, Atkinson, Stephen J, Bamborough, Paul, Barnett, Heather, Chung, Chun-wa, Gordon, Laurie, Mitchell, Darren J, Phillipou, Alexander, Prinjha, Rab K, Sheppard, Robert J, Tomkinson, Nicholas C. O, Watson, Robert J, Demont, Emmanuel H
Published in Journal of medicinal chemistry (28.05.2020)
Published in Journal of medicinal chemistry (28.05.2020)
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Journal Article
Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines
Alamillo-Ferrer, Carla, Curle, Jonathan M, Davidson, Stuart C, Lucas, Simon C. C, Atkinson, Stephen J, Campbell, Matthew, Kennedy, Alan R, Tomkinson, Nicholas C. O
Published in Journal of organic chemistry (15.06.2018)
Published in Journal of organic chemistry (15.06.2018)
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Journal Article
Hit me with your best shot: Integrated hit discovery for the next generation of drug targets
Ashraf, S. Neha, Blackwell, J. Henry, Holdgate, Geoffrey A., Lucas, Simon C.C., Solovyeva, Alisa, Storer, R. Ian, Whitehurst, Benjamin C.
Published in Drug discovery today (01.10.2024)
Published in Drug discovery today (01.10.2024)
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Journal Article
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification
Bamborough, Paul, Chung, Chun-wa, Demont, Emmanuel H, Bridges, Angela M, Craggs, Peter D, Dixon, David P, Francis, Peter, Furze, Rebecca C, Grandi, Paola, Jones, Emma J, Karamshi, Bhumika, Locke, Kelly, Lucas, Simon C. C, Michon, Anne-Marie, Mitchell, Darren J, Pogány, Peter, Prinjha, Rab K, Rau, Christina, Roa, Ana Maria, Roberts, Andrew D, Sheppard, Robert J, Watson, Robert J
Published in Journal of medicinal chemistry (22.08.2019)
Published in Journal of medicinal chemistry (22.08.2019)
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Journal Article
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders
Lucas, Simon C. C., Ahmed, Afshan, Ashraf, S. Neha, Argyrou, Argyrides, Bauer, Matthias R., De Donatis, Gian Marco, Demanze, Sylvain, Eisele, Frederik, Fusani, Lucia, Hock, Andreas, Kadamur, Ganesh, Li, Shuyou, Macmillan-Jones, Abigail, Michaelides, Iacovos N., Phillips, Christopher, Rehnström, Marie, Richter, Magdalena, Rodrigo-Brenni, Monica C., Shilliday, Fiona, Wang, Peng, Storer, R. Ian
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
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Journal Article
Mangrove sediment organic carbon storage and sources in relation to forest age and position along a deltaic salinity gradient
Suello, Rey Harvey, Hernandez, Simon Lucas, Bouillon, Steven, Belliard, Jean-Philippe, Dominguez-Granda, Luis, Van de Broek, Marijn, Rosado Moncayo, Andrea Mishell, Ramos Veliz, John, Ramirez, Karem Pollette, Govers, Gerard, Temmerman, Stijn
Published in Biogeosciences (18.03.2022)
Published in Biogeosciences (18.03.2022)
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Journal Article
Fragment screening at AstraZeneca: developing the next generation biophysics fragment set
Lucas, Simon C. C, Börjesson, Ulf, Bostock, Mark J, Cuff, John, Edfeldt, Fredrik, Embrey, Kevin J, Eriksson, Per-Olof, Gohlke, Andrea, Gunnarson, Anders, Lainchbury, Michael, Milbradt, Alexander G, Moore, Rachel, Rawlins, Philip B, Sinclair, Ian, Stubbs, Christopher, Storer, R. Ian
Published in MedChemComm (21.09.2022)
Published in MedChemComm (21.09.2022)
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Journal Article
The 2014 General Video Game Playing Competition
Perez-Liebana, Diego, Samothrakis, Spyridon, Togelius, Julian, Schaul, Tom, Lucas, Simon M., Couetoux, Adrien, Lee, Jerry, Chong-U Lim, Thompson, Tommy
Published in IEEE transactions on computational intelligence and AI in games. (01.09.2016)
Published in IEEE transactions on computational intelligence and AI in games. (01.09.2016)
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Journal Article
Prioritizing ecosystem services for marine management through stakeholder engagement
Custodio, Marco, Moulaert, Ine, Asselman, Jana, van der Biest, Katrien, van de Pol, Lennert, Drouillon, Magriet, Hernandez Lucas, Simon, Taelman, Sue Ellen, Everaert, Gert
Published in Ocean & coastal management (15.06.2022)
Published in Ocean & coastal management (15.06.2022)
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Journal Article
A high-density linkage map and sex-linked markers for the Amazon Tambaqui Colossoma macropomum
Varela, Eduardo Sousa, Bekaert, Michaël, Ganeco-Kirschnik, Luciana Nakaghi, Torati, Lucas Simon, Shiotsuki, Luciana, de Almeida, Fernanda Loureiro, Villela, Luciana Cristine Vasques, Rezende, Fabrício Pereira, da Silva Barroso, Aurisan, de Freitas, Luiz Eduardo Lima, Taggart, John Bernard, Migaud, Herve
Published in BMC genomics (02.10.2021)
Published in BMC genomics (02.10.2021)
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Journal Article
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates
Jones, S. Paul, Firth, James D, Wheldon, Mary C, Atobe, Masakazu, Hubbard, Roderick E, Blakemore, David C, De Fusco, Claudia, Lucas, Simon C. C, Roughley, Stephen D, Vidler, Lewis R, Whatton, Maria Ann, Woolford, Alison J.-A, Wrigley, Gail L, O'Brien, Peter
Published in MedChemComm (14.12.2022)
Published in MedChemComm (14.12.2022)
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Journal Article
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6
Kerres, Nina, Steurer, Steffen, Schlager, Stefanie, Bader, Gerd, Berger, Helmut, Caligiuri, Maureen, Dank, Christian, Engen, John R., Ettmayer, Peter, Fischerauer, Bernhard, Flotzinger, Gerlinde, Gerlach, Daniel, Gerstberger, Thomas, Gmaschitz, Teresa, Greb, Peter, Han, Bingsong, Heyes, Elizabeth, Iacob, Roxana E., Kessler, Dirk, Kölle, Heike, Lamarre, Lyne, Lancia, David R., Lucas, Simon, Mayer, Moriz, Mayr, Katharina, Mischerikow, Nikolai, Mück, Katja, Peinsipp, Christoph, Petermann, Oliver, Reiser, Ulrich, Rudolph, Dorothea, Rumpel, Klaus, Salomon, Carina, Scharn, Dirk, Schnitzer, Renate, Schrenk, Andreas, Schweifer, Norbert, Thompson, Diane, Traxler, Elisabeth, Varecka, Roland, Voss, Tilman, Weiss-Puxbaum, Alexander, Winkler, Sandra, Zheng, Xiaozhang, Zoephel, Andreas, Kraut, Norbert, McConnell, Darryl, Pearson, Mark, Koegl, Manfred
Published in Cell reports (Cambridge) (19.09.2017)
Published in Cell reports (Cambridge) (19.09.2017)
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